Synonym
LRH-1 Inhibitor-3; LRH-1-Inhibitor-3; LRH1 Inhibitor 3; LRH 1 Inhibitor 3;
IUPAC/Chemical Name
1-[3'-[1-[2-(4-Morpholinyl)ethyl]-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]-ethanone
InChi Key
SLRQICGVSRRRDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H25N3O2/c1-18(27)19-4-2-5-20(16-19)21-6-3-7-22(17-21)23-8-9-26(24-23)11-10-25-12-14-28-15-13-25/h2-9,16-17H,10-15H2,1H3
SMILES Code
CC(C1=CC(C2=CC=CC(C3=NN(CCN4CCOCC4)C=C3)=C2)=CC=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
375.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary. Reprod Biol Endocrinol. 2018 Mar 20;16(1):25. doi: 10.1186/s12958-018-0348-8. PubMed PMID: 29558965; PubMed Central PMCID: PMC5859637.
2: Salmenkari H, Holappa M, Forsgard RA, Korpela R, Vapaatalo H. Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice. J Physiol Pharmacol. 2017 Jun;68(3):355-362. PubMed PMID: 28820392.
3: Yang FM, Feng SJ, Lai TC, Hu MC. A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding. Biochem J. 2015 Oct 15;471(2):199-209. doi: 10.1042/BJ20150252. Epub 2015 Aug 12. PubMed PMID: 26268559.
4: Bianco S, Jangal M, Garneau D, Gévry N. LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene. 2015 Aug 20;34(34):4509-18. doi: 10.1038/onc.2014.382. Epub 2014 Dec 1. PubMed PMID: 25435372.
5: Lai WA, Yeh YT, Lee MT, Wu LS, Ke FC, Hwang JJ. Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis. J Lipid Res. 2013 Feb;54(2):365-78. doi: 10.1194/jlr.M030239. Epub 2012 Nov 28. PubMed PMID: 23197320; PubMed Central PMCID: PMC3588866.
6: Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD. Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol Endocrinol. 2010 Dec;24(12):2281-91. doi: 10.1210/me.2010-0133. Epub 2010 Oct 13. PubMed PMID: 20943815; PubMed Central PMCID: PMC2999479.
7: Guo J, Tao SX, Chen M, Shi YQ, Zhang ZQ, Li YC, Zhang XS, Hu ZY, Liu YX. Heat treatment induces liver receptor homolog-1 expression in monkey and rat sertoli cells. Endocrinology. 2007 Mar;148(3):1255-65. Epub 2006 Dec 14. PubMed PMID: 17170099.
8: Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 2002 Jan 18;277(3):1739-48. Epub 2001 Nov 8. PubMed PMID: 11705994.
