IUPAC/Chemical Name
(2-(((S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl)amino)ethyl)-L-arginine
InChi Key
LLPMPMKLOHAIMY-QWRGUYRKSA-N
InChi Code
InChI=1S/C14H25N7O4/c15-14(16)20-3-1-2-10(12(22)23)18-4-5-19-11(13(24)25)6-9-7-17-8-21-9/h7-8,10-11,18-19H,1-6H2,(H,17,21)(H,22,23)(H,24,25)(H4,15,16,20)/t10-,11-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CNC=N1)NCCN[C@H](C(O)=O)CCCNC(N)=N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
355.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ito Y, Mizutani S, Kurauchi O, Kasugai M, Narita O, Tomoda Y. Purification and properties of microsomal carboxypeptidase N (kininase I) in human placenta. Enzyme. 1989;42(1):8-14. PubMed PMID: 2776715.
2: Wada T, Aoyagi T. Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling. Adv Exp Med Biol. 1989;247A:191-5. PubMed PMID: 2557740.
3: Moriguchi M, Umeda Y, Miyazaki K, Nakamura T, Ogawa K, Kojima F, Iinuma H, Aoyagi T. Synthesis of histargin and related compounds and their inhibition of enzymes. J Antibiot (Tokyo). 1988 Dec;41(12):1823-7. PubMed PMID: 3209475.
4: Wada T, Aoyagi T, Iinuma H, Ogawa K, Kojima F, Nagai M, Kuroda H, Obayashi A, Takeuchi T. Feedback analysis of the behavior of the renin-angiotensin system under inhibition of angiotensin-converting enzyme. Biotechnol Appl Biochem. 1988 Oct;10(5):435-46. PubMed PMID: 3058152.
5: Ogawa K, Naganawa H, Iinuma H, Aoyagi T, Umezawa H. The structure of histargin. J Antibiot (Tokyo). 1984 Sep;37(9):984-7. PubMed PMID: 6548740.
6: Umezawa H, Aoyagi T, Ogawa K, Iinuma H, Naganawa H, Hamada M, Takeuchi T. Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes. J Antibiot (Tokyo). 1984 Sep;37(9):1088-90. PubMed PMID: 6548739.
