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MedKoo Cat#: 563104 | Name: JP-8g

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JP-8g is an anti-cancer and anti-inflammatory agent that acts through nitric oxide synthase signaling pathways.

Chemical Structure

JP-8g
JP-8g
CAS#1356340-69-6

Theoretical Analysis

MedKoo Cat#: 563104

Name: JP-8g

CAS#: 1356340-69-6

Chemical Formula: C27H17F2N3O6

Exact Mass: 517.1085

Molecular Weight: 517.44

Elemental Analysis: C, 62.67; H, 3.31; F, 7.34; N, 8.12; O, 18.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JP-8g; JP 8g; JP8g;
IUPAC/Chemical Name
(3'R)-9-Acetyl-2,7'-difluoro-10-methyl-1'-(2-propen-1-yl)-spiro[6H,7H-[1]benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidine-7,3'-[3H]indole]-2',6,8(1'H,9H)-trione
InChi Key
WVKHBHOIOXXGLG-MHZLTWQESA-N
InChi Code
InChI=1S/C27H17F2N3O6/c1-4-10-31-21-16(6-5-7-17(21)29)27(26(31)36)19-22(15-11-14(28)8-9-18(15)37-25(19)35)38-23-20(27)24(34)32(13(3)33)12(2)30-23/h4-9,11H,1,10H2,2-3H3/t27-/m0/s1
SMILES Code
O=C([C@@]12C(C3=O)=C(C4=CC(F)=CC=C4O3)OC(N=C(C)N5C(C)=O)=C1C5=O)N(CC=C)C6=C2C=CC=C6F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun Y, Liu J, Sun T, Zhang X, Yao J, Kai M, Jiang X, Wang R. Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity. Sci Rep. 2014 Mar 14;4:4372. doi: 10.1038/srep04372. PubMed PMID: 24626153; PubMed Central PMCID: PMC3953725.

View History

ICL-SIRT078

ICL-SIRT078