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MedKoo Cat#: 555275 | Name: MMV024101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMV024101 is a PI4K inhibitor. MMV024101 showed submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incubation.

Chemical Structure

MMV024101
CAS#1092565-44-0

Theoretical Analysis

MedKoo Cat#: 555275

Name: MMV024101

CAS#: 1092565-44-0

Chemical Formula: C16H12N6O2S

Exact Mass: 352.0742

Molecular Weight: 352.37

Elemental Analysis: C, 54.54; H, 3.43; N, 23.85; O, 9.08; S, 9.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MMV024101; MMV-024101; MMV 024101; TCMDC-134293; TCMDC134293; TCMDC 134293.
IUPAC/Chemical Name
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
InChi Key
GTWOKQIGBJADIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12N6O2S/c17-25(23,24)12-5-10(6-18-9-12)14-1-2-15-16(22-14)13(3-4-19-15)11-7-20-21-8-11/h1-9H,(H,20,21)(H2,17,23,24)
SMILES Code
O=S(C1=CC(C2=NC3=C(C4=CNN=C4)C=CN=C3C=C2)=CN=C1)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria Nishanth Kandepedu†, Diego Gonzàlez Cabrera†, Srinivas Eedubilli†, Dale Taylor‡, Christel Brunschwig‡, Liezl Gibhard‡, Mathew Njoroge‡, Nina Lawrence‡, Tanya Paquet†, Charles J. Eyermann†, Thomas Spangenberg§ , Gregory S. Basarab†, Leslie J. Street†, and Kelly Chibale*†∥