MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597380 | Name: beta-Casomorphin 7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

beta-Casomorphin 7 is an opioid peptide isolated from casein peptone; corresponds to sequence 60-66 of beta-casein; from a variety of organisms.

Chemical Structure

beta-Casomorphin 7
beta-Casomorphin 7
CAS#72122-62-4

Theoretical Analysis

MedKoo Cat#: 597380

Name: beta-Casomorphin 7

CAS#: 72122-62-4

Chemical Formula: C41H55N7O9

Exact Mass: 789.4061

Molecular Weight: 789.93

Elemental Analysis: C, 62.34; H, 7.02; N, 12.41; O, 18.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
beta-Casomorphin 7; Tyr-pro-phe-pro-gly-pro-ile;
IUPAC/Chemical Name
L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine
InChi Key
RKYJTDSQXOMDAD-JKXTZXEVSA-N
InChi Code
InChI=1S/C41H55N7O9/c1-3-25(2)35(41(56)57)45-38(53)32-13-7-19-46(32)34(50)24-43-36(51)31-12-8-21-48(31)40(55)30(23-26-10-5-4-6-11-26)44-37(52)33-14-9-20-47(33)39(54)29(42)22-27-15-17-28(49)18-16-27/h4-6,10-11,15-18,25,29-33,35,49H,3,7-9,12-14,19-24,42H2,1-2H3,(H,43,51)(H,44,52)(H,45,53)(H,56,57)/t25-,29-,30-,31-,32-,33-,35-/m0/s1
SMILES Code
CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CC5=CC=C(O)C=C5)N)=O)CCC4)=O)=O)CCC2)=O)=O)CCC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 789.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nguyen DD, Busetti F, Johnson SK, Solah VA. Degradation of β-casomorphins and identification of degradation products during yoghurt processing using liquid chromatography coupled with high resolution mass spectrometry. Food Res Int. 2018 Apr;106:98-104. doi: 10.1016/j.foodres.2017.12.035. Epub 2017 Dec 14. PubMed PMID: 29580012. 2: Zhu L, Li J, Wu D, Li B. The protective effect of beta-casomorphin-7 via promoting Foxo1 activity and nuclear translocation in human lens epithelial cells. Cutan Ocul Toxicol. 2018 Mar 27:1-8. doi: 10.1080/15569527.2018.1445095. [Epub ahead of print] PubMed PMID: 29519181. 3: Massella E, Piva S, Giacometti F, Liuzzo G, Zambrini AV, Serraino A. Evaluation of bovine beta casein polymorphism in two dairy farms located in northern Italy. Ital J Food Saf. 2017 Sep 29;6(3):6904. doi: 10.4081/ijfs.2017.6904. eCollection 2017 Aug 16. PubMed PMID: 29071248; PubMed Central PMCID: PMC5641661. 4: Nguyen DD, Busetti F, Johnson SK, Solah VA. Evaluation of a Commercial Sandwich Enzyme-Linked Immunosorbent Assay for the Quantification of Beta-Casomorphin 7 in Yogurt Using Solid-Phase Extraction Coupled to Liquid Chromatography-Tandem Mass Spectrometry as the "Gold Standard" Method. J AOAC Int. 2018 Mar 1;101(2):515-519. doi: 10.5740/jaoacint.17-0155. Epub 2017 Aug 1. PubMed PMID: 28766481. 5: Duarte-Vázquez MÁ, García-Ugalde C, Villegas-Gutiérrez LM, García-Almendárez BE, Rosado JL. Production of Cow's Milk Free from Beta-Casein A1 and Its Application in the Manufacturing of Specialized Foods for Early Infant Nutrition. Foods. 2017 Jul 12;6(7). pii: E50. doi: 10.3390/foods6070050. PubMed PMID: 28704923; PubMed Central PMCID: PMC5532557. 6: Chia JSJ, McRae JL, Kukuljan S, Woodford K, Elliott RB, Swinburn B, Dwyer KM. A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes. Nutr Diabetes. 2017 May 15;7(5):e274. doi: 10.1038/nutd.2017.16. Review. PubMed PMID: 28504710; PubMed Central PMCID: PMC5518798. 7: Fiedorowicz E, Markiewicz LH, Sidor K, Świątecka D, Cieślińska A, Matysiewicz M, Piskorz-Ogórek K, Sienkiewicz-Szłapka E, Teodorowicz M, Świątecki A, Kostyra E. The influence of breast milk and infant formulae hydrolysates on bacterial adhesion and Caco-2 cells functioning. Food Res Int. 2016 Nov;89(Pt 1):679-688. doi: 10.1016/j.foodres.2016.09.022. Epub 2016 Sep 28. PubMed PMID: 28460966. 