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MedKoo Cat#: 591717 | Name: Chalcone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chalcone is an anti-Alzheimer agent and a aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids.

Chemical Structure

Chalcone
Chalcone
CAS#94-41-7

Theoretical Analysis

MedKoo Cat#: 591717

Name: Chalcone

CAS#: 94-41-7

Chemical Formula: C15H12O

Exact Mass: 208.0888

Molecular Weight: 208.26

Elemental Analysis: C, 86.51; H, 5.81; O, 7.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Chalcone; NSC 26612; NSC-26612; NSC26612
IUPAC/Chemical Name
2-Propen-1-one, 1,3-diphenyl-
InChi Key
DQFBYFPFKXHELB-VAWYXSNFSA-N
InChi Code
InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
SMILES Code
O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 208.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang M, Qin HL, Leng J, Zafar A, Amjad MW, Raja MAG, Hussain MA, Bukhari SNA. Synthesis and biological evaluation of new tetramethylpyrazine based chalcone derivatives as potential anti-Alzheimer agents. Chem Biol Drug Des. 2018 Jun 19. doi: 10.1111/cbdd.13355. [Epub ahead of print] PubMed PMID: 29923315. 2: Deng Y, Li C, Li H, Lu S. Identification and Characterization of Flavonoid Biosynthetic Enzyme Genes in Salvia miltiorrhiza (Lamiaceae). Molecules. 2018 Jun 16;23(6). pii: E1467. doi: 10.3390/molecules23061467. PubMed PMID: 29914175. 3: Ayati A, Oghabi Bakhshaiesh T, Moghimi S, Esmaeili R, Majidzadeh-A K, Safavi M, Firoozpour L, Emami S, Foroumadi A. Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety. Eur J Med Chem. 2018 Jun 7;155:483-491. doi: 10.1016/j.ejmech.2018.06.015. [Epub ahead of print] PubMed PMID: 29908441. 4: He Q, Liu W, Sha S, Fan S, Yu Y, Chen L, Dong M. AMPK-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells. Cancer Sci. 2018 Jun 16. doi: 10.1111/cas.13699. [Epub ahead of print] PubMed PMID: 29908094. 5: Shi Y, Liu X, Fang Y, Tian Q, Jiang H, Ma H. 2, 3-Butanediol activated disease-resistance of creeping bentgrass by inducing phytohormone and antioxidant responses. Plant Physiol Biochem. 2018 Jun 12;129:244-250. doi: 10.1016/j.plaphy.2018.06.010. [Epub ahead of print] PubMed PMID: 29906774. 6: Malbari K, Gonsalves H, Chintakrindi A, Gohil D, Joshi M, Kothari S, Srivastava S, Chowdhary A, Kanyalkar M. In search of effective H1N1 neuraminidase inhibitor by molecular docking, antiviral evaluation and membrane interaction studies using NMR. Acta Virol. 2018;62(2):179-190. doi: 10.4149/av_2018_209. PubMed PMID: 29895159. 7: Yadav P, Lal K, Kumar L, Kumar A, Kumar A, Paul AK, Kumar R. Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates. Eur J Med Chem. 2018 Jun 2;155:263-274. doi: 10.1016/j.ejmech.2018.05.055. [Epub ahead of print] PubMed PMID: 29890388. 8: Zhang X, Rakesh KP, Bukhari SNA, Balakrishna M, Manukumar HM, Qin HL. Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice. Bioorg Chem. 2018 Jun 5;80:86-93. doi: 10.1016/j.bioorg.2018.06.009. [Epub ahead of print] PubMed PMID: 29890362. 9: Shehab WS, Abdellattif MH, Mouneir SM. Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives. Chem Cent J. 2018 Jun 8;12(1):68. doi: 10.1186/s13065-018-0437-y. PubMed PMID: 29881977. 