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MedKoo Cat#: 563069 | Name: Setin-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Setin-1 is the most potent inhibitor of Set7 that acts by inhibiting the KMTase G9a.

Chemical Structure

Setin-1
Setin-1
CAS#1313802-67-3

Theoretical Analysis

MedKoo Cat#: 563069

Name: Setin-1

CAS#: 1313802-67-3

Chemical Formula: C29H21F3N2O2

Exact Mass: 486.1555

Molecular Weight: 486.49

Elemental Analysis: C, 71.60; H, 4.35; F, 11.72; N, 5.76; O, 6.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Setin-1; Setin 1; Setin1;
IUPAC/Chemical Name
3-((3-(4-(4-(trifluoromethyl)phenyl)-1H-indol-1-yl)benzyl)amino)benzoic acid
InChi Key
XPJOGIGKCTXMJB-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H21F3N2O2/c30-29(31,32)22-12-10-20(11-13-22)25-8-3-9-27-26(25)14-15-34(27)24-7-1-4-19(16-24)18-33-23-6-2-5-21(17-23)28(35)36/h1-17,33H,18H2,(H,35,36)
SMILES Code
FC(F)(F)C1=CC=C(C2=CC=CC3=C2C=CN3C4=CC(CNC5=CC(C(O)=O)=CC=C5)=CC=C4)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 486.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kashyap S, Sandler J, Peters U, Martinez EJ, Kapoor TM. Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors. Bioorg Med Chem. 2014 Apr 1;22(7):2253-60. doi: 10.1016/j.bmc.2014.02.024. Epub 2014 Feb 28. PubMed PMID: 24650704; PubMed Central PMCID: PMC4038709.