Synonym
Isoidide mononitrate; L-Iimn; L-Isoidide-2-mononitrate;
IUPAC/Chemical Name
(3R,3aS,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate
InChi Key
YWXYYJSYQOXTPL-KVTDHHQDSA-N
InChi Code
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4-,5-,6-/m1/s1
SMILES Code
O=[N+]([O-])O[C@H](CO1)[C@@H]2[C@H]1[C@H](O)CO2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
191.13
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hatanaka T, Ihara K, Kodera M, Katayama K, Koizumi T. Stereoselective pharmacokinetics and pharmacodynamics of organic nitrates in rats. J Pharmacol Exp Ther. 2001 Jul;298(1):346-53. PubMed PMID: 11408561.
2: Ratz JD, McGuire JJ, Bennett BM. Enantioselective inhibition of the biotransformation and pharmacological actions of isoidide dinitrate by diphenyleneiodonium sulphate. Br J Pharmacol. 1999 Jan;126(1):61-8. PubMed PMID: 10051121; PubMed Central PMCID: PMC1565779.
3: Tzeng TB, Fung HL. Pharmacokinetics of oral L-isoidide mononitrate in rats. Biopharm Drug Dispos. 1993 Oct;14(7):589-94. PubMed PMID: 8251613.
4: Tzeng TB, Fung HL. Pharmacokinetics of stereomeric 1,4:3,6-dianhydrohexitol mononitrates in rats. Pharm Res. 1993 Jan;10(1):22-7. PubMed PMID: 8430056.
5: Tzeng TB, Fung HL. Pharmacodynamic modeling of the in vitro vasodilating effects of organic mononitrates. J Pharmacokinet Biopharm. 1992 Jun;20(3):227-51. PubMed PMID: 1326039.
6: Tzeng TB, Fung HL. Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats. J Pharmacol Exp Ther. 1992 May;261(2):692-700. PubMed PMID: 1578380.
7: Tzeng TB, Fung HL. Gas chromatographic analysis of isomeric organic mononitrates in plasma. J Chromatogr. 1991 Nov 15;571(1-2):109-20. PubMed PMID: 1810940.
8: Stewart DH, Hayward LD, Bennett BM. Differential biotransformation of the enantiomers of isoidide dinitrate in isolated rat aorta. Can J Physiol Pharmacol. 1989 Nov;67(11):1403-8. PubMed PMID: 2627680.
9: Santoni Y, Rolland PH, Cano JP. Determination of isosorbide dinitrate and its mononitrate metabolites in human plasma using Extrelut purification and capillary column gas-liquid chromatography. J Chromatogr. 1984 Mar 9;306:165-72. PubMed PMID: 6715456.
