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MedKoo Cat#: 591770 | Name: Dimethyl terephthalate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethyl terephthalate is an organic compound with the formula C₆H₄(CO₂CH₃)₂. It is the diester formed from terephthalic acid and methanol. It is a white solid that melts to give a distillable colourless liquid.

Chemical Structure

Dimethyl terephthalate
CAS#120-61-6

Theoretical Analysis

MedKoo Cat#: 591770

Name: Dimethyl terephthalate

CAS#: 120-61-6

Chemical Formula: C10H10O4

Exact Mass: 194.0579

Molecular Weight: 194.19

Elemental Analysis: C, 61.85; H, 5.19; O, 32.96

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25g USD 250.00 2 Weeks
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Synonym
Dimethyl terephthalate; Dimethyl p-phthalate; Dimethyl 4-phthalate; NSC 3503; NSC3503; NSC-3503;
IUPAC/Chemical Name
1,4-Benzenedicarboxylic acid, dimethyl ester
InChi Key
WOZVHXUHUFLZGK-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10O4/c1-13-9(11)7-3-5-8(6-4-7)10(12)14-2/h3-6H,1-2H3
SMILES Code
O=C(C1=CC=C(C(OC)=O)C=C1)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Dimethyl terephthalate is an organic compound with the formula C₆H₄(CO₂CH₃)₂.
In vitro activity:
TPA and, in particular, DMT (dimethyl terephthalate) exposure during 3T3-L1 differentiation increased the cellular lipid content and induced adipogenic markers PPAR-γ, C/EBPß, FABP4, and FASN, starting from low nanomolar concentrations. Reference: Molecules. 2022 Nov 7;27(21):7645. https://pubmed.ncbi.nlm.nih.gov/36364480/
In vivo activity:
Although it is recognized that both rats and mice may not have received a dose of the test chemical sufficiently high to provide maximum test sensitivity, it is concluded that under the conditions of this bioassay, dimethyl terephthalate was not carcinogenic for F344 rats or B6C3F1 mice. Reference: Natl Cancer Inst Carcinog Tech Rep Ser. 1979;121:1-135. https://pubmed.ncbi.nlm.nih.gov/12799671/

Preparing Stock Solutions

The following data is based on the product molecular weight 194.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Molonia MS, Muscarà C, Speciale A, Salamone FL, Toscano G, Saija A, Cimino F. The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms. Molecules. 2022 Nov 7;27(21):7645. doi: 10.3390/molecules27217645. PMID: 36364480; PMCID: PMC9656719. 2. Chen YL, Mu YS, He ZJ, Pu XM, Wang DQ, Zhou M, Yang LP. New bio-based polyester with excellent spinning performance: poly(tetrahydrofuran dimethanol-co-ethylene terephthalate). RSC Adv. 2022 Oct 14;12(45):29516-29524. doi: 10.1039/d2ra04484f. PMID: 36320739; PMCID: PMC9562050. 3. National Toxicology Program. Bioassay of dimethyl terephthalate for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 1979;121:1-135. PMID: 12799671.
In vitro protocol:
1. Molonia MS, Muscarà C, Speciale A, Salamone FL, Toscano G, Saija A, Cimino F. The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms. Molecules. 2022 Nov 7;27(21):7645. doi: 10.3390/molecules27217645. PMID: 36364480; PMCID: PMC9656719. 2. Chen YL, Mu YS, He ZJ, Pu XM, Wang DQ, Zhou M, Yang LP. New bio-based polyester with excellent spinning performance: poly(tetrahydrofuran dimethanol-co-ethylene terephthalate). RSC Adv. 2022 Oct 14;12(45):29516-29524. doi: 10.1039/d2ra04484f. PMID: 36320739; PMCID: PMC9562050.
In vivo protocol:
1. National Toxicology Program. Bioassay of dimethyl terephthalate for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 1979;121:1-135. PMID: 12799671.
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