MedKoo Cat#: 558334 | Name: Desoxycortone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desoxycortone is a steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.

Chemical Structure

Desoxycortone
Desoxycortone
CAS#64-85-7

Theoretical Analysis

MedKoo Cat#: 558334

Name: Desoxycortone

CAS#: 64-85-7

Chemical Formula: C21H30O3

Exact Mass: 330.2200

Molecular Weight: 330.47

Elemental Analysis: C, 76.33; H, 9.15; O, 14.52

Price and Availability

Size Price Availability Quantity
500mg USD 450.00 2 Weeks
1g USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Desoxycortone; Desoxycorticosterone; Deoxycorticosterone; Desoxycorticosteronum; DOC; 21-Hydroxyprogesterone; 11-Deoxycorticosterone; NSC 11319; NSC-11319; NSC11319;
IUPAC/Chemical Name
Pregn-4-ene-3,20-dione, 21-hydroxy-
InChi Key
ZESRJSPZRDMNHY-YFWFAHHUSA-N
InChi Code
InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
SMILES Code
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 330.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Woolcock AD, Ward C. Successful treatment of a cat with primary hypoadrenocorticism and severe hyponatremia with desoxycorticosterone pivalate (DOCP). Can Vet J. 2015 Nov;56(11):1158-60. PubMed PMID: 26538671; PubMed Central PMCID: PMC4608469. 2: Carr AP. How best to treat Addison's disease in dogs? Vet Rec. 2016 Jul 23;179(4):96-7. doi: 10.1136/vr.i4052. PubMed PMID: 27450847. 3: Kline S, Rooker L, Nobrega-Lee M, Guthrie A. Hypoadrenocorticism (Addison's disease) in a Hoffmann's two-toed sloth (Choloepus hoffmanni). J Zoo Wildl Med. 2015 Mar;46(1):171-4. PubMed PMID: 25831596. 4: Whoriskey ST, Bartlett SL, Baitchman E. HYPOALDOSTERONISM IN A MATSCHIE'S TREE KANGAROO (DENDROLAGUS MATSCHIEI). J Zoo Wildl Med. 2016 Jun;47(2):628-31. doi: 10.1638/2015-0193.1. PubMed PMID: 27468039. 5: REES L, KING GM. Desoxycortone acetate and ascorbic acid in the treatment of schizophrenia. J Ment Sci. 1951 Apr;97(407):376-80. PubMed PMID: 14824882. 6: Bates JA, Shott S, Schall WD. Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism. Aust Vet J. 2013 Mar;91(3):77-82; discussion 81-2. doi: 10.1111/avj.12019. PubMed PMID: 23438457. 7: Kozak J. [Influence of encortone and desoxycortone acetate on some elements of gastric juice , blood serum and urine in young people (author's transl)]. Ann Univ Mariae Curie Sklodowska Med. 1975;30:181-90. Polish. PubMed PMID: 1230074. 8: de Pádua RM, Meitinger N, de Souza Filho JD, Waibel R, Gmeiner P, Braga FC, Kreis W. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids. 2012 Nov;77(13):1373-80. doi: 10.1016/j.steroids.2012.07.016. Epub 2012 Aug 11. PubMed PMID: 22917633. 9: Hosie AM, Wilkins ME, da Silva HM, Smart TG. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature. 2006 Nov 23;444(7118):486-9. Epub 2006 Nov 15. PubMed PMID: 17108970. 10: Ratka A. Interaction of morphine and steroid hormones in the postirradiation disease in rats. Pol J Pharmacol Pharm. 1984 Jan-Feb;36(1):41-9. PubMed PMID: 6462959. 11: Biglieri EG. 17 alpha-Hydroxylase deficiency: 1963-1966. J Clin Endocrinol Metab. 1997 Jan;82(1):48-50. PubMed PMID: 8989231. 12: Morild I, Christensen JA, Mikeler E, Bohle A. Peripolar cells in the avian kidney. Virchows Arch A Pathol Anat Histopathol. 1988;412(5):471-7. PubMed PMID: 3128916. 13: Ramakrishnan L, Hess GP. Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABA(A) receptor by a neurosteroid (3alpha, 21-dihydroxy-5alpha-pregnan-20-one): transient kinetic investigations. Biochemistry. 2010 Sep 14;49(36):7892-901. doi: 10.1021/bi901241g. PubMed PMID: 20726514. 14: Bortolato M, Devoto P, Roncada P, Frau R, Flore G, Saba P, Pistritto G, Soggiu A, Pisanu S, Zappala A, Ristaldi MS, Tattoli M, Cuomo V, Marrosu F, Barbaccia ML. Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. Neuropharmacology. 2011 Jun;60(7-8):1301-8. doi: 10.1016/j.neuropharm.2011.01.013. Epub 2011 Jan 20. PubMed PMID: 21256141. 15: Reddy DS. Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Trends Pharmacol Sci. 2003 Mar;24(3):103-6. Review. PubMed PMID: 12628349. 16: DUNIHUE FW, VAN ROBERTSON WB. The effect of desoxycorticosterone acetate and of sodium on the juxtaglomerular apparatus. Endocrinology. 1957 Sep;61(3):293-9. PubMed PMID: 13461821. 17: Mendelson WB, Martin JV, Perlis M, Wagner R, Majewska MD, Paul SM. Sleep induction by an adrenal steroid in the rat. Psychopharmacology (Berl). 1987;93(2):226-9. PubMed PMID: 3122256. 18: OPLETALOVA-BECHNA J. [Use of DOCA in prematures]. Prakt Lek. 1952 May 5;32(9):209-11. Undetermined Language. PubMed PMID: 14929822. 19: Colby HD, Skelton FR, Brownie AC. Testosterone-induced hypertension in the rat. Endocrinology. 1970 May;86(5):1093-101. PubMed PMID: 4392222. 20: MENDELL HE, SKELTON JM, MOYER JH. An evaluation of pregnenolone and a combination of desoxycorticosterone acetate-sodium ascorbate in the treatment of arthritis. Am Pract Dig Treat. 1952 Oct;3(10):818-23. PubMed PMID: 12986167.