MedKoo Cat#: 563132 | Name: 10-Cl-BBQ
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

10-Cl-BBQ is an aryl hydrocarbon receptor (AhR) ligand.

Chemical Structure

10-Cl-BBQ
10-Cl-BBQ
CAS#23982-76-5

Theoretical Analysis

MedKoo Cat#: 563132

Name: 10-Cl-BBQ

CAS#: 23982-76-5

Chemical Formula: C18H9ClN2O

Exact Mass: 304.0403

Molecular Weight: 304.73

Elemental Analysis: C, 70.95; H, 2.98; Cl, 11.63; N, 9.19; O, 5.25

Price and Availability

Size Price Availability Quantity
5mg USD 285.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
10-Cl-BBQ; 10 Cl BBQ; 10ClBBQ;
IUPAC/Chemical Name
10-Chloro-7H-benzimidazo[2,1-a]benzo[de]Iso-quinolin-7-one
InChi Key
ZJESJVGSDQOZAT-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H9ClN2O/c19-11-7-8-14-15(9-11)21-17(20-14)12-5-1-3-10-4-2-6-13(16(10)12)18(21)22/h1-9H
SMILES Code
O=C(C1=CC=CC2=CC=CC3=C12)N4C3=NC5=CC=C(Cl)C=C54
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ehrlich AK, Pennington JM, Wang X, Rohlman D, Punj S, Löhr CV, Newman MT, Kolluri SK, Kerkvliet NI. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73. doi: 10.4049/jimmunol.1501789. Epub 2015 Nov 16. PubMed PMID: 26573835; PubMed Central PMCID: PMC4684970. 2: Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726. eCollection 2014. PubMed PMID: 24586378; PubMed Central PMCID: PMC3929365.