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MedKoo Cat#: 558201 | Name: Keenamide A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Keenamide A is a cytotoxic cyclic hexapeptide and exhibits significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.

Chemical Structure

Keenamide A
Keenamide A
CAS#177742-52-8

Theoretical Analysis

MedKoo Cat#: 558201

Name: Keenamide A

CAS#: 177742-52-8

Chemical Formula: C30H48N6O6S

Exact Mass: 620.3400

Molecular Weight: 620.81

Elemental Analysis: C, 58.04; H, 7.79; N, 13.54; O, 15.46; S, 5.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Keenamide A;
IUPAC/Chemical Name
(2S,3S)-1-((2R,3S)-2,3-diamino-2-((2S,3R)-4-(4,5-dihydrothiazol-2-yl)-3-methyl-4-oxobutan-2-yl)-5-methylhexanoyl)-3-(2-iminoacetyl)-2-(O-(2-methylbut-3-en-2-yl)-L-seryl)pyrrolidine-2-carbaldehyde
InChi Key
ZPUJRWJSNBAKEH-YDCOKLBLSA-N
InChi Code
InChI=1S/C30H48N6O6S/c1-8-28(6,7)42-15-21(32)25(40)29(16-37)20(22(38)14-31)9-11-36(29)27(41)30(34,23(33)13-17(2)3)19(5)18(4)24(39)26-35-10-12-43-26/h8,14,16-21,23,31H,1,9-13,15,32-34H2,2-7H3/t18-,19+,20-,21+,23+,29-,30-/m1/s1
SMILES Code
N=CC([C@H]1CCN(C([C@@]([C@@H](C)[C@H](C(C2=NCCS2)=O)C)([C@@H](N)CC(C)C)N)=O)[C@]1(C([C@H](COC(C)(C)C=C)N)=O)C=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 620.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wesson KJ, Hamann MT. Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii. J Nat Prod. 1996 Jun;59(6):629-31. PubMed PMID: 8786369. 2: Donia MS, Wang B, Dunbar DC, Desai PV, Patny A, Avery M, Hamann MT. Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle. J Nat Prod. 2008 Jun;71(6):941-5. doi: 10.1021/np700718p. Epub 2008 Jun 11. PubMed PMID: 18543965; PubMed Central PMCID: PMC2651694.