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MedKoo Cat#: 597181 | Name: 8-Deazafolic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

8-Deazafolic acid is a potent inhibitor of the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice.

Chemical Structure

8-Deazafolic acid
8-Deazafolic acid
CAS#51989-25-4

Theoretical Analysis

MedKoo Cat#: 597181

Name: 8-Deazafolic acid

CAS#: 51989-25-4

Chemical Formula: C20H20N6O6

Exact Mass: 440.1444

Molecular Weight: 440.41

Elemental Analysis: C, 54.54; H, 4.58; N, 19.08; O, 21.80

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
8-Deazafolic acid; NSC 173522; NSC-173522; NSC173522;
IUPAC/Chemical Name
(4-(((2-amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl)amino)benzoyl)-L-glutamic acid
InChi Key
PEIIBFVUZRSFNO-AWEZNQCLSA-N
InChi Code
InChI=1S/C20H20N6O6/c21-20-25-13-6-5-12(23-16(13)18(30)26-20)9-22-11-3-1-10(2-4-11)17(29)24-14(19(31)32)7-8-15(27)28/h1-6,14,22H,7-9H2,(H,24,29)(H,27,28)(H,31,32)(H3,21,25,26,30)/t14-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC=C(C3=N2)NC(N)=NC3=O)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Temple C Jr, Kussner CL, Rose JD, Smithers DL, Bennett LL Jr, Montgomery JA. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glut amic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J Med Chem. 1981 Oct;24(10):1254-8. PubMed PMID: 6948961. 2: Oatis JE Jr, Hynes JB. Sycnthesis of quinazoline analogues of folic acid modified at postion 10. J Med Chem. 1977 Nov;20(11):1393-6. PubMed PMID: 915899. 3: Hynes JB, Eason DE, Garrett CM, Colvin PL Jr. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids. J Med Chem. 1977 Apr;20(4):588-91. PubMed PMID: 850245. 4: DeGraw JI, Kisliuk RL, Gaumont Y, Baugh CM. Antimicrobial activity of 8-deazafolic acid. J Med Chem. 1974 Apr;17(4):470-1. PubMed PMID: 4208536.

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