10: Montenegro I, Muñoz O, Villena J, Werner E, Mellado M, Ramírez I, Caro N, Flores S, Madrid A. Structure-Activity Relationship of Dialkoxychalcones to Combat Fish Pathogen Saprolegnia australis. Molecules. 2018 Jun 7;23(6). pii: E1377. doi: 10.3390/molecules23061377. PubMed PMID: 29875340. 11: Dammene Debbih O, Sid A, Bouchene R, Bouacida S, Mazouz W, Gherraf N. Two hydrazones derived from 1-aryl-3-(p-substituted phenyl)prop-2-en-1-one: synthesis, crystal structure, Hirshfeld surface analysis and in vitro biological properties. Acta Crystallogr C Struct Chem. 2018 Jun 1;74(Pt 6):703-714. doi: 10.1107/S2053229618006812. Epub 2018 May 22. PubMed PMID: 29870006. 12: Aslan HE, Demir Y, Özaslan MS, Türkan F, Beydemir Ş, Küfrevioğlu ÖI. The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Drug Chem Toxicol. 2018 Jun 4:1-7. doi: 10.1080/01480545.2018.1463242. [Epub ahead of print] PubMed PMID: 29860891. 13: Dong N, Liu X, Zhao T, Wang L, Li H, Zhang S, Li X, Bai X, Zhang Y, Yang B. Apoptosis-inducing effects and growth inhibitory of a novel chalcone, in human hepatic cancer cells and lung cancer cells. Biomed Pharmacother. 2018 May 29;105:195-203. doi: 10.1016/j.biopha.2018.05.126. [Epub ahead of print] PubMed PMID: 29857299. 14: Kuś PM, Okińczyc P, Jakovljević M, Jokić S, Jerković I. Development of supercritical CO(2) extraction of bioactive phytochemicals from black poplar (Populus nigra L.) buds followed by GC-MS and UHPLC-DAD-QqTOF-MS. J Pharm Biomed Anal. 2018 May 25;158:15-27. doi: 10.1016/j.jpba.2018.05.041. [Epub ahead of print] PubMed PMID: 29852355. 15: Peerzada MN, Khan P, Ahmad K, Hassan MI, Azam A. Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents. Eur J Med Chem. 2018 May 22;155:13-23. doi: 10.1016/j.ejmech.2018.05.034. [Epub ahead of print] PubMed PMID: 29852328. 16: Zainuri DA, Razak IA, Arshad S. The effect of the fused-ring substituent on anthracene chalcones: crystal structural and DFT studies of 1-(anthracen-9-yl)-3-(naphthalen-2-yl)prop-2-en-1-one and 1-(anthracen-9-yl)-3-(pyren-1-yl)prop-2-en-1-one. Acta Crystallogr E Crystallogr Commun. 2018 Apr 12;74(Pt 5):650-655. doi: 10.1107/S2056989018005467. eCollection 2018 May 1. PubMed PMID: 29850084; PubMed Central PMCID: PMC5947480. 17: Tan MY, Crouse KA, Ravoof TBSA, Jotani MM, Tiekink ERT. Bis(4-meth-oxy-chalcone 4-ethyl-thio-semi-carbazon-ato-κ(2)N(1),S)zinc(II): crystal structure and Hirshfeld surface analysis. Acta Crystallogr E Crystallogr Commun. 2018 Jan 12;74(Pt 2):151-157. doi: 10.1107/S2056989018000282. eCollection 2018 Feb 1. PubMed PMID: 29850043; PubMed Central PMCID: PMC5956326. 18: Karimi-Sales E, Jeddi S, Ebrahimi-Kalan A, Alipour MR. Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway. Iran J Basic Med Sci. 2018 Apr;21(4):359-363. doi: 10.22038/IJBMS.2018.24300.6063. PubMed PMID: 29796217; PubMed Central PMCID: PMC5960750. 19: Patil V, Patil SA, Patil R, Bugarin A, Beaman K, Patil SA. Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities. Med Chem. 2018 May 23. doi: 10.2174/1573406414666180524074648. [Epub ahead of print] PubMed PMID: 29792154. 20: Méndez L, Poeylaut-Palena AA, Mata EG. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules. 2018 May 16;23(5). pii: E1193. doi: 10.3390/molecules23051193. PubMed PMID: 29772720.