HH-Folic acid | CAS#83704-88-5 | vitamin B9

MedKoo Cat#: 597127 | Name: HH-Folic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HH-Folic acid is a derivative of vitamin B9.

Chemical Structure

HH-Folic acid

CAS#83704-88-5

Theoretical Analysis

MedKoo Cat#: 597127

Name: HH-Folic acid

CAS#: 83704-88-5

Chemical Formula: C20H27N7O6

Exact Mass: 461.2023

Molecular Weight: 461.47

Elemental Analysis: C, 52.05; H, 5.90; N, 21.25; O, 20.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HH-Folic acid; 1',2',3',4',5',6'-Hexahydrohomofolic acid;

IUPAC/Chemical Name

((1s,4R)-4-((2-(2-amino-4-oxo-1,4-dihydropteridin-6-yl)ethyl)amino)cyclohexane-1-carbonyl)-L-glutamic acid

InChi Key

HSDLNPMYTYMYLO-LOWVWBTDSA-N

InChi Code

InChI=1S/C20H27N7O6/c21-20-26-16-15(18(31)27-20)24-12(9-23-16)7-8-22-11-3-1-10(2-4-11)17(30)25-13(19(32)33)5-6-14(28)29/h9-11,13,22H,1-8H2,(H,25,30)(H,28,29)(H,32,33)(H3,21,23,26,27,31)/t10-,11+,13-/m0/s1

SMILES Code

O=C(O)CC[C@@H](C(O)=O)NC([C@H]1CC[C@@H](NCCC2=CN=C3NC(N)=NC(C3=N2)=O)CC1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 461.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nair MG, Otis EB, Kisliuk RL, Gaumont Y. Folate analogues. 20. Synthesis and antifolate activity of 1',2',3',4',5',6'-hexahydrohomofolic acid. J Med Chem. 1983 Feb;26(2):135-40. PubMed PMID: 6827531. 2: Hoffman JM, Pietruszkiewicz AM, Habecker CN, Phillips BT, Bolhofer WA, Cragoe EJ Jr, Torchiana ML, Lumma WC Jr, Baldwin JJ. Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. J Med Chem. 1983 Feb;26(2):140-4. PubMed PMID: 6131129.