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MedKoo Cat#: 591941 | Name: Di-n-octyl phthalate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Di-n-octyl phthalate (DNOP) is a chemical compound primarily used as a plasticizer, which helps make plastics more flexible and durable. It is often found in products like vinyl flooring, coatings, adhesives, and electrical cables. DNOP is a type of phthalate ester, derived from phthalic acid and octanol.

Chemical Structure

Di-n-octyl phthalate
CAS#117-84-0

Theoretical Analysis

MedKoo Cat#: 591941

Name: Di-n-octyl phthalate

CAS#: 117-84-0

Chemical Formula: C24H38O4

Exact Mass: 390.2770

Molecular Weight: 390.56

Elemental Analysis: C, 73.81; H, 9.81; O, 16.39

Price and Availability

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25mL USD 350.00 2 Weeks
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Synonym
Di-n-octyl phthalate; DNOP; Dioctyl phthalate; Vinycizer 85; NSC 15318; NSC15318; NSC-15318
IUPAC/Chemical Name
1,2-Benzenedicarboxylic acid, 1,2-dioctyl ester
InChi Key
MQIUGAXCHLFZKX-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H38O4/c1-3-5-7-9-11-15-19-27-23(25)21-17-13-14-18-22(21)24(26)28-20-16-12-10-8-6-4-2/h13-14,17-18H,3-12,15-16,19-20H2,1-2H3
SMILES Code
O=C(C1=CC=CC=C1C(OCCCCCCCC)=O)OCCCCCCCC
Appearance
Liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Di-n-octyl phthalate is a plasticizer.
In vitro activity:
ECTFE membranes are successfully prepared by thermally induced phase separation methods using DnOP (di-n-octyl phthalate) as the diluent. The theoretical calculation of the solubility parameters indicates that the ECTFE and DnOP have good compatibility. The phase diagram of the ECTFE/DnOP binary system proves the existence of one liquid–liquid phase separation zone within the prepared polymer concentration range where a final bi-continuous structure can be obtained. Reference: Membranes (Basel). 2022 Jan 1;12(1):65. https://pubmed.ncbi.nlm.nih.gov/35054591/
In vivo activity:
This study observed a low sperm count in the epididymal cross-section of 100 and 1000 mg/kg rat groups, respectively, indicating that DNOP (di-n-octyl phthalate) inhibits spermatogenesis. Reference: Ecotoxicol Environ Saf. 2021 Jan 15;208:111432. https://pubmed.ncbi.nlm.nih.gov/33075588/

Preparing Stock Solutions

The following data is based on the product molecular weight 390.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Pan J, Chen K, Cui Z, Bamaga O, Albeirutty M, Alsaiari AO, Macedonio F, Drioli E. Preparation of ECTFE Porous Membrane for Dehumidification of Gaseous Streams through Membrane Condenser. Membranes (Basel). 2022 Jan 1;12(1):65. doi: 10.3390/membranes12010065. PMID: 35054591; PMCID: PMC8781967. 2. Wolecki D, Trella B, Qi F, Stepnowski P, Kumirska J. Evaluation of the Removal of Selected Phthalic Acid Esters (PAEs) in Municipal Wastewater Treatment Plants Supported by Constructed Wetlands. Molecules. 2021 Nov 18;26(22):6966. doi: 10.3390/molecules26226966. PMID: 34834057; PMCID: PMC8621385. 3. Zhu X, Hu M, Ji H, Huang T, Ge RS, Wang Y. Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats. Ecotoxicol Environ Saf. 2021 Jan 15;208:111432. doi: 10.1016/j.ecoenv.2020.111432. Epub 2020 Oct 16. PMID: 33075588. 4. Song P, Gao J, Li X, Zhang C, Zhu L, Wang J, Wang J. Phthalate induced oxidative stress and DNA damage in earthworms (Eisenia fetida). Environ Int. 2019 Aug;129:10-17. doi: 10.1016/j.envint.2019.04.074. Epub 2019 May 15. PMID: 31102950.
In vitro protocol:
1. Pan J, Chen K, Cui Z, Bamaga O, Albeirutty M, Alsaiari AO, Macedonio F, Drioli E. Preparation of ECTFE Porous Membrane for Dehumidification of Gaseous Streams through Membrane Condenser. Membranes (Basel). 2022 Jan 1;12(1):65. doi: 10.3390/membranes12010065. PMID: 35054591; PMCID: PMC8781967. 2. Wolecki D, Trella B, Qi F, Stepnowski P, Kumirska J. Evaluation of the Removal of Selected Phthalic Acid Esters (PAEs) in Municipal Wastewater Treatment Plants Supported by Constructed Wetlands. Molecules. 2021 Nov 18;26(22):6966. doi: 10.3390/molecules26226966. PMID: 34834057; PMCID: PMC8621385.
In vivo protocol:
1. Zhu X, Hu M, Ji H, Huang T, Ge RS, Wang Y. Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats. Ecotoxicol Environ Saf. 2021 Jan 15;208:111432. doi: 10.1016/j.ecoenv.2020.111432. Epub 2020 Oct 16. PMID: 33075588. 2. Song P, Gao J, Li X, Zhang C, Zhu L, Wang J, Wang J. Phthalate induced oxidative stress and DNA damage in earthworms (Eisenia fetida). Environ Int. 2019 Aug;129:10-17. doi: 10.1016/j.envint.2019.04.074. Epub 2019 May 15. PMID: 31102950.
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