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MedKoo Cat#: 558338 | Name: Tocopherol nicotinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tocopherol nicotinate is an antioxidant used for skin conditioning.

Chemical Structure

Tocopherol nicotinate
CAS#43119-47-7

Theoretical Analysis

MedKoo Cat#: 558338

Name: Tocopherol nicotinate

CAS#: 43119-47-7

Chemical Formula: C35H53NO3

Exact Mass: 535.4000

Molecular Weight: 535.81

Elemental Analysis: C, 78.46; H, 9.97; N, 2.61; O, 8.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tocopherol nicotinate; Vitamin E nicotinate; Vitamin E nicotinic acid ester; Tocopheryl nicotinate;
IUPAC/Chemical Name
(2R-(2R*(4R*,8R*)))-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate
InChi Key
MSCCTZZBYHQMQJ-AZAGJHQNSA-N
InChi Code
InChI=1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1
SMILES Code
O=C(OC1=C(C)C(C)=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C1C)C3=CN=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 535.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chernomorets NN, Kotlubeĭ GV, Vatutin NT, Zhivotovskaia IA, Gnilitskaia VB, Alifanova RE, Lobach EIa, Mal'tseva NV, Mitrofanov AN. [The effect of tocopherol and nicotinic acid on the microcirculation and blood coagulability in patients with ischemic heart disease]. Vrach Delo. 1990 Dec;(12):6-8. Russian. PubMed PMID: 2089804. 2: Zondlo Fiume M. Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. Int J Toxicol. 2002;21 Suppl 3:51-116. Review. PubMed PMID: 12537931. 3: Zia-Ul-Haq M, Ahmad S, Bukhari SA, Amarowicz R, Ercisli S, Jaafar HZ. Compositional studies and biological activities of some mash bean (Vigna mungo (L.) Hepper) cultivars commonly consumed in Pakistan. Biol Res. 2014 May 30;47:23. doi: 10.1186/0717-6287-47-23. PubMed PMID: 25028256; PubMed Central PMCID: PMC4101733. 4: Wong YF, Makahleh A, Saad B, Ibrahim MN, Rahim AA, Brosse N. UPLC method for the determination of vitamin E homologues and derivatives in vegetable oils, margarines and supplement capsules using pentafluorophenyl column. Talanta. 2014 Dec;130:299-306. doi: 10.1016/j.talanta.2014.07.021. Epub 2014 Jul 15. PubMed PMID: 25159413. 5: Neunert G, Szwengiel A, Walejko P, Witkowski S, Polewski K. Photostability of alpha-tocopherol ester derivatives in solutions and liposomes. Spectroscopic and LC-MS studies. J Photochem Photobiol B. 2016 Jul;160:121-7. doi: 10.1016/j.jphotobiol.2016.03.032. Epub 2016 Apr 2. PubMed PMID: 27107331. 6: Schlieper P, Tawfik H. Antiarrhythmic activity of alpha-tocopherol nicotinate and related compounds and their physico-chemical properties. Arzneimittelforschung. 1987 Aug;37(8):920-3. PubMed PMID: 3675687. 7: Suzuki N, Nakamura T. Metabolism of the nicotinic acid moiety of d,l-alpha-tocopheryl nicotinate. J Nutr Sci Vitaminol (Tokyo). 1983 Apr;29(2):93-103. PubMed PMID: 6886843. 8: Koyama T, Araiso T. Effects of alpha-tocopherol-nicotinate administration on the microdynamics of phospholipids of erythrocyte membranes in human subjects. J Nutr Sci Vitaminol (Tokyo). 1988 Oct;34(5):449-57. PubMed PMID: 3230416. 9: Piacham T, Nantasenamat C, Isarankura-Na-Ayudhya C, Prachayasittikul V. Synthesis and computational investigation of molecularly imprinted nanospheres for selective recognition of alpha-tocopherol succinate. EXCLI J. 2013 Aug 14;12:701-18. eCollection 2013. PubMed PMID: 26622214; PubMed Central PMCID: PMC4662183. 10: Kakimura M. Comparative studies of the effects of alpha-tocopheryl nicotinate and the combination alpha-tocopheryl acetate and nicotinic acid. J Nutr Sci Vitaminol (Tokyo). 1973 Oct;19(5):375-81. PubMed PMID: 4792209. 11: Duncan KR, Suzuki YJ. Vitamin E Nicotinate. Antioxidants (Basel). 2017 Mar 13;6(1). pii: E20. doi: 10.3390/antiox6010020. Review. Erratum in: Antioxidants (Basel). 2018 May 03;7(5):. PubMed PMID: 28335380; PubMed Central PMCID: PMC5384183. 12: Svensson J, Oki T. Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters. Int J Vitam Nutr Res. 1978;48(3):250-4. PubMed PMID: 711383. 13: Odetti P, Cheli V, Carta G, Maiello M, Viviani GL. Effect of nicotinic acid associated with retinol and tocopherols on plasma lipids in hyperlipoproteinaemic patients. Pharmatherapeutica. 1984;4(1):21-4. PubMed PMID: 6390462. 14: Hata Y, Terashi A, Matsuzaki T, Ohtomo E, Goto Y. A prevention trial on cerebral infarction with dl-alpha-tocopheryl nicotinate--rationales for trial. The Alpha-Tocopheryl Nicotinate Prevention Study Group. J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:204-7. PubMed PMID: 1297741. 15: Baruffini A, De Lorenzi E, Gandini C, Kitsos M, Massolini G. High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations. J Chromatogr. 1992 Feb 28;593(1-2):95-7. PubMed PMID: 1639917. 16: Noma A, Maeda S, Okuno M, Abe A, Muto Y. Reduction of serum lipoprotein(a) levels in hyperlipidaemic patients with alpha-tocopheryl nicotinate. Atherosclerosis. 1990 Oct;84(2-3):213-7. PubMed PMID: 2149270. 17: Hidiroglou N, Wolynetz MS, McDowell LR, Papas AM, Antapli M, Wilkinson NS. Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol. Reprod Nutr Dev. 1993;33(3):263-8. PubMed PMID: 8216754. 18: Matoba T, Kusumoto H, Mizuki Y, Yamada K. Comparative double-blind trial of dl-alpha-tocopheryl nicotinate on vibration disease. Tohoku J Exp Med. 1977 Sep;123(1):67-75. PubMed PMID: 335571. 19: Chung TW, Yu JJ, Liu DZ. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5. PubMed PMID: 9609359. 20: Kamimura M. Comparison of alpha-tocopheryl nicotinate and acetate on skin microcirculation. Am J Clin Nutr. 1974 Oct;27(10):1110-6. PubMed PMID: 4417850.

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TNK-6123

TNK-6123