Synonym
Splenotritin; Thymopoietin tripeptide; TP-3; TP 3; TP3;
IUPAC/Chemical Name
L-arginyl-L-lysyl-L-glutamic acid
InChi Key
CVXXSWQORBZAAA-SRVKXCTJSA-N
InChi Code
InChI=1S/C17H33N7O6/c18-8-2-1-5-11(15(28)24-12(16(29)30)6-7-13(25)26)23-14(27)10(19)4-3-9-22-17(20)21/h10-12H,1-9,18-19H2,(H,23,27)(H,24,28)(H,25,26)(H,29,30)(H4,20,21,22)/t10-,11-,12-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
431.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Huang HN, Chan YL, Hui CF, Wu JL, Wu CJ, Chen JY. Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries. Oncotarget. 2015 May 30;6(15):12955-69. PubMed PMID: 25992774; PubMed Central PMCID: PMC4536991.
2: Onda M, Bruland ØS, Pastan I. TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma. Clin Orthop Relat Res. 2005 Jan;(430):142-8. PubMed PMID: 15662316.
3: Kvinnsland Y, Stokke T, Aurlien E. Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei. Radiat Res. 2001 Feb;155(2):288-96. PubMed PMID: 11175663.
4: Ek O, Waurzyniak B, Myers DE, Uckun FM. Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma. Clin Cancer Res. 1998 Jul;4(7):1641-7. PubMed PMID: 9676838.
5: Simon HU, Forner K, Büttner A, Haroske D, Vogt KH. [The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides]. Pharmazie. 1990 Dec;45(12):917-9. German. PubMed PMID: 2100799.
6: Dénes L, Hajós G, Szporny L, Szende B, Lapis K, Sipka S, Szegedi G. The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs. Immunol Invest. 1987 Jun;16(4):275-9. PubMed PMID: 3323037.
7: Dénes L, Szende B, Hajós G, Szporny L, Lapis K. Therapeutic possibilities of thymopoietin fragments (TP3 and TP4) based on experimental animal models. Drugs Exp Clin Res. 1987;13(5):279-87. PubMed PMID: 3500029.
8: Diezel W, Eckert R, Forner K, Gruner S. Functional effects of splenin32-34 on antibody formation in immunosuppressed mice. Biomed Biochim Acta. 1986;45(10):1349-52. PubMed PMID: 3551932.
