L-Lactate ion | CAS#72-08-2 | bioactive chemical

MedKoo Cat#: 597405 | Name: L-Lactate ion

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Lactate ion is the conjugate base of lactic acid.

Chemical Structure

L-Lactate ion

CAS#72-08-2

Theoretical Analysis

MedKoo Cat#: 597405

Name: L-Lactate ion

CAS#: 72-08-2

Chemical Formula: C3H5O3

Exact Mass: 89.0244

Molecular Weight: 89.07

Elemental Analysis: C, 40.45; H, 5.66; O, 53.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lactate ion, L-; L-Lactate ion; Lactate, (S)-; L-Lactate;

IUPAC/Chemical Name

2-hydroxypropanoate

InChi Key

JVTAAEKCZFNVCJ-UHFFFAOYSA-M

InChi Code

InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1

SMILES Code

OC(C)C([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 89.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zelenka J, Dvořák A, Alán L. L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis. Oxid Med Cell Longev. 2015;2015:351698. doi: 10.1155/2015/351698. Epub 2015 Jun 10. PubMed PMID: 26171114; PubMed Central PMCID: PMC4478408. 2: Gao C, Wang Y, Zhang Y, Lv M, Dou P, Xu P, Ma C. NAD-Independent L-Lactate Dehydrogenase Required for L-Lactate Utilization in Pseudomonas stutzeri A1501. J Bacteriol. 2015 Jul;197(13):2239-47. doi: 10.1128/JB.00017-15. Epub 2015 Apr 27. PubMed PMID: 25917905; PubMed Central PMCID: PMC4455268. 3: Mayeur C, Gratadoux JJ, Bridonneau C, Chegdani F, Larroque B, Kapel N, Corcos O, Thomas M, Joly F. Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome. PLoS One. 2013;8(1):e54335. doi: 10.1371/journal.pone.0054335. Epub 2013 Jan 23. PubMed PMID: 23372709; PubMed Central PMCID: PMC3553129. 4: Azzouzi S, Rotariu L, Benito AM, Maser WK, Ben Ali M, Bala C. A novel amperometric biosensor based on gold nanoparticles anchored on reduced graphene oxide for sensitive detection of l-lactate tumor biomarker. Biosens Bioelectron. 2015 Jul 15;69:280-6. doi: 10.1016/j.bios.2015.03.012. Epub 2015 Mar 7. PubMed PMID: 25771300. 5: Wei JJ, Zhang N, Wang YL, Liu QY. Poly[tetra-μ2-L-lactato-indium(III)sodium(I)]. Acta Crystallogr C. 2011 May;67(Pt 5):m145-8. doi: 10.1107/S0108270111013606. Epub 2011 Apr 15. PubMed PMID: 21540531. 6: Kan SC, Chang WF, Lan MC, Lin CC, Lai WS, Shieh CJ, Hsiung KP, Liu YC. Development of an enzymatic chromatography strip with nicotinamide adenine dinucleotide-tetrazolium coupling reactions for quantitative l-lactate analysis. Anal Biochem. 2015 Feb 15;471:61-6. doi: 10.1016/j.ab.2014.11.015. Epub 2014 Nov 29. PubMed PMID: 25454507. 7: Nielsen C, Pedersen LT, Lindholt JS, Mortensen FV, Erlandsen EJ. An automated plasma D-lactate assay with a new sample preparation method to prevent interference from L-lactate and L-lactate dehydrogenase. Scand J Clin Lab Invest. 2011 Oct;71(6):507-14. doi: 10.3109/00365513.2011.590900. Epub 2011 Aug 23. PubMed PMID: 21861600. 8: Banerjee A, Ghatak S, Sikdar SK. l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro. J Neurochem. 2016 Jul;138(2):265-81. doi: 10.1111/jnc.13638. Epub 2016 May 26. PubMed PMID: 27062641. 