MedKoo Cat#: 597376 | Name: Prolylisoleucine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prolylisoleucine is a derivative of isoleucine, an α-amino acid that is used in the biosynthesis of proteins.

Chemical Structure

Prolylisoleucine
Prolylisoleucine
CAS#51926-51-3

Theoretical Analysis

MedKoo Cat#: 597376

Name: Prolylisoleucine

CAS#: 51926-51-3

Chemical Formula: C11H20N2O3

Exact Mass: 228.1474

Molecular Weight: 228.29

Elemental Analysis: C, 57.87; H, 8.83; N, 12.27; O, 21.02

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Synonym
Prolylisoleucine; Pro-ile;
IUPAC/Chemical Name
L-prolyl-L-isoleucine
InChi Key
OCYROESYHWUPBP-CIUDSAMLSA-N
InChi Code
InChI=1S/C11H20N2O3/c1-3-7(2)9(11(15)16)13-10(14)8-5-4-6-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)/t7-,8-,9-/m0/s1
SMILES Code
CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1NCCC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Y, Wang F, Zhang PZ, Yang M. [Chemical Constituents from Periplaneta americana]. Zhong Yao Cai. 2015 Oct;38(10):2038-41. Chinese. PubMed PMID: 27254913. 2: Paschoalin T, Carmona AK, Rodrigues EG, Oliveira V, Monteiro HP, Juliano MA, Juliano L, Travassos LR. Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Mol Cancer. 2007 Jul 9;6:44. PubMed PMID: 17620116; PubMed Central PMCID: PMC1965469. 3: Makarenko EIu, Kondrashev-Lugovskiĭ AS, Andreeva LA, Mart'ianov AA. [Effect of corticoliberin fragment CRF4-6 on blood glucose level and body temperature of rats]. Ross Fiziol Zh Im I M Sechenova. 2007 Jan;93(1):55-62. Russian. PubMed PMID: 17465274. 4: Makarenko EIu, Berdiev RK, Andreeva LA, Mart'ianov AA. [Epileptogenic activity of tripeptide corticotropin-releasing factor fragment (CRF(4-6))]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Nov-Dec;56(6):788-95. Russian. PubMed PMID: 17285774. 5: Makarenko EY, Andreeva LA, Mart'yanov AA. Effects of corticoliberin CRF(4-6) fragment on pain sensitivity in rats. Neurosci Behav Physiol. 2007 Jan;37(1):49-52. PubMed PMID: 17180318. 6: Makarenko EIu, Andreeva LA, Mart'ianov AA. [Effect of corticoliberin fragment CRF(4-6) on pain sensitivity in rats]. Ross Fiziol Zh Im I M Sechenova. 2005 Sep;91(9):1060-5. Russian. PubMed PMID: 16353480. 7: Andreev-Andrievskiĭ AA, Tsvirkun DV, Makarenko EIu, Andreeva LA, Mart'ianov AA. [Influence of corticotropin-releasing factor fragment CRF(4-6) on male rat sexual behaviour]. Ross Fiziol Zh Im I M Sechenova. 2005 Jul;91(7):785-90. Russian. PubMed PMID: 16206622. 8: Makarenko EIu, Tsvirkun DV, Andreeva LA, Martt'ianov AA. [Corticoliberin fragment CRF4-6 modifies rat behavior in opposite ways under stressing and non-stressing conditions]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 May-Jun;55(3):371-7. Russian. PubMed PMID: 16033239. 9: Makarenko EIu, Andreeva LA, Borovik AS, Mart'ianov AA. [Effect of the corticoliberin fragment CRF(4-6) on blood pressure and heart rate in rats]. Ross Fiziol Zh Im I M Sechenova. 2005 Jan;91(1):71-9. Russian. PubMed PMID: 15773582. 10: Makarenko EIu, Andreeva LA, Borovik AS, Mart'ianov AA. [Effect of a corticoliberin (CRF4-6) on the rat heart rate and behavior]. Ross Fiziol Zh Im I M Sechenova. 2003 Aug;89(8):943-50. Russian. PubMed PMID: 15119189. 11: Barnes K, Doherty S, Turner AJ. Endopeptidase-24.11 is the integral membrane peptidase initiating degradation of somatostatin in the hippocampus. J Neurochem. 1995 Apr;64(4):1826-32. PubMed PMID: 7891111.