Synonym
Prolylisoleucine; Pro-ile;
IUPAC/Chemical Name
L-prolyl-L-isoleucine
InChi Key
OCYROESYHWUPBP-CIUDSAMLSA-N
InChi Code
InChI=1S/C11H20N2O3/c1-3-7(2)9(11(15)16)13-10(14)8-5-4-6-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)/t7-,8-,9-/m0/s1
SMILES Code
CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1NCCC1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
228.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li Y, Wang F, Zhang PZ, Yang M. [Chemical Constituents from Periplaneta americana]. Zhong Yao Cai. 2015 Oct;38(10):2038-41. Chinese. PubMed PMID: 27254913.
2: Paschoalin T, Carmona AK, Rodrigues EG, Oliveira V, Monteiro HP, Juliano MA, Juliano L, Travassos LR. Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Mol Cancer. 2007 Jul 9;6:44. PubMed PMID: 17620116; PubMed Central PMCID: PMC1965469.
3: Makarenko EIu, Kondrashev-Lugovskiĭ AS, Andreeva LA, Mart'ianov AA. [Effect of corticoliberin fragment CRF4-6 on blood glucose level and body temperature of rats]. Ross Fiziol Zh Im I M Sechenova. 2007 Jan;93(1):55-62. Russian. PubMed PMID: 17465274.
4: Makarenko EIu, Berdiev RK, Andreeva LA, Mart'ianov AA. [Epileptogenic activity of tripeptide corticotropin-releasing factor fragment (CRF(4-6))]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Nov-Dec;56(6):788-95. Russian. PubMed PMID: 17285774.
5: Makarenko EY, Andreeva LA, Mart'yanov AA. Effects of corticoliberin CRF(4-6) fragment on pain sensitivity in rats. Neurosci Behav Physiol. 2007 Jan;37(1):49-52. PubMed PMID: 17180318.
6: Makarenko EIu, Andreeva LA, Mart'ianov AA. [Effect of corticoliberin fragment CRF(4-6) on pain sensitivity in rats]. Ross Fiziol Zh Im I M Sechenova. 2005 Sep;91(9):1060-5. Russian. PubMed PMID: 16353480.
7: Andreev-Andrievskiĭ AA, Tsvirkun DV, Makarenko EIu, Andreeva LA, Mart'ianov AA. [Influence of corticotropin-releasing factor fragment CRF(4-6) on male rat sexual behaviour]. Ross Fiziol Zh Im I M Sechenova. 2005 Jul;91(7):785-90. Russian. PubMed PMID: 16206622.
8: Makarenko EIu, Tsvirkun DV, Andreeva LA, Martt'ianov AA. [Corticoliberin fragment CRF4-6 modifies rat behavior in opposite ways under stressing and non-stressing conditions]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 May-Jun;55(3):371-7. Russian. PubMed PMID: 16033239.
9: Makarenko EIu, Andreeva LA, Borovik AS, Mart'ianov AA. [Effect of the corticoliberin fragment CRF(4-6) on blood pressure and heart rate in rats]. Ross Fiziol Zh Im I M Sechenova. 2005 Jan;91(1):71-9. Russian. PubMed PMID: 15773582.
10: Makarenko EIu, Andreeva LA, Borovik AS, Mart'ianov AA. [Effect of a corticoliberin (CRF4-6) on the rat heart rate and behavior]. Ross Fiziol Zh Im I M Sechenova. 2003 Aug;89(8):943-50. Russian. PubMed PMID: 15119189.
11: Barnes K, Doherty S, Turner AJ. Endopeptidase-24.11 is the integral membrane peptidase initiating degradation of somatostatin in the hippocampus. J Neurochem. 1995 Apr;64(4):1826-32. PubMed PMID: 7891111.