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MedKoo Cat#: 597178 | Name: Dihydroaminopterin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydroaminopterin is an aminopterin derivative.

Chemical Structure

Dihydroaminopterin
CAS#36093-88-6

Theoretical Analysis

MedKoo Cat#: 597178

Name: Dihydroaminopterin

CAS#: 36093-88-6

Chemical Formula: C19H22N8O5

Exact Mass: 442.1713

Molecular Weight: 442.43

Elemental Analysis: C, 51.58; H, 5.01; N, 25.33; O, 18.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dihydroaminopterin;
IUPAC/Chemical Name
(4-(((2,4-diamino-1,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid
InChi Key
SWIWRMRRLKUTKE-SFVWDYPZSA-N
InChi Code
InChI=1S/C19H22N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,15,22H,5-7,20H2,(H,25,30)(H,28,29)(H,31,32)(H3,21,23,26,27)/t12-,15?/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3NC(N)=NC(N)C3=N2)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Makulu DR, Fölsch E. Reduced forms of aminopterin and methotrexate in L1210 lymphoma. J Natl Cancer Inst. 1977 Jul;59(1):245-9. PubMed PMID: 875056. 2: Bühring KU, Fölsch E. Metabolism of dihydroaminopterin and the influence of aminopterin and related derivatives on the metabolism of (-)-5-formyl-tetrahydrofolic acid in Pediococcus cerevisiae. Biochim Biophys Acta. 1976 Jan 14;421(1):22-32. PubMed PMID: 1247588.