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MedKoo Cat#: 597427 | Name: BCH 2763

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BCH 2763 is a potent, selective bifunctional thrombin inhibitor that blocks both the active catalytic site and the anion binding exosite.

Chemical Structure

BCH 2763
BCH 2763
CAS#204641-27-0

Theoretical Analysis

MedKoo Cat#: 597427

Name: BCH 2763

CAS#: 204641-27-0

Chemical Formula: C64H93N11O16

Exact Mass: 1271.6802

Molecular Weight: 1272.50

Elemental Analysis: C, 60.41; H, 7.37; N, 12.11; O, 20.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
BCH 2763; BCH-2763; BCH2763;
IUPAC/Chemical Name
(S)-5-((S)-2-(((2S,3S)-1-((S)-2-((5-((S)-1-(D-phenylalanyl)pyrrolidine-2-carboxamido)pentanoyl)((S)-1-carboxy-3-methylbutyl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-((S)-2-((S)-2-(5-aminopentanamido)-3-carboxypropanamido)-3-phenylpropanamido)-5-oxopentanoic acid
InChi Key
VKIPOMGKUAJAEY-GEPLSBMPSA-N
InChi Code
InChI=1S/C64H93N11O16/c1-5-40(4)55(71-59(85)48-24-17-33-73(48)61(87)44(28-29-53(78)79)69-56(82)45(37-42-21-10-7-11-22-42)70-57(83)46(38-54(80)81)68-51(76)26-12-14-30-65)63(89)74-34-18-25-49(74)62(88)75(50(64(90)91)35-39(2)3)52(77)27-13-15-31-67-58(84)47-23-16-32-72(47)60(86)43(66)36-41-19-8-6-9-20-41/h6-11,19-22,39-40,43-50,55H,5,12-18,23-38,65-66H2,1-4H3,(H,67,84)(H,68,76)(H,69,82)(H,70,83)(H,71,85)(H,78,79)(H,80,81)(H,90,91)/t40-,43+,44-,45-,46-,47-,48-,49-,50-,55-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)N(C(CCCCNC([C@H]1N(C([C@@H](CC2=CC=CC=C2)N)=O)CCC1)=O)=O)C([C@H]3N(C([C@H]([C@@H](C)CC)NC([C@H]4N(C([C@H](CCC(O)=O)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(O)=O)NC(CCCCN)=O)=O)=O)=O)CCC4)=O)=O)CCC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,272.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McClanahan TB, Ignasiak DP, Juneau P, Finkle C, Winocour PD, Gallagher KP. Antithrombotic effects of BCH 2763, a new direct thrombin inhibitor, in a canine model of venous thrombosis. J Thromb Thrombolysis. 1999 Jun;7(3):301-6. PubMed PMID: 10375391. 2: Finkle CD, St Pierre A, Leblond L, Deschenes I, DiMaio J, Winocour PD. BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban. Thromb Haemost. 1998 Feb;79(2):431-8. PubMed PMID: 9493603. 3: Deschênes I, Finkle CD, Winocour PD. Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model. Thromb Haemost. 1998 Jul;80(1):186-91. PubMed PMID: 9684808.