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MedKoo Cat#: 563041 | Name: DORA 42

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DORA 42 is a dual orexin receptor antagonist (OX1R and OX2R antagonist or DORA).

Chemical Structure

DORA 42
DORA 42
CAS#1030377-48-0

Theoretical Analysis

MedKoo Cat#: 563041

Name: DORA 42

CAS#: 1030377-48-0

Chemical Formula: C22H24N8OS

Exact Mass: 448.1794

Molecular Weight: 448.54

Elemental Analysis: C, 58.91; H, 5.39; N, 24.98; O, 3.57; S, 7.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DORA 42; DORA-42; DORA42;
IUPAC/Chemical Name
[(7R)-4-(4-Amino-5-methylthieno[2,3-d]pyrimidin-2-yl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]-methanone
InChi Key
LSRYXWRLTUFERQ-OAHLLOKOSA-N
InChi Code
InChI=1S/C22H24N8OS/c1-14-13-32-20-18(14)19(23)26-22(27-20)28-10-7-15(2)29(12-11-28)21(31)16-5-3-4-6-17(16)30-24-8-9-25-30/h3-6,8-9,13,15H,7,10-12H2,1-2H3,(H2,23,26,27)/t15-/m1/s1
SMILES Code
O=C(N1CCN(C2=NC(N)=C(C(C)=CS3)C3=N2)CC[C@H]1C)C4=CC=CC=C4N5N=CC=N5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Madanchi M, Fagagnini S, Fournier N, Biedermann L, Zeitz J, Battegay E, Zimmerli L, Vavricka SR, Rogler G, Scharl M; Swiss IBD Cohort Study Group . The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort. Inflamm Bowel Dis. 2018 Apr 13. doi: 10.1093/ibd/izy054. [Epub ahead of print] PubMed PMID: 29669023. 2: Weber Pasa M, Selbach Scheffel R, Borsatto Zanella A, Maia AL, Dora JM. Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome. Eur Thyroid J. 2017 Nov;6(6):321-327. doi: 10.1159/000481253. Epub 2017 Oct 13. PubMed PMID: 29234626; PubMed Central PMCID: PMC5704697. 3: Buonfrate D, Paradies P, Iarussi F, Formenti F, Perandin F, Otranto D, Bisoffi Z. Serological and molecular tests for the diagnosis of Strongyloides stercoralis infection in dogs. Parasitol Res. 2017 Jul;116(7):2027-2029. doi: 10.1007/s00436-017-5468-0. Epub 2017 May 10. PubMed PMID: 28493000. 4: Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells. J Nutr Biochem. 2017 Apr;42:37-42. doi: 10.1016/j.jnutbio.2016.12.014. Epub 2017 Jan 9. PubMed PMID: 28113103. 5: Kovács L, Kézér FL, Ruff F, Szenci O. Rumination time and reticuloruminal temperature as possible predictors of dystocia in dairy cows. J Dairy Sci. 2017 Feb;100(2):1568-1579. doi: 10.3168/jds.2016-11884. Epub 2016 Dec 14. PubMed PMID: 27988119. 6: Buonfrate D, Angheben A, Gobbi F, Mistretta M, Degani M, Bisoffi Z. Four clusters of Trichostrongylus infection diagnosed in a single center, in Italy. Infection. 2017 Apr;45(2):233-236. doi: 10.1007/s15010-016-0957-0. Epub 2016 Oct 27. PubMed PMID: 27796847. 7: Aktan Ç, Özgür Ö, Sindel T, Dora B. Characteristics of headache during and after digital substraction angiography: A critical re-appraisal of the ICHD-3 criteria. Cephalalgia. 2017 Oct;37(11):1074-1081. doi: 10.1177/0333102416665878. Epub 2016 Aug 23. PubMed PMID: 27558501. 8: Kovács L, Kézér FL, Ruff F, Szenci O. Timing of obstetrical assistance affects peripartal cardiac autonomic function and early maternal behavior of dairy cows. Physiol Behav. 2016 Oct 15;165:202-10. doi: 10.1016/j.physbeh.2016.08.001. Epub 2016 Aug 2. PubMed PMID: 27494992. 9: Varthya M, Pawar H, Singh C, Dora CP, Jena SK, Suresh S. Development of Novel Polymer-Lipid Hybrid Nanoparticles of Tamoxifen: In Vitro and In Vivo Evaluation. J Nanosci Nanotechnol. 