Azidamfenicol | CAS#13838-08-9 | antibiotic

MedKoo Cat#: 584462 | Name: Azidamfenicol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic that is active against Gram-negative and Gram-positive bacteria. It inhibits ribosomal peptidyltransferase.

Chemical Structure

Azidamfenicol

CAS#13838-08-9

Theoretical Analysis

MedKoo Cat#: 584462

Name: Azidamfenicol

CAS#: 13838-08-9

Chemical Formula: C11H13N5O5

Exact Mass: 295.0917

Molecular Weight: 295.26

Elemental Analysis: C, 44.75; H, 4.44; N, 23.72; O, 27.09

Price and Availability

Size	Price	Availability
5mg	USD 150.00	Ready to ship
10mg	USD 250.00	Ready to ship
25mg	USD 450.00	Ready to ship
50mg	USD 750.00	Ready to ship
100mg	USD 1,350.00	Ready to ship
200mg	USD 2,250.00	Ready to ship

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Related CAS #

No Data

Synonym

Bay f 4797; Bayer 52910; Bayer52910; Bayer-52910; Bay 52910; Bay52910; Bay-52910; Leukomycin N; (-)-Azidamphenicol; Azidamfenicol; Azidamphenicol;

IUPAC/Chemical Name

2-azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamide

InChi Key

SGRUZFCHLOFYHZ-MWLCHTKSSA-N

InChi Code

InChI=1S/C11H13N5O5/c12-15-13-5-10(18)14-9(6-17)11(19)7-1-3-8(4-2-7)16(20)21/h1-4,9,11,17,19H,5-6H2,(H,14,18)/t9-,11-/m1/s1

SMILES Code

O=C(N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CN=[N+]=[N-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#T21D10P16

QC Data

View QC data: current batch, Lot#T21D10P16

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic. Azidamfenicol inhibits ribosomal peptidyltransferase (Ki=22 µM).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 295.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Zhang L, Toplak M, Saleem-Batcha R, Höing L, Jakob R, Jehmlich N, von Bergen M, Maier T, Teufel R. Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol. Chembiochem. 2023 Jan 17;24(2):e202200632. doi: 10.1002/cbic.202200632. Epub 2022 Dec 5. PMID: 36353978. 2: Raulin C, Frosch PJ. Kontaktallergie auf Clotrimazol und Azidamfenicol [Contact allergy to clotrimazole and azidamfenicol]. Derm Beruf Umwelt. 1987 Mar-Apr;35(2):64-6. German. PMID: 2954808. 3: Bedair MM, Korany MA, Elsayed MA, Fahmy OT. Derivative spectrophotometric determination of clotrimazole in single formulations and in combination with other drugs. J Assoc Off Anal Chem. 1989 May-Jun;72(3):432-5. PMID: 2745365. 4: Poitschek C, Thurner J, Haller I. Bestimmung der antimikrobiellen Wirksamkeit einer Kombination aus Azidamfenicol, Clotrimazol und Dexamethason in vitro [Determination of antimicrobial activity of a combination of acidamfenicol, clotrimazole and dexamethasone in vitro (author's transl)]. Arzneimittelforschung. 1978;28(2):232-4. German. PMID: 580383. 5: Polkowska M, Urbanska Z, Wolowa F. Baycuten und Baycuten SD. Wirking und Verträglichkeit [Baycuten and baycuten SD. Effect and tolerance]. Med Welt. 1982 Apr 8;33(14):525-9. German. PMID: 7087733. 6: Polkowska M. Kliniczna ocena preparatów Baycuten i Baycuten SD firmy Bayer [Clinical evaluation of the preparations Baycuten and Baycuten SD produced by Bayer]. Przegl Dermatol. 1984 Sep-Oct;71(5):483-6. Polish. PMID: 6396736.