Nitrosofolic acid, a synthetic derivative of folic acid bearing a nitroso (-NO) group, has been reported to exhibit selective cytotoxicity in cancer cells due to its redox-active nature. Limited bioactivity data indicate that nitrosofolic acid can induce oxidative stress and disrupt cellular redox homeostasis, leading to apoptosis in tumor cell lines. In vitro assays demonstrated dose-dependent inhibition of proliferation in human leukemia (HL-60) and breast cancer (MCF-7) cells, with IC₅₀ values reported around 10–20 µM. Its mechanism is thought to involve interaction with thiol-containing proteins and glutathione depletion, promoting ROS accumulation.
MedKoo Cat#: 597177
Name: Nitrosofolic acid
CAS#: 29291-35-8
Chemical Formula: C19H18N8O7
Exact Mass: 470.1298
Molecular Weight: 470.40
Elemental Analysis: C, 48.51; H, 3.86; N, 23.82; O, 23.81
The following data is based on the product molecular weight 470.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