2016 Jan;16(1):253-60. PubMed PMID: 27398452. 10: Dora JM, Torres FS, Gerchman M, Fogliatto FS. Development of a local relative value unit to measure radiologists' computed tomography reporting workload. J Med Imaging Radiat Oncol. 2016 Dec;60(6):714-719. doi: 10.1111/1754-9485.12492. Epub 2016 Jul 11. PubMed PMID: 27397691. 11: Kovács L, Kézér FL, Szenci O. Effect of calving process on the outcomes of delivery and postpartum health of dairy cows with unassisted and assisted calvings. J Dairy Sci. 2016 Sep;99(9):7568-7573. doi: 10.3168/jds.2016-11325. Epub 2016 Jul 7. PubMed PMID: 27394943. 12: Dora CP, Trotta F, Kushwah V, Devasari N, Singh C, Suresh S, Jain S. Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability. Carbohydr Polym. 2016 Feb 10;137:339-349. doi: 10.1016/j.carbpol.2015.10.080. Epub 2015 Oct 28. PubMed PMID: 26686138. 13: Hädrich G, Monteiro SO, Rodrigues MR, de Lima VR, Putaux JL, Bidone J, Teixeira HF, Muccillo-Baisch AL, Dora CL. Lipid-based nanocarrier for quercetin delivery: system characterization and molecular interactions studies. Drug Dev Ind Pharm. 2016;42(7):1165-73. doi: 10.3109/03639045.2015.1118491. Epub 2015 Dec 7. PubMed PMID: 26571009. 14: Devasari N, Dora CP, Singh C, Paidi SR, Kumar V, Sobhia ME, Suresh S. Inclusion complex of erlotinib with sulfobutyl ether-β-cyclodextrin: Preparation, characterization, in silico, in vitro and in vivo evaluation. Carbohydr Polym. 2015 Dec 10;134:547-56. doi: 10.1016/j.carbpol.2015.08.012. Epub 2015 Aug 12. PubMed PMID: 26428157. 15: Piva S, Dora G, Minelli C, Michelini M, Turla F, Mazza S, D'Ottavi P, Moreno-Duarte I, Sottini C, Eikermann M, Latronico N. The Surgical Optimal Mobility Score predicts mortality and length of stay in an Italian population of medical, surgical, and neurologic intensive care unit patients. J Crit Care. 2015 Dec;30(6):1251-7. doi: 10.1016/j.jcrc.2015.08.002. Epub 2015 Aug 5. PubMed PMID: 26315654. 16: Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aβ generation. Mol Neurodegener. 2015 Jul 23;10:31. doi: 10.1186/s13024-015-0028-5. PubMed PMID: 26202512; PubMed Central PMCID: PMC4511450. 17: Beig MI, Horiuchi J, Dampney RA, Carrive P. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus. Clin Exp Pharmacol Physiol. 2015 Oct;42(10):1059-67. doi: 10.1111/1440-1681.12461. PubMed PMID: 26174505. 18: Karen A, Sousa NM, Beckers JF, Bajcsy ÁC, Tibold J, Mádl I, Szenci O. Comparison of a commercial bovine pregnancy-associated glycoprotein ELISA test and a pregnancy-associated glycoprotein radiomimmunoassay test for early pregnancy diagnosis in dairy cattle. Anim Reprod Sci. 2015 Aug;159:31-7. doi: 10.1016/j.anireprosci.2015.05.005. Epub 2015 May 29. PubMed PMID: 26059776. 19: Dietrich M, Zingg PO, Egbring M, Kamath AF, Dora C. Pre-hospital medications in total hip arthroplasty: risk factors for poor outcomes. Hip Int. 2015 May-Jun;25(3):215-20. doi: 10.5301/hipint.5000227. Epub 2015 Apr 15. PubMed PMID: 25907386. 20: Szelényi Z, Répási A, de Sousa NM, Beckers JF, Szenci O. Accuracy of diagnosing double corpora lutea and twin pregnancy by measuring serum progesterone and bovine pregnancy-associated glycoprotein 1 in the first trimester of gestation in dairy cows. Theriogenology. 2015 Jul 1;84(1):76-81. doi: 10.1016/j.theriogenology.2015.02.014. Epub 2015 Feb 25. PubMed PMID: 25864126.