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MedKoo Cat#: 558202 | Name: Kefton-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kefton-2 is bioactive chemical.

Chemical Structure

Kefton-2
Kefton-2
CAS#6041-00-5

Theoretical Analysis

MedKoo Cat#: 558202

Name: Kefton-2

CAS#: 6041-00-5

Chemical Formula: C31H40O2

Exact Mass: 444.3000

Molecular Weight: 444.66

Elemental Analysis: C, 83.74; H, 9.07; O, 7.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Kefton2; Kefton-2; Kefton 2;
IUPAC/Chemical Name
1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-
InChi Key
DKHGMERMDICWDU-GHDNBGIDSA-N
InChi Code
InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+
SMILES Code
O=C1C(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)C(C2=C1C=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi. J Lipid Res. 2016 Jul;57(7):1286-99. doi: 10.1194/jlr.M068759. Epub 2016 Apr 27. Erratum in: J Lipid Res. 2016 Aug;57(8):1599. PubMed PMID: 27121042; PubMed Central PMCID: PMC4918857. 9: Guralp O, Erel CT. Effects of vitamin K in postmenopausal women: mini review. Maturitas. 2014 Mar;77(3):294-9. doi: 10.1016/j.maturitas.2013.11.002. Epub 2013 Nov 27. Review. PubMed PMID: 24342502. 10: Gentili A, Cafolla A, Gasperi T, Bellante S, Caretti F, Curini R, Fernández VP. Rapid, high performance method for the determination of vitamin K(1), menaquinone-4 and vitamin K(1) 2,3-epoxide in human serum and plasma using liquid chromatography-hybrid quadrupole linear ion trap mass spectrometry. J Chromatogr A. 2014 Apr 18;1338:102-10. doi: 10.1016/j.chroma.2014.02.065. Epub 2014 Feb 28. PubMed PMID: 24630057. 11: Tsugawa N. [Clinical Pharmacokinetics of Active Vitamin D3 and its derivatives, and Vitamin K2(Menatetrenone).]. Clin Calcium. 2016;26(11):1547-1558. Japanese. PubMed PMID: 27777388. 12: Ferland G. Vitamin K and brain function. Semin Thromb Hemost. 2013 Nov;39(8):849-55. doi: 10.1055/s-0033-1357481. Epub 2013 Oct 9. Review. PubMed PMID: 24108469. 13: Iwamoto J, Sato Y. Menatetrenone for the treatment of osteoporosis. Expert Opin Pharmacother. 2013 Mar;14(4):449-58. doi: 10.1517/14656566.2013.763796. Epub 2013 Jan 25. Review. PubMed PMID: 23346882. 14: Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12;11:93. doi: 10.1186/1475-2891-11-93. PubMed PMID: 23140417; PubMed Central PMCID: PMC3502319. 15: Iwamoto J, Seki A, Sato Y, Matsumoto H. Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency. Calcif Tissue Int. 2012 Jan;90(1):50-9. doi: 10.1007/s00223-011-9548-3. Epub 2011 Nov 13. PubMed PMID: 22080166. 16: Hirai K, Yamada Y, Hayashi H, Tanaka M, Izumiya K, Suzuki M, Yoshizawa M, Moriwaki H, Akimoto T, Tsuji D, Inoue K, Itoh K. Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy. Thromb Res. 2015 May;135(5):861-6. doi: 10.1016/j.thromres.2015.02.019. Epub 2015 Feb 27. PubMed PMID: 25747538. 17: Wu WJ, Kim MS, Ahn BY. The inhibitory effect of vitamin K on RANKL-induced osteoclast differentiation and bone resorption. Food Funct. 2015 Oct;6(10):3351-8. doi: 10.1039/c5fo00544b. PubMed PMID: 26267519. 18: Kiely M, Hodgins SJ, Merrigan BA, Tormey S, Kiely PA, O'Connor EM. Real-time cell analysis of the inhibitory effect of vitamin K2 on adhesion and proliferation of breast cancer cells. Nutr Res. 2015 Aug;35(8):736-43. doi: 10.1016/j.nutres.2015.05.014. Epub 2015 May 30. PubMed PMID: 26082424. 19: McCabe KM, Booth SL, Fu X, Shobeiri N, Pang JJ, Adams MA, Holden RM. Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. Kidney Int. 2013 May;83(5):835-44. doi: 10.1038/ki.2012.477. Epub 2013 Jan 23. PubMed PMID: 23344475. 20: Wyskida K, Żak-Gołąb A, Łabuzek K, Suchy D, Ficek R, Pośpiech K, Olszanecka-Glinianowicz M, Okopień B, Więcek A, Chudek J. Daily intake and serum concentration of menaquinone-4 (MK-4) in haemodialysis patients with chronic kidney disease. Clin Biochem. 2015 Dec;48(18):1246-51. doi: 10.1016/j.clinbiochem.2015.08.011. Epub 2015 Aug 15. PubMed PMID: 26282719.

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