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MedKoo Cat#: 591764 | Name: Phenylacetaldehyde
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenylacetaldehyde is an organic compound used in the synthesis of fragrances and polymers.

Chemical Structure

Phenylacetaldehyde
Phenylacetaldehyde
CAS#122-78-1

Theoretical Analysis

MedKoo Cat#: 591764

Name: Phenylacetaldehyde

CAS#: 122-78-1

Chemical Formula: C8H8O

Exact Mass: 120.0575

Molecular Weight: 120.15

Elemental Analysis: C, 79.97; H, 6.71; O, 13.32

Price and Availability

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1kg USD 370.00
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Related CAS #
No Data
Synonym
Phenylacetaldehyde; NSC 406309; NSC-406309; NSC406309
IUPAC/Chemical Name
Acetaldehyde, phenyl- (8CI)
InChi Key
DTUQWGWMVIHBKE-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2
SMILES Code
O=CCC1=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Phenylacetaldehyde is an organic compound used in the synthesis of fragrances and polymers.
In vitro activity:
This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44+/CD24- and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Reference: Antioxidants (Basel). 2020 Nov 13;9(11):1119. https://pubmed.ncbi.nlm.nih.gov/33202749/
In vivo activity:
This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44+/CD24- and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Reference: Antioxidants (Basel). 2020 Nov 13;9(11):1119. https://pubmed.ncbi.nlm.nih.gov/33202749/

Preparing Stock Solutions

The following data is based on the product molecular weight 120.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Choi HS, Kim SL, Kim JH, Ko YC, Lee DS. Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal. Antioxidants (Basel). 2020 Nov 13;9(11):1119. doi: 10.3390/antiox9111119. PMID: 33202749; PMCID: PMC7697623.
In vitro protocol:
Choi HS, Kim SL, Kim JH, Ko YC, Lee DS. Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal. Antioxidants (Basel). 2020 Nov 13;9(11):1119. doi: 10.3390/antiox9111119. PMID: 33202749; PMCID: PMC7697623.
In vivo protocol:
Choi HS, Kim SL, Kim JH, Ko YC, Lee DS. Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal. Antioxidants (Basel). 2020 Nov 13;9(11):1119. doi: 10.3390/antiox9111119. PMID: 33202749; PMCID: PMC7697623.
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