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MedKoo Cat#: 591803 | Name: Pindone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pindone, also known as NSC 31211, is an anticoagulant drug for agricultural use with noted antioxidant, anti-inflammatory, and anti-apoptotic activities. Pinocembrin markedly reduced the elevation in serum C-reactive protein (CRP) level induced by L-arginine.

Chemical Structure

Pindone
Pindone
CAS#83-26-1

Theoretical Analysis

MedKoo Cat#: 591803

Name: Pindone

CAS#: 83-26-1

Chemical Formula: C14H14O3

Exact Mass: 230.0943

Molecular Weight: 230.26

Elemental Analysis: C, 73.03; H, 6.13; O, 20.84

Price and Availability

Size Price Availability Quantity
250g USD 400.00
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Related CAS #
No Data
Synonym
NSC 31211; NSC-31211; NSC31211; Pindone;
IUPAC/Chemical Name
1,3-Indandione, 2-pivaloyl-
InChi Key
RZKYEQDPDZUERB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3
SMILES Code
O=C1C(C(C(C)(C)C)=O)C(C2=C1C=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Pindone is an anticoagulant drug for agricultural use.
In vitro activity:
TBD
In vivo activity:
The effect of the anticoagulant, pindone, on the breeding performance and survival of relatively free-ranging merino sheep was assessed. The breeding performance of pregnant ewes dosed with pindone was reduced, mainly due to an increase in stillborn and nonviable lambs (i.e. deaths within 2 days of birth). The motility of sperm in treated rams was also affected. Pindone persisted in the blood (maximum, 13.2 mg L(-1)) for up to 14 days after the last dose, and the half-life (t1/2) was estimated at approximately 5 days depending upon the dosing regime. Reference: Comp Biochem Physiol B Biochem Mol Biol. 2005 Mar;140(3):465-73. https://pubmed.ncbi.nlm.nih.gov/15694595/

