Synonym
Ephenamine penicilline; l-Ephenamine penicillin G; Compenamine;
IUPAC/Chemical Name
2-(methylamino)-1,2-diphenylethan-1-ol (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
InChi Key
XQBNHSTXTGKXIL-LQDWTQKMSA-N
InChi Code
InChI=1S/C16H18N2O4S.C15H17NO/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-16-14(12-8-4-2-5-9-12)15(17)13-10-6-3-7-11-13/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);2-11,14-17H,1H3/t11-,12+,14-;/m1./s1
SMILES Code
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O.OC(C4=CC=CC=C4)C(NC)C5=CC=CC=C5
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
561.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mandal A, Kundu TS, Sengupta P, Ghosh A, Das N. Is This a Drug?" Answers From Medical Students in a Tertiary Care Teaching Hospital in Eastern India. J Clin Diagn Res. 2016 Aug;10(8):FC10-3. doi: 10.7860/JCDR/2016/19557.8335. Epub 2016 Aug 1. PubMed PMID: 27656461; PubMed Central PMCID: PMC5028524.
2: Post JJ, Khor C, Furner V, Smith DE, Whybin LR, Robertson PW. Case report and evaluation of the frequency of the prozone phenomenon in syphilis serology - an infrequent but important laboratory phenomenon. Sex Health. 2012 Nov;9(5):488-90. doi: 10.1071/SH11156. PubMed PMID: 22958508.
3: Pérez-Saad H, Buznego MT. Behavioral and antiepileptic effects of acute administration of the extract of the plant Cestrum nocturnum Lin (lady of the night). Epilepsy Behav. 2008 Apr;12(3):366-72. doi: 10.1016/j.yebeh.2007.12.012. Epub 2008 Feb 13. PubMed PMID: 18276193.
4: Buznego MT, Pérez-Saad H. Behavioral and antiepileptic effect of acute administration of the extract of the aquatic plant Echinodorus berteroi (Sprengel) Fassett (upright burhead). Epilepsy Behav. 2006 Aug;9(1):40-5. Epub 2006 May 18. PubMed PMID: 16713362.
5: García Callejo FJ, Velert Vila MM, Costa I, Urchueguía MT. [Unusual analytical interference caused by benzathine penicillin G]. Acta Otorrinolaringol Esp. 1998 Nov-Dec;49(8):671-2. Spanish. PubMed PMID: 9951093.
6: Culić M, Saponjić J, Janković B, Rakić L. Amphetamine and haloperidol modulatory effects on Purkinje cell activity and on EEG power spectra in the acute rat model of epilepsy. Neurosci Lett. 1994 Dec 5;182(2):259-62. PubMed PMID: 7715822.
7: Culić M, Saponjić J, Janković B, Rakić LJ. Activity of cat cerebellar neurons in penicillin epilepsy and amphetamine treatment. Arch Ital Biol. 1992 Jul;130(3):167-77. PubMed PMID: 1510548.
8: Dunnick JK, Elwell MR. Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, alpha-methyldopa, penicillin VK and propantheline bromide in rats and mice. Toxicology. 1989 Jun 1;56(2):123-36. PubMed PMID: 2499954.
9: Mukherjee DK, Mukherjee K. Ototoxicity of commonly used pharmaceutical preparations. Niger Med J. 1979 Jan;9(1):52-7. PubMed PMID: 463341.
10: Cohen SN, Cohen JL. Pharmacotherapeutics. Review and commentary. Pediatr Clin North Am. 1974 Feb;21(1):95-101. PubMed PMID: 4811131.
11: Gurin VN. [The effect of neuromediators on soluble thiol levels in brain tissue]. Biull Eksp Biol Med. 1973 Apr;75(4):42-4. Russian. PubMed PMID: 4374979.
12: Mukherjee D. Studies on the effect of free fatty acid on binding of benzyl-penicillin by serum proteins. J Antibiot (Tokyo). 1970 Jul;23(7):348-53. PubMed PMID: 5460276.
13: Mitchell DF. Undesirable side reactions to drugs. Dent Clin North Am. 1968 Mar:257-60. PubMed PMID: 5237366.
14: REED CF, WITT PN, PEAKALL DB. FREE-HAND COPYING OF A GEOMETRIC PATTERN AS A TEST FOR SENSORY-MOTOR DISTURBANCE. Percept Mot Skills. 1965 Jun;20:941-51. PubMed PMID: 14314018.
