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MedKoo Cat#: 591642 | Name: Amyl salicylate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amyl salicylate (AS) is a fragrance massively used as a personal care product; after prolonged exposures to high AS concentration, potential immunotoxicity and changes in transcriptional regulation of pathways involved in energy metabolism, stress response, apoptosis and cell death regulations have been observed in Mytilus galloprovincialis. Conversely, exposure to low AS concentration demonstrated weak transcriptional changes and transient increased representation of opportunistic pathogens, as Arcobacter genus and Vibrio aestuarianus.

Chemical Structure

Amyl salicylate
Amyl salicylate
CAS#2050-08-0

Theoretical Analysis

MedKoo Cat#: 591642

Name: Amyl salicylate

CAS#: 2050-08-0

Chemical Formula: C12H16O3

Exact Mass: 208.1099

Molecular Weight: 208.26

Elemental Analysis: C, 69.21; H, 7.74; O, 23.05

Price and Availability

Size Price Availability Quantity
250mg USD 390.00
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Related CAS #
No Data
Synonym
Amyl salicylate; AI3-00334; AI3 00334; AI300334
IUPAC/Chemical Name
Benzoic acid, 2-hydroxy-, pentyl ester
InChi Key
RANVDUNFZBMTBK-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16O3/c1-2-3-6-9-15-12(14)10-7-4-5-8-11(10)13/h4-5,7-8,13H,2-3,6,9H2,1H3
SMILES Code
O=C(OCCCCC)C1=CC=CC=C1O
Appearance
Liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 208.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Plant Physiol Biochem. 2020 Dec;157:276-283. doi: 10.1016/j.plaphy.2020.10.026. Epub 2020 Oct 29. PMID: 33152646. 4: Vecchiato M, Cremonese S, Gregoris E, Barbaro E, Gambaro A, Barbante C. Fragrances as new contaminants in the Venice lagoon. Sci Total Environ. 2016 Oct 1;566-567:1362-1367. doi: 10.1016/j.scitotenv.2016.05.198. Epub 2016 Jun 4. PMID: 27267717. 5: Vecchiato M, Gregoris E, Barbaro E, Barbante C, Piazza R, Gambaro A. Fragrances in the seawater of Terra Nova Bay, Antarctica. Sci Total Environ. 2017 Sep 1;593-594:375-379. doi: 10.1016/j.scitotenv.2017.03.197. Epub 2017 Mar 27. PMID: 28351805. 6: Kadono M, Kubo K, Miyazaki H, Tojyo N, Nakagawa S, Miyashita K, Imanishi T, Rytting JH, Mayumi T. Enhanced in vitro percutaneous penetration of salicylate by ion pair formation with alkylamines. Biol Pharm Bull. 1998 Jun;21(6):599-603. doi: 10.1248/bpb.21.599. PMID: 9657045. 7: Nandy S, Mukherjee A, Pandey DK, Ray P, Dey A. Indian Sarsaparilla (Hemidesmus indicus): Recent progress in research on ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2020 May 23;254:112609. doi: 10.1016/j.jep.2020.112609. Epub 2020 Jan 30. PMID: 32007632. 8: Kalil DM, Silvestro LS, Austin PN. Novel preoperative pharmacologic methods of preventing postoperative sore throat due to tracheal intubation. AANA J. 2014 Jun;82(3):188-97. PMID: 25109156. 9: Picone M, Distefano GG, Marchetto D, Russo M, Vecchiato M, Gambaro A, Barbante C, Ghirardini AV. Fragrance materials (FMs) affect the larval development of the copepod Acartia tonsa: An emerging issue for marine ecosystems. Ecotoxicol Environ Saf. 2021 Jun 1;215:112146. doi: 10.1016/j.ecoenv.2021.112146. Epub 2021 Mar 18. PMID: 33744517. 10: Schnuch A, Uter W, Geier J, Lessmann H, Frosch PJ. Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature. Contact Dermatitis. 2007 Jul;57(1):1-10. doi: 10.1111/j.1600-0536.2007.01088.x. PMID: 17577350. 11: Soo Lim D, Min Choi S, Kim KB, Yoon K, Kacew S, Sik Kim H, Lee BM. Determination of fragrance allergens and their dermal sensitization quantitative risk assessment (QRA) in 107 spray perfumes. J Toxicol Environ Health A. 2018;81(22):1173-1185. doi: 10.1080/15287394.2018.1543232. Epub 2018 Nov 12. PMID: 30415634. 12: Yang L, Liu J, Wang X, Wang R, Ren F, Zhang Q, Shan Y, Ding S. Characterization of Volatile Component Changes in Jujube Fruits during Cold Storage by Using Headspace-Gas Chromatography-Ion Mobility Spectrometry. Molecules. 2019 Oct 30;24(21):3904. doi: 10.3390/molecules24213904. PMID: 31671527; PMCID: PMC6864690. 13: Barry PH, Chiu P, Lynch JW. An analysis of odorant-induced currents in on- cell patches on mammalian olfactory receptor neurons. Ann N Y Acad Sci. 1998 Nov 30;855:208-11. doi: 10.1111/j.1749-6632.1998.tb10568.x. PMID: 9929607. 14: Frosch PJ, Pilz B, Andersen KE, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Fuchs T, Hannuksela M, Lachapelle JM, et al. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis. 1995 Nov;33(5):333-42. doi: 10.1111/j.1600-0536.1995.tb02048.x. PMID: 8565489. 15: Choi HK, Song GC, Yi HS, Ryu CM. Field evaluation of the bacterial volatile derivative 3-pentanol in priming for induced resistance in pepper. J Chem Ecol. 2014 Aug;40(8):882-92. doi: 10.1007/s10886-014-0488-z. Epub 2014 Aug 23. PMID: 25149655. 16: Villa C, Gambaro R, Mariani E, Dorato S. High-performance liquid chromatographic method for the simultaneous determination of 24 fragrance allergens to study scented products. J Pharm Biomed Anal. 2007 Jul 27;44(3):755-62. doi: 10.1016/j.jpba.2007.03.020. Epub 2007 Mar 27. PMID: 17475438. 17: Guttman R. STABILIZATION OF SPIDER CRAB NERVE MEMBRANES BY ALKALINE EARTHS, AS MANIFESTED IN RESTING POTENTIAL MEASUREMENTS. J Gen Physiol. 1940 Jan 20;23(3):343-64. doi: 10.1085/jgp.23.3.343. PMID: 19873160; PMCID: PMC2237927. 18: Hajratwala BR, Hennig AJ. Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6. J Pharm Sci. 1977 Jan;66(1):107-9. doi: 10.1002/jps.2600660127. PMID: 833722. 19: Ohsuzu F, Katsushika S, Akanuma M, Nakamura H, Harada H, Satoh M, Hiroi S, Kimura A. Hypertrophic obstructive cardiomyopathy due to a novel T-to-A transition at codon 624 in the beta-myosin heavy chain (beta-MHC) gene possibly related to the sudden death. Int J Cardiol. 1997 Dec 19;62(3):203-9. doi: 10.1016/s0167-5273(97)00256-8. PMID: 9476679. 20: Gray CM, Skinner JE. Field potential response changes in the rabbit olfactory bulb accompany behavioral habituation during the repeated presentation of unreinforced odors. Exp Brain Res. 1988;73(1):189-97. doi: 10.1007/BF00279672. PMID: 3208856.

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