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MedKoo Cat#: 591594 | Name: Diphenyl phthalate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diphenyl phthalate is a biochemical.

Chemical Structure

Diphenyl phthalate
Diphenyl phthalate
CAS#84-62-8

Theoretical Analysis

MedKoo Cat#: 591594

Name: Diphenyl phthalate

CAS#: 84-62-8

Chemical Formula: C20H14O4

Exact Mass: 318.0892

Molecular Weight: 318.33

Elemental Analysis: C, 75.46; H, 4.43; O, 20.10

Price and Availability

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25g USD 250.00 2 weeks
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Synonym
Diphenyl phthalate; Phenyl phthalate; Phthalic Acid Diphenyl Ester; NSC 4052; NSC-4052; NSC4052
IUPAC/Chemical Name
1,2-Benzenedicarboxylic acid, diphenyl ester
InChi Key
DWNAQMUDCDVSLT-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14O4/c21-19(23-15-9-3-1-4-10-15)17-13-7-8-14-18(17)20(22)24-16-11-5-2-6-12-16/h1-14H
SMILES Code
O=C(C1=CC=CC=C1C(OC2=CC=CC=C2)=O)OC3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Diphenyl phthalate is a biochemical.
In vitro activity:
The increased expression of estrogen-responsive genes (TFF1, CTSD, and GREB1) was also observed in MCF-7 cells treated with DPhP. The result of molecular docking showed that DPhP tended to bind to the agonist conformation of ER compared with the antagonist conformation of ER, demonstrating its agonist characteristic that has been confirmed in the reporter gene assay. Thus, this study found that DPhP may be evaluated as an ER agonist in vitro and it can interfere with the normal function of human ER. Reference: Toxicol Mech Methods. 2022 May;32(4):280-287. https://pubmed.ncbi.nlm.nih.gov/34697989/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 318.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lv C, Wei Z, Yue B, Xia N, Huang W, Yue Y, Li Z, Li T, Zhang X, Wang Y. Characterization of diphenyl phthalate as an agonist for estrogen receptor: an in vitro and in silico study. Toxicol Mech Methods. 2022 May;32(4):280-287. doi: 10.1080/15376516.2021.1998276. Epub 2021 Nov 14. PMID: 34697989.
In vitro protocol:
1. Lv C, Wei Z, Yue B, Xia N, Huang W, Yue Y, Li Z, Li T, Zhang X, Wang Y. Characterization of diphenyl phthalate as an agonist for estrogen receptor: an in vitro and in silico study. Toxicol Mech Methods. 2022 May;32(4):280-287. doi: 10.1080/15376516.2021.1998276. Epub 2021 Nov 14. PMID: 34697989.
In vivo protocol:
TBD
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Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2years of age- CHECK cohort study. Sci Total Environ. 2018 May 15;624:377-384. doi: 10.1016/j.scitotenv.2017.12.058. Epub 2017 Dec 16. PubMed PMID: 29258038. 11: He MJ, Yang T, Yang ZH, Zhou H, Wei SQ. Current State, Distribution, and Sources of Phthalate Esters and Organophosphate Esters in Soils of the Three Gorges Reservoir Region, China. Arch Environ Contam Toxicol. 2018 Apr;74(3):502-513. doi: 10.1007/s00244-017-0469-7. Epub 2017 Oct 20. PubMed PMID: 29058061. 12: Gerona RR, Schwartz JM, Pan J, Friesen MM, Lin T, Woodruff TJ. Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry. J Expo Sci Environ Epidemiol. 2018 Mar;28(2):101-108. doi: 10.1038/jes.2017.28. Epub 2017 Oct 11. 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