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MedKoo Cat#: 591858 | Name: Phenyl butyrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenyl butyrate non-selective ERS inhibitor that attenuates angiotensin II-induced abdominal aortic aneurysm

Chemical Structure

Phenyl butyrate
Phenyl butyrate
CAS#4346-18-3

Theoretical Analysis

MedKoo Cat#: 591858

Name: Phenyl butyrate

CAS#: 4346-18-3

Chemical Formula: C10H12O2

Exact Mass: 164.0837

Molecular Weight: 164.20

Elemental Analysis: C, 73.15; H, 7.37; O, 19.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Phenyl butyrate; AI3-11761; AI3 11761; AI311761
IUPAC/Chemical Name
Butanoic acid, phenyl ester
InChi Key
IGVPBCZDHMIOJH-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12O2/c1-2-6-10(11)12-9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
SMILES Code
CCCC(OC1=CC=CC=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 164.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ni XQ, Lu WW, Zhang JS, Zhu Q, Ren JL, Yu YR, Liu XY, Wang XJ, Han M, Jing Q, Du J, Tang CS, Qi YF. Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice. Endocrine. 2018 Jun 26. doi: 10.1007/s12020-018-1657-6. [Epub ahead of print] PubMed PMID: 29943223. 2: Huang B, Siqueira WL, Cvitkovitch DG, Finer Y. Esterase from a cariogenic bacterium hydrolyzes dental resins. Acta Biomater. 2018 Apr 15;71:330-338. doi: 10.1016/j.actbio.2018.02.020. Epub 2018 Mar 1. PubMed PMID: 29496621; PubMed Central PMCID: PMC5899954. 3: Estévez RA, Mostazo MGC, Rodriguez E, Espinoza JC, Kuznar J, Jónsson ZO, Guðmundsson GH, Maier VH. Inducers of salmon innate immunity: An in vitro and in vivo approach. Fish Shellfish Immunol. 2018 Jan;72:247-258. doi: 10.1016/j.fsi.2017.10.058. Epub 2017 Nov 8. PubMed PMID: 29108970. 4: Wiersma M, Meijering RAM, Qi XY, Zhang D, Liu T, Hoogstra-Berends F, Sibon OCM, Henning RH, Nattel S, Brundel BJJM. Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation. J Am Heart Assoc. 2017 Oct 24;6(10). pii: e006458. doi: 10.1161/JAHA.117.006458. PubMed PMID: 29066441; PubMed Central PMCID: PMC5721854. 5: Watanabe B, Tabuchi Y, Wada K, Hiratake J. Synthesis and evaluation of the inhibitory activity of the four stereoisomers of the potent and selective human γ-glutamyl transpeptidase inhibitor GGsTop. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4920-4924. doi: 10.1016/j.bmcl.2017.09.017. Epub 2017 Sep 8. PubMed PMID: 28985998. 6: Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. PubMed PMID: 28759231. 7: S N C S, Bhurta D, Kantiwal D, George G, Monga V, Paul AT. Design, synthesis, biological evaluation and molecular modelling studies of novel diaryl substituted pyrazolyl thiazolidinediones as potent pancreatic lipase inhibitors. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3749-3754. doi: 10.1016/j.bmcl.2017.06.069. Epub 2017 Jun 28. PubMed PMID: 28705641. 8: Legastelois R, Jeanblanc J, Vilpoux C, Bourguet E, Naassila M. [Epigenetic mechanisms and alcohol use disorders: a potential therapeutic target]. Biol Aujourdhui. 2017;211(1):83-91. doi: 10.1051/jbio/2017014. Epub 2017 Jul 6. Review. French. PubMed PMID: 28682229. 9: Xue P, Zeng F, Duan Q, Xiao J, Liu L, Yuan P, Fan L, Sun H, Malyarenko OS, Lu H, Xiu R, Liu S, Shao C, Zhang J, Yan W, Wang Z, Zheng J, Zhu F. BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer. EBioMedicine. 