Preparing Stock Solutions

The following data is based on the product molecular weight 230.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Robinson MH, Twigg LE, Wheeler SH, Martin GR. Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries. Comp Biochem Physiol B Biochem Mol Biol. 2005 Mar;140(3):465-73. doi: 10.1016/j.cbpc.2004.11.011. PMID: 15694595. 2. Martin GR, Sutherland RJ, Robertson ID, Kirkpatrick WE, King DR, Hood PJ. Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals. Aust Vet J. 1991 Jul;68(7):241-3. doi: 10.1111/j.1751-0813.1991.tb03217.x. Erratum in: Aust Vet J 1992 Jul;69(7):176. PMID: 1929992.
In vitro protocol:
TBD
In vivo protocol:
1. Robinson MH, Twigg LE, Wheeler SH, Martin GR. Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries. Comp Biochem Physiol B Biochem Mol Biol. 2005 Mar;140(3):465-73. doi: 10.1016/j.cbpc.2004.11.011. PMID: 15694595. 2. Martin GR, Sutherland RJ, Robertson ID, Kirkpatrick WE, King DR, Hood PJ. Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals. Aust Vet J. 1991 Jul;68(7):241-3. doi: 10.1111/j.1751-0813.1991.tb03217.x. Erratum in: Aust Vet J 1992 Jul;69(7):176. PMID: 1929992.
1: Qiao Z, Xiang P, Shen B, Shen M, Yan H. Simultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography-Tandem Mass Spectrometry and its Application in Three Poisoning Cases. J Forensic Sci. 2018 May;63(3):784-792. doi: 10.1111/1556-4029.13613. PubMed PMID: 29723420. 2: Lohr MT, Davis RA. Anticoagulant rodenticide use, non-target impacts and regulation: A case study from Australia. Sci Total Environ. 2018 Sep 1;634:1372-1384. doi: 10.1016/j.scitotenv.2018.04.069. Epub 2018 Apr 18. Review. PubMed PMID: 29710637. 3: Saito-Shida S, Nemoto S, Matsuda R, Akiyama H. Simultaneous determination of seven anticoagulant rodenticides in agricultural products by gel permeation chromatography and liquid chromatography-tandem mass spectrometry. J Environ Sci Health B. 2016 Nov;51(11):801-8. doi: 10.1080/03601234.2016.1198654. Epub 2016 Jul 18. PubMed PMID: 27428755. 4: Fisher P, Brown S, Arrow J. Welfare Impacts of Pindone Poisoning in Rabbits (Oryctolagus cuniculus). Animals (Basel). 2016 Feb 26;6(3). pii: E19. doi: 10.3390/ani6030019. PubMed PMID: 26927192; PubMed Central PMCID: PMC4810047. 5: Maršálek P, Modrá H, Doubková V, Večerek V. Simultaneous determination of ten anticoagulant rodenticides in tissues by column-switching UHPLC-ESI-MS/MS. Anal Bioanal Chem. 2015 Oct;407(25):7849-54. doi: 10.1007/s00216-015-8954-1. Epub 2015 Aug 18. PubMed PMID: 26280206. 6: Gallocchio F, Basilicata L, Benetti C, Angeletti R, Binato G. Multi-residue determination of eleven anticoagulant rodenticides by high-performance liquid chromatography with diode array/fluorimetric detection: investigation of suspected animal poisoning in the period 2012-2013 in north-eastern Italy. Forensic Sci Int. 2014 Nov;244:63-9. doi: 10.1016/j.forsciint.2014.08.012. Epub 2014 Aug 20. PubMed PMID: 25195128. 7: Istvan SA, Marks SL, Murphy LA, Dorman DC. Evaluation of a point-of-care anticoagulant rodenticide test for dogs. J Vet Emerg Crit Care (San Antonio). 2014 Mar-Apr;24(2):168-73. doi: 10.1111/vec.12140. Epub 2014 Jan 6. PubMed PMID: 24393382. 8: Hernández AM, Bernal J, Bernal JL, Martín MT, Caminero C, Nozal MJ. Simultaneous determination of nine anticoagulant rodenticides in soil and water by LC-ESI-MS. J Sep Sci. 2013 Aug;36(16):2593-601. doi: 10.1002/jssc.201300310. Epub 2013 Jul 11. PubMed PMID: 23733735. 9: Saito S, Sakai T, Nemoto S, Matsuda R. [Determination of pindone in animal products, fishery products, and honey by LC-MS/MS]. Shokuhin Eiseigaku Zasshi. 2011;52(5):294-8. Japanese. PubMed PMID: 22200748. 10: Saito S, Nemoto S, Matsuda R. [Determination of pindone in agricultural products by LC-MS/MS]. Shokuhin Eiseigaku Zasshi. 2011;52(4):237-43. Japanese. PubMed PMID: 21873814. 11: Chen X, Cai M, Jin M. [Rapid qualitative analysis of indandione rodenticides by high-performance liquid chromatography coupled with ion trap mass spectrometry]. Wei Sheng Yan Jiu. 2010 Sep;39(5):586-90. Chinese. PubMed PMID: 21033437. 12: Vudathala D, Cummings M, Murphy L. Analysis of multiple anticoagulant rodenticides in animal blood and liver tissue using principles of QuEChERS method. J Anal Toxicol. 2010 Jun;34(5):273-9. PubMed PMID: 20529461. 13: Jin MC, Cai MQ, Chen XH. Simultaneous measurement of indandione-type rodenticides in human serum by liquid chromatography-electrospray ionization- tandem mass spectrometry. J Anal Toxicol. 2009 Jul-Aug;33(6):294-300. PubMed PMID: 19653932. 14: Jin MC, Chen XH, Ye ML, Zhu Y. Analysis of indandione anticoagulant rodenticides in animal liver by eluent generator reagent free ion chromatography coupled with electrospray mass spectrometry. J Chromatogr A. 2008 Dec 5;1213(1):77-82. doi: 10.1016/j.chroma.2008.08.100. Epub 2008 Sep 3. PubMed PMID: 18804211. 15: Marek LJ, Koskinen WC. Multiresidue analysis of seven anticoagulant rodenticides by high-performance liquid chromatography/electrospray/mass spectrometry. J Agric Food Chem. 2007 Feb 7;55(3):571-6. PubMed PMID: 17263443. 16: Robinson MH, Twigg LE, Wheeler SH, Martin GR. Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries. Comp Biochem Physiol B Biochem Mol Biol. 2005 Mar;140(3):465-73. PubMed PMID: 15694595. 17: Jolly SE, Eason CT, Frampton C, Gumbrell RC. The anticoagulant pindone causes liver damage in the brushtail possum (Trichosurus vulpecula). Aust Vet J. 1994 Jul;71(7):220. PubMed PMID: 7945103. 18: Santoro P, Parisi G, Copetti S. [Mutagenic effect of pindone on D. melanogaster]. Boll Soc Ital Biol Sper. 1993 Apr;69(4):237-41. Italian. PubMed PMID: 8129904. 19: Martin GR, Sutherland RJ, Robertson ID, Kirkpatrick WE, King DR, Hood PJ. Assessment of the potential toxicity of a poison for rabbits, pindone (2-pivalyl 1, 3 indandione), to domestic animals. Aust Vet J. 1991 Jul;68(7):241-3. Erratum in: Aust Vet J 1992 Jul;69(7):176. PubMed PMID: 1929992. 20: Mount ME, Feldman BF, Buffington T. Vitamin K and its therapeutic importance. J Am Vet Med Assoc. 1982 Jun 1;180(11):1354-6. PubMed PMID: 7096182.