Synonym
LMPTP-IN-23; LMPTP-IN 23; LMPTP-IN23; MDK-4823; MDK 4823; MDK4823; LMPTP inhibitor1; LMPTP inhibitor-1.
IUPAC/Chemical Name
N,N-Diethyl-4-[4-(3-piperidin-1-yl-propylamino)-quinolin-2-yl]-benzamide
InChi Key
XISMYRQHGUUMGY-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H36N4O/c1-3-32(4-2)28(33)23-15-13-22(14-16-23)26-21-27(24-11-6-7-12-25(24)30-26)29-17-10-20-31-18-8-5-9-19-31/h6-7,11-16,21H,3-5,8-10,17-20H2,1-2H3,(H,29,30)
SMILES Code
O=C(N(CC)CC)C1=CC=C(C2=NC3=CC=CC=C3C(NCCCN4CCCCC4)=C2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
444.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Feng B, Dong X, Liu Z, Zhang J, Liu H, Xu Y. Virtual Screening and Biological
Evaluation of Novel Low Molecular Weight Protein Tyrosine Phosphatase Inhibitor
for the Treatment of Insulin Resistance. Drug Des Devel Ther. 2023 Apr
21;17:1191-1201. doi: 10.2147/DDDT.S406956. PMID: 37113468; PMCID: PMC10128076.
2: Alicka M, Kornicka-Garbowska K, Roecken M, Marycz K. Inhibition of the Low
Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic
Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication. Int J
Mol Sci. 2019 Nov 22;20(23):5873. doi: 10.3390/ijms20235873. PMID: 31771123;
PMCID: PMC6928870.
3: Kornicka-Garbowska K, Bourebaba L, Röcken M, Marycz K. Inhibition of protein
tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces
oxidative stress, and enhances adipogenic differentiation potential in
metabolically impaired progenitor stem cells. Cell Commun Signal. 2021 Nov
3;19(1):106. doi: 10.1186/s12964-021-00772-5. Erratum in: Cell Commun Signal.
2023 Jan 20;21(1):12. doi: 10.1186/s12964-023-01055-x. PMID: 34732209; PMCID:
PMC8565043.
4: Bourebaba L, Łyczko J, Alicka M, Bourebaba N, Szumny A, Fal AM, Marycz K.
Inhibition of Protein-tyrosine Phosphatase PTP1B and LMPTP Promotes
Palmitate/Oleate-challenged HepG2 Cell Survival by Reducing Lipoapoptosis,
Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic
Reticulum Stress. J Clin Med. 2020 May 1;9(5):1294. doi: 10.3390/jcm9051294.
PMID: 32369900; PMCID: PMC7288314.
