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MedKoo Cat#: 563053 | Name: 7CKA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

7CKA is a NMDA receptor antagonist that acts at the glycine site.

Chemical Structure

7CKA
7CKA
CAS#18000-24-3

Theoretical Analysis

MedKoo Cat#: 563053

Name: 7CKA

CAS#: 18000-24-3

Chemical Formula: C10H6ClNO3

Exact Mass: 223.0036

Molecular Weight: 223.61

Elemental Analysis: C, 53.71; H, 2.70; Cl, 15.85; N, 6.26; O, 21.46

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
250mg USD 850.00 2 Weeks
500mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
7CKA; 7-CKA; 7 CKA; 7-CTKA; 7CTKA; 7 CTKA; 7-chloro KYNA; 7 chloro KYNA; NSC 149792; NSC149792; NSC-149792; 7-Chlorokynurenic Acid; 7 Chlorokynurenic Acid;
IUPAC/Chemical Name
7-Chloro-4-hydroxyquinoline-2-carboxylic acid
InChi Key
UAWVRVFHMOSAPU-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
SMILES Code
O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 223.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu BB, Luo L, Liu XL, Geng D, Liu Q, Yi LT. 7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress. Psychopharmacology (Berl). 2015 Feb;232(3):541-50. doi: 10.1007/s00213-014-3690-3. Epub 2014 Jul 18. PMID: 25034119. 2: Iwasaki M, Kashiwaguma Y, Nagashima C, Izumi M, Uekusa A, Iwasa S, Onozato M, Ichiba H, Fukushima T. A high-performance liquid chromatography assay with a triazole-bonded column for evaluation of d-amino acid oxidase activity. Biomed Chromatogr. 2016 Mar;30(3):384-9. doi: 10.1002/bmc.3559. Epub 2015 Aug 27. PMID: 26174062. 3: Li CF, Chen XM, Chen SM, Mu RH, Liu BB, Luo L, Liu XL, Geng D, Liu Q, Yi LT. Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid. Brain Res. 2016 Jan 1;1630:73-82. doi: 10.1016/j.brainres.2015.11.005. Epub 2015 Nov 10. PMID: 26562663. 4: Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF. Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Mol Pharmacol. 2016 Feb;89(2):253-62. doi: 10.1124/mol.115.100909. Epub 2015 Dec 10. PMID: 26661043; PMCID: PMC4746485. 5: Lin H, Jacobi AA, Anderson SA, Lynch DR. D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability. Front Cell Neurosci. 2016 Feb 25;10:34. doi: 10.3389/fncel.2016.00034. PMID: 26941605; PMCID: PMC4766304. 6: Yaksh TL, Schwarcz R, Snodgrass HR. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196. doi: 10.1016/j.jpain.2017.03.014. Epub 2017 Apr 18. PMID: 28428091. 7: Burada AP, Vinnakota R, Kumar J. Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat Struct Mol Biol. 2020 Jan;27(1):84-91. doi: 10.1038/s41594-019-0359-y. Epub 2020 Jan 10. PMID: 31925409; PMCID: PMC7025878. 8: Park LT, Kadriu B, Gould TD, Zanos P, Greenstein D, Evans JW, Yuan P, Farmer CA, Oppenheimer M, George JM, Adeojo LW, Snodgrass HR, Smith MA, Henter ID, Machado-Vieira R, Mannes AJ, Zarate CA. A Randomized Trial of the N-Methyl-d- Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression. Int J Neuropsychopharmacol. 2020 Jul 29;23(7):417-425. doi: 10.1093/ijnp/pyaa025. PMID: 32236521; PMCID: PMC7387765. 9: Burada AP, Vinnakota R, Kumar J. The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. J Struct Biol. 2020 Aug 1;211(2):107546. doi: 10.1016/j.jsb.2020.107546. Epub 2020 Jun 5. PMID: 32512155. 10: Hsieh CP, Chen H, Chan MH, Chen L, Chen HH. N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice. Toxicology. 2020 Dec 15;446:152613. doi: 10.1016/j.tox.2020.152613. Epub 2020 Oct 18. PMID: 33086094. 11: Patel W, Rimmer L, Smith M, Moss L, Smith MA, Snodgrass HR, Pirmohamed M, Alfirevic A, Dickens D. Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. Mol Pharm. 2021 Jan 4;18(1):113-123. doi: 10.1021/acs.molpharmaceut.0c00727. Epub 2020 Dec 13. PMID: 33307708. 12: Murphy N, Ramakrishnan N, Vo-Le B, Vo-Le B, Smith MA, Iqbal T, Swann AC, Mathew SJ, Lijffijt M. A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans. Neuropsychopharmacology. 2021 Mar;46(4):820-827. doi: 10.1038/s41386-020-00917-z. Epub 2020 Dec 14. PMID: 33318635.