Aceglutamide | CAS#2490-97-3 | psychostimulant

MedKoo Cat#: 597275 | Name: Aceglutamide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aceglutamide is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia.

Chemical Structure

Aceglutamide

CAS#2490-97-3

Theoretical Analysis

MedKoo Cat#: 597275

Name: Aceglutamide

CAS#: 2490-97-3

Chemical Formula: C7H12N2O4

Exact Mass: 188.0797

Molecular Weight: 188.18

Elemental Analysis: C, 44.68; H, 6.43; N, 14.89; O, 34.01

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 weeks

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Related CAS #

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Synonym

Aceglutamide; Acetylglutamine; NSC 186896; NSC-186896; NSC186896; N(sup2)-Acetyl-L-glutamine; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

IUPAC/Chemical Name

acetyl-L-glutamine

InChi Key

KSMRODHGGIIXDV-YFKPBYRVSA-N

InChi Code

InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1

SMILES Code

O=C(N)CC[C@@H](C(O)=O)NC(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 188.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fang YC, Wan HT, Yu L, Yin F, Yang JH, Zhou HF, He Y. [Pharmacokinetics of main activ ingredients of Guhong injection in cerebral ischemia rats]. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1940-1945. doi: 10.19540/j.cnki.cjcmm.20180206.001. Chinese. PubMed PMID: 29902908. 2: Yu L, Wan HF, Li C, Yang JH, Zhou HF, Wan HT, He Y. Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study. Front Pharmacol. 2018 May 15;9:493. doi: 10.3389/fphar.2018.00493. eCollection 2018. PubMed PMID: 29867497; PubMed Central PMCID: PMC5962683. 3: Li D, Chen YG, Zhang CJ, Tian J, Li X. Safflower Extract and Aceglutamide Injection Promoting Recovery of Peripheral Innervations via Vascular Endothelial Growth Factor-B Signaling in Diabetic Mice. Chin Med J (Engl). 2017 Dec 5;130(23):2829-2835. doi: 10.4103/0366-6999.219143. PubMed PMID: 29176141; PubMed Central PMCID: PMC5717862. 4: Ai J, Wan H, Shu M, Zhou H, Zhao T, Fu W, He Y. Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats. Arch Pharm Res. 2017 May;40(5):610-622. doi: 10.1007/s12272-016-0835-4. Epub 2016 Sep 13. PubMed PMID: 27624481. 5: Zhang R, Yang N, Ji C, Zheng J, Liang Z, Hou CY, Liu YY, Zuo PP. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2015;33(5):741-59. doi: 10.3233/RNN-150509. PubMed PMID: 26444640. 6: Wang D, Wu S. Development and validation of a RP-HPLC method for the simultaneous determination of aceglutamide and oxiracetam in an injection formulation. J Chromatogr Sci. 2015 May-Jun;53(5):767-70. doi: 10.1093/chromsci/bmu123. Epub 2014 Sep 19. PubMed PMID: 25238766. 7: Pekkala S, Martínez AI, Barcelona B, Yefimenko I, Finckh U, Rubio V, Cervera J. Understanding carbamoyl-phosphate synthetase I (CPS1) deficiency by using expression studies and structure-based analysis. Hum Mutat. 2010 Jul;31(7):801-8. doi: 10.1002/humu.21272. PubMed PMID: 20578160. 8: López-Pedrosa JM, Manzano M, Baxter JH, Rueda R. N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs. Dig Dis Sci. 2007 Mar;52(3):650-8. PubMed PMID: 17253138. 9: Arnaud A, Ramírez M, Baxter JH, Angulo AJ. Absorption of enterally administered N-acetyl-l-glutamine versus glutamine in pigs. Clin Nutr. 2004 Dec;23(6):1303-12. PubMed PMID: 15556252. 10: Racine SX, Le Toumelin P, Adnet F, Cohen Y, Cupa M, Hantz E, Le Moyec L. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron Physiol. 2004;97(4):p53-7. 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