Methacetin | CAS#51-66-1 | breath test

MedKoo Cat#: 591680 | Name: Methacetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methacetin breath test for non invasive staging of liver fibrosis in patients with chronic hepatitis C.

Chemical Structure

Methacetin

CAS#51-66-1

Theoretical Analysis

MedKoo Cat#: 591680

Name: Methacetin

CAS#: 51-66-1

Chemical Formula: C9H11NO2

Exact Mass: 165.0790

Molecular Weight: 165.19

Elemental Analysis: C, 65.44; H, 6.71; N, 8.48; O, 19.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Methacetin; AI3-00798; AI3 00798; AI300798

IUPAC/Chemical Name

4'-Methoxyacetanilide

InChi Key

XVAIDCNLVLTVFM-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H11NO2/c1-7(11)10-8-3-5-9(12-2)6-4-8/h3-6H,1-2H3,(H,10,11)

SMILES Code

CC(NC1=CC=C(OC)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 165.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Haimerl M, Probst U, Poelsterl S, Beyer L, Fellner C, Selgrad M, Hornung M, Stroszczynski C, Wiggermann P. Hepatobiliary MRI: Signal intensity based assessment of liver function correlated to (13)C-Methacetin breath test. Sci Rep. 2018 Jun 13;8(1):9078. doi: 10.1038/s41598-018-27401-5. PubMed PMID: 29899400. 2: Haimerl M, Fuhrmann I, Poelsterl S, Fellner C, Nickel MD, Weigand K, Dahlke MH, Verloh N, Stroszczynski C, Wiggermann P. Gd-EOB-DTPA-enhanced T1 relaxometry for assessment of liver function determined by real-time (13)C-methacetin breath test. Eur Radiol. 2018 Mar 12. doi: 10.1007/s00330-018-5337-y. [Epub ahead of print] PubMed PMID: 29532241. 3: Bożek M, Kamińska M, Kasicka-Jonderko A, Krusiec-Świdergoł B, Ptaszek K, Juszczyk M, Jonderko K. Scrutiny of (13)C-phenylalanine breath test reproducibility. Isotopes Environ Health Stud. 2018 Jun;54(3):312-323. doi: 10.1080/10256016.2018.1431627. Epub 2018 Feb 6. PubMed PMID: 29409350. 4: Gorowska-Kowolik K, Chobot A, Kwiecien J. (13)C Methacetin Breath Test for Assessment of Microsomal Liver Function: Methodology and Clinical Application. Gastroenterol Res Pract. 2017;2017:7397840. doi: 10.1155/2017/7397840. Epub 2017 Jul 5. Review. PubMed PMID: 28757868; PubMed Central PMCID: PMC5516731. 5: Rubin TM, Heyne K, Luchterhand A, Jan Bednarsch, W R Vondran F, Polychronidis G, Malinowski M, Nikolic A, Tautenhahn HM, Jara M, Wünsch T, Stockmann M, Friso Lock J. Kinetic validation of the LiMAx test during 10 000 intravenous (13)C-methacetin breath tests. J Breath Res. 2017 Nov 29;12(1):016005. doi: 10.1088/1752-7163/aa820b. PubMed PMID: 28742055. 6: Moran S, Mina A, Duque X, Ortiz-Olvera N, Rodriguez-Leal G, Alfredo Sierra-Ramírez J, Medina-Santillán R, Mera RM, Uribe M. The utility of the (13)C-methacetin breath test in predicting the long-term survival of patients with decompensated cirrhosis. J Breath Res. 2017 Sep 7;11(3):036011. doi: 10.1088/1752-7163/aa7b99. PubMed PMID: 28649974. 7: Lock JF, Westphal T, Rubin T, Malinowski M, Schulz A, Jara M, Bednarsch J, Stockmann M. LiMAx Test Improves Diagnosis of Chemotherapy-Associated Liver Injury Before Resection of Colorectal Liver Metastases. Ann Surg Oncol. 2017 Sep;24(9):2447-2455. doi: 10.1245/s10434-017-5887-2. Epub 2017 May 17. PubMed PMID: 28516292. 8: Kolesov BA. Raman spectra of crystalline secondary amides. Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 15;179:216-220. doi: 10.1016/j.saa.2017.02.046. Epub 2017 Feb 24. PubMed PMID: 28249236. 