2017 Jun;20:50-60. doi: 10.1016/j.ebiom.2017.05.001. Epub 2017 May 4. PubMed PMID: 28501528; PubMed Central PMCID: PMC5478211. 10: Nguyen LT, Saad S, Tan Y, Pollock C, Chen H. Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus. J Mol Endocrinol. 2017 Jul;59(1):81-92. doi: 10.1530/JME-17-0056. Epub 2017 May 12. PubMed PMID: 28500249. 11: Zhang W, Zhang SL, Hu X, Tam KY. Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect. Eur J Pharm Sci. 2017 Dec 15;110:93-100. doi: 10.1016/j.ejps.2017.04.018. Epub 2017 Apr 25. PubMed PMID: 28450154. 12: Soni S, Sathe SS, Odaneth AA, Lali AM, Chandrayan SK. SGNH hydrolase-type esterase domain containing Cbes-AcXE2: a novel and thermostable acetyl xylan esterase from Caldicellulosiruptor bescii. Extremophiles. 2017 Jul;21(4):687-697. doi: 10.1007/s00792-017-0934-2. Epub 2017 Apr 25. PubMed PMID: 28444450. 13: Sekioka T, Kadode M, Osakada N, Fujita M, Matsumura N, Yamaura Y, Nakade S, Nabe T, Kawabata K. A new CysLT(1) and CysLT(2) receptors-mediated anaphylaxis guinea pig model. Prostaglandins Leukot Essent Fatty Acids. 2017 Apr;119:18-24. doi: 10.1016/j.plefa.2017.03.002. Epub 2017 Mar 8. PubMed PMID: 28410666. 14: Salah M, Komiha N, Kabbaj OK, Ghailane R, Marakchi K. Computational study of the 1,3-dipolar cycloaddition between methyl 2-trifluorobutynoate and substituted azides in terms of reactivity indices and activation parameters. J Mol Graph Model. 2017 May;73:143-151. doi: 10.1016/j.jmgm.2017.02.017. Epub 2017 Mar 1. PubMed PMID: 28279822. 15: Mollica MP, Mattace Raso G, Cavaliere G, Trinchese G, De Filippo C, Aceto S, Prisco M, Pirozzi C, Di Guida F, Lama A, Crispino M, Tronino D, Di Vaio P, Berni Canani R, Calignano A, Meli R. Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice. Diabetes. 2017 May;66(5):1405-1418. doi: 10.2337/db16-0924. Epub 2017 Feb 21. PubMed PMID: 28223285. 16: Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, Ikari A. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017 Feb 10;292(6):2411-2421. doi: 10.1074/jbc.M116.762807. Epub 2017 Jan 5. PubMed PMID: 28057758; PubMed Central PMCID: PMC5313110. 17: Virgen-Ortíz JJ, Tacias-Pascacio VG, Hirata DB, Torrestiana-Sanchez B, Rosales-Quintero A, Fernandez-Lafuente R. Relevance of substrates and products on the desorption of lipases physically adsorbed on hydrophobic supports. Enzyme Microb Technol. 2017 Jan;96:30-35. doi: 10.1016/j.enzmictec.2016.09.010. Epub 2016 Sep 20. PubMed PMID: 27871382. 18: Hettmanczyk L, Schmid B, Hohloch S, Sarkar B. Palladium(ii)-Acetylacetonato Complexes with Mesoionic Carbenes: Synthesis, Structures and Their Application in the Suzuki-Miyaura Cross Coupling Reaction. Molecules. 2016 Nov 17;21(11). pii: E1561. PubMed PMID: 27869699. 19: Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero-Melendez T, Berni Canani R, Calignano A, Perretti M, Meli R. An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis. Br J Pharmacol. 2017 Jun;174(11):1484-1496. doi: 10.1111/bph.13637. Epub 2016 Nov 3. PubMed PMID: 27684049; PubMed Central PMCID: PMC5429328. 20: Carelli S, Giallongo T, Viaggi C, Gombalova Z, Latorre E, Mazza M, Vaglini F, Di Giulio AM, Gorio A. Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice. ASN Neuro. 2016 Oct 27;8(5). pii: 1759091416676147. Print 2016 Oct. PubMed PMID: 27789613; PubMed Central PMCID: PMC5102092.

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