Synonym
MHY884; MHY-884; MHY 884;
IUPAC/Chemical Name
4-(5-Chloro-2,3-dihydrobenzo[d]thiazol-2-yl)-2,6-dimethoxyphenol
InChi Key
LQDWIAAYFSZPAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14ClNO3S/c1-19-11-5-8(6-12(20-2)14(11)18)15-17-10-7-9(16)3-4-13(10)21-15/h3-7,15,17-18H,1-2H3
SMILES Code
OC1=C(OC)C=C(C2SC3=CC=C(Cl)C=C3N2)C=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
323.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Choi YJ, Uehara Y, Park JY, Kim SJ, Kim SR, Lee HW, Moon HR, Chung HY. MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1344-8. doi: 10.1016/j.bmcl.2014.01.040. Epub 2014 Jan 25. PubMed PMID: 24508132. 2: Ha YM, Uehara Y, Park D, Jeong HO, Park JY, Park YJ, Lee JY, Lee HJ, Song YM, Moon HR, Chung HY. Synthesis and preliminary in vitro biological evaluation of 5-chloro-2-(substituted phenyl)benzo[d]thiazole derivatives designed as novel antimelanogenesis agents. Appl Biochem Biotechnol. 2012 Nov;168(6):1416-33. doi: 10.1007/s12010-012-9867-5. Epub 2012 Sep 12. PubMed PMID: 22968587.