9: Lodewick TM, Alizai PH, van Dam RM, Roeth AAJ, Schmeding M, Heidenhain C, Andert A, Gassler N, Dejong CHC, Neumann UP. Effect of Age on Liver Function in Patients Undergoing Partial Hepatectomy. Dig Surg. 2017;34(3):233-240. doi: 10.1159/000452494. Epub 2017 Feb 15. PubMed PMID: 28196354; PubMed Central PMCID: PMC5516418. 10: Stravitz RT, Ilan Y. Potential use of metabolic breath tests to assess liver disease and prognosis: has the time arrived for routine use in the clinic? Liver Int. 2017 Mar;37(3):328-336. doi: 10.1111/liv.13268. Epub 2016 Nov 19. Review. PubMed PMID: 27718326. 11: Furnari M, Ahmed I, Erpecum KJ, Savarino V, Giannini EG. Breath Tests to Assess Alcoholic Liver Disease. Rev Recent Clin Trials. 2016;11(3):185-90. Review. PubMed PMID: 27515960. 12: Kempiński R, Neubauer K, Wieczorek S, Dudkowiak R, Jasińska M, Poniewierka E. 13C-Methacetin Breath Testing in Patients with Non-Alcoholic Fatty Liver Disease. Adv Clin Exp Med. 2016 Jan-Feb;25(1):77-81. doi: 10.17219/acem/60878. PubMed PMID: 26935501. 13: Bednarsch J, Menk M, Malinowski M, Weber-Carstens S, Pratschke J, Stockmann M. (13) C Breath Tests Are Feasible in Patients With Extracorporeal Membrane Oxygenation Devices. Artif Organs. 2016 Jul;40(7):692-8. doi: 10.1111/aor.12634. Epub 2015 Nov 3. PubMed PMID: 26527580. 14: Jara M, Bednarsch J, Malinowski M, Pratschke J, Stockmann M. Effects of oxaliplatin-based chemotherapy on liver function--an analysis of impact and functional recovery using the LiMAx test. Langenbecks Arch Surg. 2016 Feb;401(1):33-41. doi: 10.1007/s00423-015-1352-5. Epub 2015 Oct 27. PubMed PMID: 26507639. 15: Stravitz RT, Reuben A, Mizrahi M, Lalazar G, Brown K, Gordon SC, Ilan Y, Sanyal A. Use of the methacetin breath test to classify the risk of cirrhotic complications and mortality in patients evaluated/listed for liver transplantation. J Hepatol. 2015 Dec;63(6):1345-51. doi: 10.1016/j.jhep.2015.07.021. Epub 2015 Jul 26. PubMed PMID: 26220750. 16: Lodewick TM, Roeth AA, Olde Damink SW, Alizai PH, van Dam RM, Gassler N, Schneider M, Dello SA, Schmeding M, Dejong CH, Neumann UP. Sarcopenia, obesity and sarcopenic obesity: effects on liver function and volume in patients scheduled for major liver resection. J Cachexia Sarcopenia Muscle. 2015 Jun;6(2):155-63. doi: 10.1002/jcsm.12018. Epub 2015 Apr 28. PubMed PMID: 26136191; PubMed Central PMCID: PMC4458081. 17: Iryna K, Helen M, Elena S. Drug-induced Liver Disease in Patients with Diabetes Mellitus. Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):83-86. doi: 10.5005/jp-journals-10018-1140. Epub 2016 Jul 9. PubMed PMID: 29201698; PubMed Central PMCID: PMC5578532. 18: Bednarsch J, Jara M, Lock JF, Malinowski M, Pratschke J, Stockmann M. Noninvasive diagnosis of chemotherapy induced liver injury by LiMAx test--two case reports and a review of the literature. BMC Res Notes. 2015 Mar 26;8:99. doi: 10.1186/s13104-015-1055-6. Review. PubMed PMID: 25889706; PubMed Central PMCID: PMC4403679. 19: Shteyer E, Nitzan I, Godfarb A, Hemed N, Revel-Vilk S. Activity of cytochrome P450 1A2 in relation to hepatic iron accumulation in transfusion-dependent β-thalassaemia major patients. Vox Sang. 2015 Apr;108(3):268-73. doi: 10.1111/vox.12223. Epub 2014 Dec 4. PubMed PMID: 25471486. 20: Hoppe S, von Loeffelholz C, Lock JF, Doecke S, Sinn BV, Rieger A, Malinowski M, Pfeiffer AF, Neuhaus P, Stockmann M. Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. J Invest Surg. 2015 Feb;28(1):24-31. doi: 10.3109/08941939.2014.971206. Epub 2014 Nov 13. PubMed PMID: 25394215.