9: Jiang T, Xu Y, Sun X, Zheng Z, Ouyang J. Kinetic characterization of recombinant Bacillus coagulans FDP-activated l-lactate dehydrogenase expressed in Escherichia coli and its substrate specificity. Protein Expr Purif. 2014 Mar;95:219-25. doi: 10.1016/j.pep.2013.12.014. Epub 2014 Jan 8. PubMed PMID: 24412354. 10: Sun L, Li Y, Wang L, Wang Y, Yu B. Diammonium phosphate stimulates transcription of L-lactate dehydrogenase leading to increased L-lactate production in the thermotolerant Bacillus coagulans strain. Appl Microbiol Biotechnol. 2016 Aug;100(15):6653-6660. doi: 10.1007/s00253-016-7379-x. Epub 2016 Feb 17. PubMed PMID: 26883345. 11: Świderek K, Paneth P. Binding ligands and cofactor to L-lactate dehydrogenase from human skeletal and heart muscles. J Phys Chem B. 2011 May 19;115(19):6366-76. doi: 10.1021/jp201626k. Epub 2011 Apr 28. PubMed PMID: 21526780. 12: Hu AL, Liu YH, Deng HH, Hong GL, Liu AL, Lin XH, Xia XH, Chen W. Fluorescent hydrogen peroxide sensor based on cupric oxide nanoparticles and its application for glucose and L-lactate detection. Biosens Bioelectron. 2014 Nov 15;61:374-8. doi: 10.1016/j.bios.2014.05.048. Epub 2014 May 27. PubMed PMID: 24912038. 13: de Bari L, Valenti D, Atlante A, Passarella S. L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space. FEBS Lett. 2010 Jun 3;584(11):2285-90. doi: 10.1016/j.febslet.2010.03.038. Epub 2010 Mar 27. PubMed PMID: 20350544. 14: Shimomura T, Sumiya T, Ono M, Ito T, Hanaoka TA. Amperometric L-lactate biosensor based on screen-printed carbon electrode containing cobalt phthalocyanine, coated with lactate oxidase-mesoporous silica conjugate layer. Anal Chim Acta. 2012 Feb 10;714:114-20. doi: 10.1016/j.aca.2011.11.053. Epub 2011 Dec 14. PubMed PMID: 22244144. 15: Sharma S, Jain S, Nair GN, Ramachandran S. Capsicum annuum enhances L-lactate production by Lactobacillus acidophilus: implication in curd formation. J Dairy Sci. 2013 Jul;96(7):4142-8. doi: 10.3168/jds.2012-6243. Epub 2013 May 6. PubMed PMID: 23660136. 16: Pérez S, Fàbregas E. Amperometric bienzymatic biosensor for L-lactate analysis in wine and beer samples. Analyst. 2012 Aug 21;137(16):3854-61. doi: 10.1039/c2an35227c. Epub 2012 Jul 5. PubMed PMID: 22763889. 17: Huang L, Yu L, Chen Y. [Application of 1-ethyl-3-methyl imidazole L-lactate as the chiral ligand for the enantioseparation of amino acids]. Se Pu. 2014 Nov;32(11):1225-9. Chinese. PubMed PMID: 25764657. 18: Hildmann B, Storelli C, Haase W, Barac-Nieto M, Murer H. Sodium ion/L-lactate co-transport in rabbit small-intestinal brush-border-membrane vesicles. Biochem J. 1980 Jan 15;186(1):169-76. PubMed PMID: 7370006; PubMed Central PMCID: PMC1161516. 19: Sasaki S, Kobayashi M, Futagi Y, Ogura J, Yamaguchi H, Takahashi N, Iseki K. Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4). PLoS One. 2013 Jul 31;8(7):e67690. doi: 10.1371/journal.pone.0067690. Print 2013. PubMed PMID: 23935841; PubMed Central PMCID: PMC3729688. 20: Goran JM, Lyon JL, Stevenson KJ. Amperometric detection of L-lactate using nitrogen-doped carbon nanotubes modified with lactate oxidase. Anal Chem. 2011 Nov 1;83(21):8123-9. doi: 10.1021/ac2016272. Epub 2011 Oct 13. PubMed PMID: 21942440.