MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597108 | Name: Anthglutin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anthglutin is a reversible inhibitor of glutamyl transspeptidase.

Chemical Structure

Anthglutin
Anthglutin
CAS#69168-09-8

Theoretical Analysis

MedKoo Cat#: 597108

Name: Anthglutin

CAS#: 69168-09-8

Chemical Formula: C12H15N3O5

Exact Mass: 281.1012

Molecular Weight: 281.26

Elemental Analysis: C, 51.24; H, 5.38; N, 14.94; O, 28.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Anthglutin; GGCPH; gamma-Glutamyl(o-carboxy)phenylhydrazide
IUPAC/Chemical Name
(S)-2-(2-(4-amino-4-carboxybutanoyl)hydrazinyl)benzoic acid
InChi Key
MNKLHFNNZQBTRE-QMMMGPOBSA-N
InChi Code
InChI=1S/C12H15N3O5/c13-8(12(19)20)5-6-10(16)15-14-9-4-2-1-3-7(9)11(17)18/h1-4,8,14H,5-6,13H2,(H,15,16)(H,17,18)(H,19,20)/t8-/m0/s1
SMILES Code
O=C(C1=CC=CC=C1NNC(CC[C@@H](C(O)=O)N)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sweiry JH, Sastre J, Viña J, Elsässer HP, Mann GE. A role for gamma-glutamyl transpeptidase and the amino acid transport system xc- in cystine transport by a human pancreatic duct cell line. J Physiol. 1995 May 15;485 ( Pt 1):167-77. PubMed PMID: 7658371; PubMed Central PMCID: PMC1157981. 2: Cotgreave IA, Schuppe-Koistinen I. A role for gamma-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione. Biochim Biophys Acta. 1994 Jul 21;1222(3):375-82. PubMed PMID: 7913623. 3: Viña JR, Palacin M, Puertes IR, Hernandez R, Viña J. Role of the gamma-glutamyl cycle in the regulation of amino acid translocation. Am J Physiol. 1989 Dec;257(6 Pt 1):E916-22. PubMed PMID: 2575355. 4: Boogaard PJ, Mulder GJ, Nagelkerke JF. Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. II. Alpha-methylglucose uptake as a sensitive parameter for mechanistic studies of acute toxicity by xenobiotics. Toxicol Appl Pharmacol. 1989 Oct;101(1):144-57. PubMed PMID: 2799813. 5: Kera Y, Penttilä KE, Lindros KO. Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes. Biochem J. 1988 Sep 1;254(2):411-7. PubMed PMID: 2902850; PubMed Central PMCID: PMC1135093. 6: Takahashi T, Kondo T, Ohno H, Minato S, Ohshima T, Mikuni S, Soda K, Taniguchi N. A spectrophotometric method for the determination of gamma-glutamyl cyclotransferase with alanine dehydrogenase in the presence of anthglutin. Biochem Med Metab Biol. 1987 Dec;38(3):311-6. PubMed PMID: 2893631. 7: Ahmad S, Okine L, Wood R, Aljian J, Vistica DT. gamma-Glutamyl transpeptidase (gamma-GT) and maintenance of thiol pools in tumor cells resistant to alkylating agents. J Cell Physiol. 1987 May;131(2):240-6. PubMed PMID: 2884224. 8: Jones TW, Wallin A, Thor H, Gerdes RG, Ormstad K, Orrenius S. The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells. Arch Biochem Biophys. 1986 Dec;251(2):504-13. PubMed PMID: 3800381. 9: Ross D, Moldeus P, Sies H, Smith MT. Mechanism and relevance of glutathione mutagenicity. Mutat Res. 1986 Nov;175(3):127-31. PubMed PMID: 2877394. 10: Toth B. Carcinogenesis by N2-[gamma-L(+)-glutamyl]-4-carboxyphenylhydrazine of Agaricus bisporus in mice. Anticancer Res. 1986 Sep-Oct;6(5):917-20. PubMed PMID: 3800334. 11: Kera Y, Komura S, Kiriyama T, Inoue K. Effects of gamma-glutamyltranspeptidase inhibitor and reduced glutathione on renal acetaldehyde levels in rats. Biochem Pharmacol. 1985 Oct 15;34(20):3781-3. PubMed PMID: 2864930. 12: Prusak E, Szewczuk A. Purification of gamma-glutamyltransferases by immunoaffinity chromatography and some properties of the enzymes. Arch Immunol Ther Exp (Warsz). 1985;33(5):715-26. PubMed PMID: 2871822. 13: Berggren M, Dawson J, Moldéus P. Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione. FEBS Lett. 1984 Oct 15;176(1):189-92. PubMed PMID: 6149151. 14: Viña J, Puertes IR, Montoro JB, Viña JR. Effect of specific inhibition of gamma-glutamyl transpeptidase on amino acid uptake by mammary gland of the lactating rat. FEBS Lett. 1983 Aug 8;159(1-2):119-22. PubMed PMID: 6135627. 15: Selvaraj P, Balasubramanian KA. Soluble forms of gamma-glutamyltransferase in human adult liver, fetal liver, and primary hepatoma compared. Clin Chem. 1983 Jan;29(1):90-5. PubMed PMID: 6129078. 16: Ormstad K, Uehara N, Orrenius S, Orning L, Hammarström S. Uptake and metabolism of leukotriene C3 by isolated rat organs and cells. Biochem Biophys Res Commun. 1982 Feb 26;104(4):1434-40. PubMed PMID: 6122451. 17: Szewczuk A, Milnerowicz H, Prusak E, Albert Z. Light form of Morris hepatoma gamma-glutamyltransferase. Folia Histochem Cytochem (Krakow). 1982;20(1-2):25-33. PubMed PMID: 6183174. 18: Komai T, Ikeda T, Kawai K, Kameyama E, Shindo H. In vitro studies on the metabolic pathway of SQ 14225 (Captopril) and mechanism of mixed disulfide formation. J Pharmacobiodyn. 1981 Sep;4(9):677-84. PubMed PMID: 7038090. 19: Milnerowicz H, Prusak E, Siewiński M, Ziomek E, Kustrzeba-Wójcicka I, Szewczuk A. Molecular forms of bovine gamma-glutamyltransferase and their enzyme immunoassay. Arch Immunol Ther Exp (Warsz). 1981;29(5):543-9. PubMed PMID: 6127063. 20: Selvaraj P, Balasubramanian KA, Hill PG. Isolation of gamma-glutamyl transpeptidase from human primary hepatoma and comparison of its kinetic and catalytic properties with the enzyme from normal adult and fetal liver. Enzyme. 1981;26(2):57-63. PubMed PMID: 6113139.