JMC-4 is a synthetic small molecule exhibiting potent anticancer activity through selective inhibition of the MDM2-p53 interaction. By binding to the MDM2 protein, JMC-4 prevents the degradation of the tumor suppressor protein p53, thereby restoring p53's ability to induce cell cycle arrest and apoptosis in cancer cells. Preclinical studies demonstrate that JMC-4 effectively reactivates p53 signaling in p53 wild-type tumor models, leading to significant antitumor effects.
MedKoo Cat#: 563068
Name: JMC-4
CAS#: 93261-39-3
Chemical Formula: C17H10N2O6
Exact Mass: 338.0539
Molecular Weight: 338.28
Elemental Analysis: C, 60.36; H, 2.98; N, 8.28; O, 28.38
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.5 | 1.48 | |
| Methanol | 0.1 | 0.30 |
The following data is based on the product molecular weight 338.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
