Linalool | CAS#78-70-6 | ameliorates memory loss

MedKoo Cat#: 591716 | Name: Linalool

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Linalool ameliorates memory loss and behavioral impairment induced by REM-Sleep deprivation through the Serotonergic Pathway.

Chemical Structure

Linalool

CAS#78-70-6

Theoretical Analysis

MedKoo Cat#: 591716

Name: Linalool

CAS#: 78-70-6

Chemical Formula: C10H18O

Exact Mass: 154.1358

Molecular Weight: 154.25

Elemental Analysis: C, 77.87; H, 11.76; O, 10.37

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350.00	2 Weeks

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Related CAS #

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Synonym

Linalool; AI3-00942; AI3 00942; AI300942

IUPAC/Chemical Name

(1)-3,7-Dimethyl-1,6-octadien-3-ol

InChi Key

CDOSHBSSFJOMGT-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3

SMILES Code

C=CC(O)(C)CC/C=C(C)/C

Appearance

Liquid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Linalool acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity.

In vitro activity:

Linalool significantly and reversibly suppressed the voltage-gated currents in ORCs. Linalool suppressed the voltage-gated currents not only in retinal horizontal cells and ganglion cells but also in Purkinje cells. Reference: J Neural Transm (Vienna). 2005 Feb;112(2):193-203. https://pubmed.ncbi.nlm.nih.gov/15365786/

In vivo activity:

Therefore, the effect of linalool on morphine dependence and tolerance was studied. Dependence and tolerance were induced in mice using subcutaneous morphine injections, three times a day (50, 50 and 75 mg/kg /day) for 3 days. The results showed that linalool in the induction and expression phase increased the nociception threshold. Linalool (48% and 95.6% at doses 75 and 100 mg/kg, respectively), clonidine and memantine reduced the severity of withdrawal signs in the induction and expression phases. This study indicated that linalool has a significant effect on morphine tolerance and dependence. Reference: Phytother Res. 2012 Sep;26(9):1399-404. https://pubmed.ncbi.nlm.nih.gov/22318903/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	648.29
	Water	1.6	10.37

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 154.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hosseini A, Pourheidar E, Rajabian A, Asadpour E, Hosseinzadeh H, Sadeghnia HR. Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase-3 and caspase-9 during apoptosis. Food Sci Nutr. 2022 Sep 20;11(1):249-260. doi: 10.1002/fsn3.3057. PMID: 36655091; PMCID: PMC9834854. 2. Narusuye K, Kawai F, Matsuzaki K, Miyachi E. Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells. J Neural Transm (Vienna). 2005 Feb;112(2):193-203. doi: 10.1007/s00702-004-0187-y. Epub 2004 Sep 10. PMID: 15365786. 3. Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM. Effect of linalool on morphine tolerance and dependence in mice. Phytother Res. 2012 Sep;26(9):1399-404. doi: 10.1002/ptr.3736. Epub 2012 Feb 8. PMID: 22318903. 4. Coelho VR, Gianesini J, Von Borowski R, Mazzardo-Martins L, Martins DF, Picada JN, Santos AR, Brum LF, Pereira P. (-)-Linalool, a naturally occurring monoterpene compound, impairs memory acquisition in the object recognition task, inhibitory avoidance test and habituation to a novel environment in rats. Phytomedicine. 2011 Jul 15;18(10):896-901. doi: 10.1016/j.phymed.2011.02.010. Epub 2011 Mar 21. PMID: 21420842.

In vitro protocol:

In vivo protocol:

1. Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM. Effect of linalool on morphine tolerance and dependence in mice. Phytother Res. 2012 Sep;26(9):1399-404. doi: 10.1002/ptr.3736. Epub 2012 Feb 8. PMID: 22318903. 2. Coelho VR, Gianesini J, Von Borowski R, Mazzardo-Martins L, Martins DF, Picada JN, Santos AR, Brum LF, Pereira P. (-)-Linalool, a naturally occurring monoterpene compound, impairs memory acquisition in the object recognition task, inhibitory avoidance test and habituation to a novel environment in rats. Phytomedicine. 2011 Jul 15;18(10):896-901. doi: 10.1016/j.phymed.2011.02.010. Epub 2011 Mar 21. PMID: 21420842.

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