MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 563042 | Name: QS11
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARF-GAP1) inhibitor.

Chemical Structure

QS11
QS11
CAS#944328-88-5

Theoretical Analysis

MedKoo Cat#: 563042

Name: QS11

CAS#: 944328-88-5

Chemical Formula: C36H33N5O2

Exact Mass: 567.2634

Molecular Weight: 567.69

Elemental Analysis: C, 76.17; H, 5.86; N, 12.34; O, 5.64

Price and Availability

Size Price Availability Quantity
5mg USD 290.00
10mg USD 480.00
25mg USD 890.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
QS11; QS-11; QS 11;
IUPAC/Chemical Name
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol
InChi Key
DOKZLKDGUQWMSX-HKBQPEDESA-N
InChi Code
InChI=1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1
SMILES Code
OC[C@@H](NC1=C2N=CN(CC3=CC=C(C4=CC=CC=C4)C=C3)C2=NC(OC5=CC6=C(CCC6)C=C5)=N1)CC7=CC=CC=C7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 567.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qian J, Li Y, Yao H, Tian H, Wang H, Ai L, Xie Y, Bao Y, Liang L, Hu Y, Zhang Y, Wang J, Li C, Tang J, Chen Y, Xu J, Fang JY. ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. Signal Transduct Target Ther. 2017 Feb 24;2:17003. doi: 10.1038/sigtrans.2017.3. eCollection 2017. PubMed PMID: 29263912; PubMed Central PMCID: PMC5661632. 2: Knight A, Littlejohns P, Poole TL, Leng G, Drummond C. The NICE alcohol misuse standard - evaluating its impact. Int J Health Care Qual Assur. 2017 Apr 18;30(3):260-273. doi: 10.1108/IJHCQA-03-2016-0025. PubMed PMID: 28350221. 3: Yamauchi Y, Miura Y, Kanaho Y. Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs. Adv Biol Regul. 2017 Jan;63:115-121. doi: 10.1016/j.jbior.2016.10.004. Epub 2016 Oct 18. Review. PubMed PMID: 27776975. 4: Wu J, Li W, Lin C, Chen Y, Cheng C, Sun S, Tang M, Chai R, Li H. Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. Sci Rep. 2016 Jul 20;6:29418. doi: 10.1038/srep29418. PubMed PMID: 27435629; PubMed Central PMCID: PMC4951696. 5: Pauloin A, Adenot P, Hue-Beauvais C, Chanat E. The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells. Cell Biol Int. 2016 Feb;40(2):143-55. doi: 10.1002/cbin.10547. Epub 2015 Sep 30. PubMed PMID: 26399370. 6: Singh MK, Gao H, Sun W, Song Z, Schmalzigaug R, Premont RT, Zhang Q. Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4838-4842. doi: 10.1016/j.bmcl.2015.06.062. Epub 2015 Jun 23. PubMed PMID: 26152429; PubMed Central PMCID: PMC4607626. 7: Huang N, Chen D, Wu X, Chen X, Zhang X, Niu J, Shen HY, Xiao L. Aspirin Promotes Oligodendroglial Differentiation Through Inhibition of Wnt Signaling Pathway. Mol Neurobiol. 2016 Jul;53(5):3258-3266. doi: 10.1007/s12035-015-9241-z. Epub 2015 Jun 10. PubMed PMID: 26059811. 8: Ivanyuk D, Budash G, Zheng Y, Gaspar JA, Chaudhari U, Fatima A, Bahmanpour S, Grin VK, Popandopulo AG, Sachinidis A, Hescheler J, Šarić T. Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway. Cell Physiol Biochem. 2015;36(2):810-30. doi: 10.1159/000430140. Epub 2015 May 22. PubMed PMID: 26021268. 9: Davies JC, Tamaddon-Jahromi S, Jannoo R, Kanamarlapudi V. Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2. Biochem Pharmacol. 2014 Dec 15;92(4):651-60. doi: 10.1016/j.bcp.2014.09.023. Epub 2014 Oct 20. PubMed PMID: 25450674. 10: Davies JC, Bain SC, Kanamarlapudi V. ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes. Biochem Pharmacol. 2014 Aug 15;90(4):406-13. doi: 10.1016/j.bcp.2014.06.012. Epub 2014 Jun 20. PubMed PMID: 24955982. 11: Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li DY. Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature. 2012 Dec 13;492(7428):252-5. doi: 10.1038/nature11603. Epub 2012 Nov 11. PubMed PMID: 23143332; PubMed Central PMCID: PMC3521847. 12: Kim W, Kim SY, Kim T, Kim M, Bae DJ, Choi HI, Kim IS, Jho E. ADP-ribosylation factors 1 and 6 regulate Wnt/β-catenin signaling via control of LRP6 phosphorylation. Oncogene. 2013 Jul 11;32(28):3390-6. doi: 10.1038/onc.2012.373. Epub 2012 Aug 20. PubMed PMID: 22907437. 13: Kanamarlapudi V, Thompson A, Kelly E, López Bernal A. ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling. J Biol Chem. 2012 Jun 8;287(24):20443-55. doi: 10.1074/jbc.M112.362087. Epub 2012 Apr 20. PubMed PMID: 22523074; PubMed Central PMCID: PMC3370224. 14: Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. Epub 2007 Apr 25. Erratum in: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12581. Jian, Xiaoying [added]; Randazzo, Paul A [added]. PubMed PMID: 17460038; PubMed Central PMCID: PMC1863490. 15: Shen Q, Bazarov I, Thibault P. Diffractive imaging of nonperiodic materials with future coherent X-ray sources. J Synchrotron Radiat. 2004 Sep 1;11(Pt 5):432-8. Epub 2004 Aug 17. PubMed PMID: 15310961. 16: Shen Q, Wang J, Ealick SE. Anomalous difference signal in protein crystals. Acta Crystallogr A. 2003 Jul;59(Pt 4):371-3. Epub 2003 Jun 26. PubMed PMID: 12832817. 17: Shen Q. Improving triplet-phase accuracy by symmetry observations in reference-beam diffraction measurements. Acta Crystallogr A. 2003 Jul;59(Pt 4):335-40. Epub 2003 Jun 26. PubMed PMID: 12832812. 18: Shen Q, Wang J. Recursive direct phasing with reference-beam diffraction. Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):809-14. Epub 2003 Apr 25. PubMed PMID: 12777795. 19: Shen Q, Kycia S, Dobrianov I. Triplet-phase measurements using reference-beam X-ray diffraction. Acta Crystallogr A. 2000 May;56 ( Pt 3):268-79. PubMed PMID: 10851590. 20: Shen Q, Kycia S, Dobrianov I. Enantiomorph determination using inverse reference-beam diffraction images. Acta Crystallogr A. 2000 May;56 ( Pt 3):264-7. PubMed PMID: 10851589.