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MedKoo Cat#: 597281 | Name: Glutaurine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glutaurine is a recently deteccted hormone of parathyroid gland. Glutaurine has been observed to display antiepileptic effects with anti-amnesia properties. Mimics anxiolytic drug Diazepam.

Chemical Structure

Glutaurine
Glutaurine
CAS#56488-60-9

Theoretical Analysis

MedKoo Cat#: 597281

Name: Glutaurine

CAS#: 56488-60-9

Chemical Formula: C7H14N2O6S

Exact Mass: 254.0573

Molecular Weight: 254.25

Elemental Analysis: C, 33.07; H, 5.55; N, 11.02; O, 37.75; S, 12.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Glutaurine; gamma-Glutamyltaurine; Litoralon;
IUPAC/Chemical Name
(2-sulfoethyl)-L-glutamine
InChi Key
LONRGKAJEPECOB-YFKPBYRVSA-N
InChi Code
InChI=1S/C7H14N2O6S/c8-6(10)2-1-5(7(11)12)9-3-4-16(13,14)15/h5,9H,1-4H2,(H2,8,10)(H,11,12)(H,13,14,15)/t5-/m0/s1
SMILES Code
O=C(N)CC[C@@H](C(O)=O)NCCS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bittner S, Win T, Gupta R. gamma-L-glutamyltaurine. Amino Acids. 2005 Jun;28(4):343-56. Epub 2005 Apr 21. Review. PubMed PMID: 15838590. 2: Suzuki H, Izuka S, Minami H, Miyakawa N, Ishihara S, Kumagai H. Use of bacterial gamma-glutamyltranspeptidase for enzymatic synthesis of gamma-D-glutamyl compounds. Appl Environ Microbiol. 2003 Nov;69(11):6399-404. PubMed PMID: 14602592; PubMed Central PMCID: PMC262288. 3: Durlach J, Bac P, Bara M, Guiet-Bara A. Physiopathology of symptomatic and latent forms of central nervous hyperexcitability due to magnesium deficiency: a current general scheme. Magnes Res. 2000 Dec;13(4):293-302. Review. PubMed PMID: 11153899. 4: Varga V, Janáky R, Takáts A, Oja SS, Dohovics R, Rechardt L. Interaction of gamma-L-glutamyltaurine with kainate-induced cyclic AMP formation in the rat hippocampus. Adv Exp Med Biol. 1996;403:473-9. PubMed PMID: 8915385. 5: Varga V, Janáky R, Marnela KM, Saransaari P, Oja SS. Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission. Neurochem Res. 1994 Mar;19(3):243-8. PubMed PMID: 7909918. 6: Uemura S, Ienaga K, Higashiura K, Kimura H. Gamma-glutamyltaurine has potent and long-lasting antiepileptic action as demonstrated by intra-amygdaloid injection in amygdala-kindled rats. Brain Res. 1992 Oct 30;594(2):347-50. PubMed PMID: 1450962. 7: Andiné P, Orwar O, Jacobson I, Sandberg M, Hagberg H. Extracellular acidic sulfur-containing amino acids and gamma-glutamyl peptides in global ischemia: postischemic recovery of neuronal activity is paralleled by a tetrodotoxin-sensitive increase in cysteine sulfinate in the CA1 of the rat hippocampus. J Neurochem. 1991 Jul;57(1):230-6. PubMed PMID: 2051166. 8: Gergely P. Treatment of autoimmune patients. Acta Biomed Ateneo Parmense. 1991;62(3-4):125-30. PubMed PMID: 1840372. 9: Nakamura K, Higashiura K, Nishimura N, Yamamoto A, Tooyama I, Kimura H, Ienaga K. Isolation of glutamyltaurine from bovine brains and proof of its gamma-linkage by the B/E linked scan SIMS technique. J Neurochem. 1990 Sep;55(3):1064-6. PubMed PMID: 2384748. 10: Varga V, Janáky R, Holopainen I, Kontro P, Oja SS. Effect of glutamyltaurine on calcium influx in cultured cerebellar granule cells. Prog Clin Biol Res. 1990;351:141-5. PubMed PMID: 2236122. 11: Horne AL, Simmonds MA. The pharmacology of quisqualate and AMPA in the cerebral cortex of the rat in vitro. Neuropharmacology. 1989 Oct;28(10):1113-8. PubMed PMID: 2682343. 12: Tóth S, Csaba G. gamma-L-glutamyl-taurine (Litoralon) prevents the micronucleus formation induced by mitomycin C. Mutat Res. 1988 Sep-Oct;209(1-2):85-9. PubMed PMID: 3140006. 13: Balázs M, Telegdy G. Effects of glutaurine treatment on electroshock-induced amnesia. Antiamnesic action of glutaurine. Neuropeptides. 1988 Aug-Sep;12(2):55-8. PubMed PMID: 3185869. 14: Schulz H. Spatial working memory in rats: the effect of the dipeptide gamma-L-glutamyl-taurine and haloperidol. Acta Physiol Hung. 1988;72(3-4):263-7. PubMed PMID: 3250206. 15: Marnela KM, Varga V, Dibó G, Lähdesmäki P. Position of the peptide linkage in glutamyl-taurine from calf brain synaptic vesicles. J Neurochem. 1987 Apr;48(4):1090-2. PubMed PMID: 3819721. 16: Baskin S, Bartuska D, Thampi N, McBride M, Finnigan J. The effect of glutaurine on thyroid hormones in the rat. Neuropeptides. 1987 Jan;9(1):45-50. PubMed PMID: 3561723. 17: Toldi J, Fehér O. Interactions of acoustic and somatosensory evoked responses in a polysensory cortex of the cat. Acta Biol Hung. 1987;38(3-4):333-48. PubMed PMID: 3503441. 18: Kovács P, Csaba G, Köhidai L, Török O. Adaptation of the ASTRIN staining technique for quantitative determination of the functional state of the cellular nucleus. Experiments on the nucleoli of CHO cells. Acta Histochem. 1987;81(1):95-8. PubMed PMID: 2436430. 19: Stephens RL Jr, Lee T, Boldry R, Uretsky NJ. Activation of excitatory amino acid receptors may mediate the folate-induced stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. J Pharmacol Exp Ther. 1986 Dec;239(3):627-33. PubMed PMID: 3025414. 20: Schulz H, Feuer L. Gamma-L-glutamyl-taurine (Litoralon) affects conditioned taste aversion in rats. Acta Physiol Hung. 1986;67(2):233-42. PubMed PMID: 3739747.