8: Gholami M, Hafezian SH, Rahimi G, Farhadi A, Rahimi Z, Kahrizi D, Kiani S, Karim H, Vaziri S, Muhammadi S, Veisi F, Ghadiri K, Shetabi H, Zargooshi J. Allele specific-PCR and melting curve analysis showed relatively high frequency of β-casein gene A1 allele in Iranian Holstein, Simmental and native cows. Cell Mol Biol (Noisy-le-grand). 2016 Oct 31;62(12):138-143. doi: 10.14715/cmb/2016.62.12.23. PubMed PMID: 27894411. 9: Trivedi M, Zhang Y, Lopez-Toledano M, Clarke A, Deth R. Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes. J Nutr Biochem. 2016 Nov;37:39-46. doi: 10.1016/j.jnutbio.2015.10.012. Epub 2015 Nov 6. PubMed PMID: 27611101. 10: Deth R, Clarke A, Ni J, Trivedi M. Clinical evaluation of glutathione concentrations after consumption of milk containing different subtypes of β-casein: results from a randomized, cross-over clinical trial. Nutr J. 2016 Sep 29;15(1):82. PubMed PMID: 27680716; PubMed Central PMCID: PMC5041571. 11: Cattaneo S, Stuknytė M, Masotti F, De Noni I. Protein breakdown and release of β-casomorphins during in vitro gastro-intestinal digestion of sterilised model systems of liquid infant formula. Food Chem. 2017 Feb 15;217:476-482. doi: 10.1016/j.foodchem.2016.08.128. Epub 2016 Aug 31. PubMed PMID: 27664661. 12: Wang K, Han D, Zhang Y, Rong C, Zhang Y. [Protective effect and mechanism of β-CM7 on renin angiotensin system & diabetic cardiomyopathy]. Sheng Wu Gong Cheng Xue Bao. 2016 Feb;32(2):195-203. Chinese. PubMed PMID: 27382769. 13: Chu WT, Wang J. Energy Landscape Topography Reveals the Underlying Link Between Binding Specificity and Activity of Enzymes. Sci Rep. 2016 Jun 14;6:27808. doi: 10.1038/srep27808. PubMed PMID: 27298067; PubMed Central PMCID: PMC4906287. 14: Jianqin S, Leiming X, Lu X, Yelland GW, Ni J, Clarke AJ. Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk. Nutr J. 2016 Apr 2;15:35. doi: 10.1186/s12937-016-0147-z. Erratum in: Nutr J. 2016;15(1):45. PubMed PMID: 27039383; PubMed Central PMCID: PMC4818854. 15: Caroli AM, Savino S, Bulgari O, Monti E. Detecting β-Casein Variation in Bovine Milk. Molecules. 2016 Jan 25;21(2):141. doi: 10.3390/molecules21020141. PubMed PMID: 26821001. 16: Trivedi MS, Hodgson NW, Walker SJ, Trooskens G, Nair V, Deth RC. Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells. Nutr Metab (Lond). 2015 Dec 9;12:54. doi: 10.1186/s12986-015-0050-1. eCollection 2015. PubMed PMID: 26664459; PubMed Central PMCID: PMC4673759. 17: Pal S, Woodford K, Kukuljan S, Ho S. Milk Intolerance, Beta-Casein and Lactose. Nutrients. 2015 Aug 31;7(9):7285-97. doi: 10.3390/nu7095339. Review. PubMed PMID: 26404362; PubMed Central PMCID: PMC4586534. 18: Zhang W, Song S, Liu F, Liu Y, Zhang Y. Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: Involvement of AngII-TGF-β1 pathway. Peptides. 2015 Aug;70:37-44. doi: 10.1016/j.peptides.2015.04.002. Epub 2015 Apr 14. PubMed PMID: 25882007. 19: Parashar A, Rajput YS, Sharma R. Aptamer-based sensing of β-casomorphin-7. J Agric Food Chem. 2015 Mar 18;63(10):2647-53. doi: 10.1021/acs.jafc.5b00007. Epub 2015 Mar 10. PubMed PMID: 25712869. 20: Cieślińska A, Sienkiewicz-Szłapka E, Wasilewska J, Fiedorowicz E, Chwała B, Moszyńska-Dumara M, Cieśliński T, Bukało M, Kostyra E. Influence of candidate polymorphisms on the dipeptidyl peptidase IV and μ-opioid receptor genes expression in aspect of the β-casomorphin-7 modulation functions in autism. Peptides. 2015 Mar;65:6-11. doi: 10.1016/j.peptides.2014.11.012. Epub 2015 Jan 24. PubMed PMID: 25625371.