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MedKoo Cat#: 597053 | Name: Ribulose, L-
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ribulose is an important metabolite in pentose interconversions. Ribulose is useful for analyzing L-ribose isomerase, engineering yeast for xylose metabolism, interesting chiral pool compound.

Chemical Structure

Ribulose, L-
Ribulose, L-
CAS#2042-27-5

Theoretical Analysis

MedKoo Cat#: 597053

Name: Ribulose, L-

CAS#: 2042-27-5

Chemical Formula: C5H10O5

Exact Mass: 150.0528

Molecular Weight: 150.13

Elemental Analysis: C, 40.00; H, 6.71; O, 53.28

Price and Availability

Size Price Availability Quantity
10mg USD 400.00 2 Weeks
50mg USD 750.00 2 Weeks
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Synonym
Ribulose, L-; L-Ribulose; L-Erythro-pentulose; L-Adonose; L-erythro-2-Pentulose.
IUPAC/Chemical Name
(3S,4S)-1,3,4,5-tetrahydroxypentan-2-one
InChi Key
ZAQJHHRNXZUBTE-UCORVYFPSA-N
InChi Code
InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5-/m0/s1
SMILES Code
OCC([C@H]([C@H](CO)O)O)=O
Appearance
Liquid
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
L-Ribulose is an isomer of L-ribose.
In vitro activity:
In view of its strong thermostability and high catalytic efficiency, L. endophytica l-Ribulose 3-epimerase might be a potential alternative for d-allulose industrial production of low-calorie rare sugars. Reference: Int J Biol Macromol. 2021 Oct 31;189:214-222. https://pubmed.ncbi.nlm.nih.gov/34428486/
In vivo activity:
Escherichia coli L-arabinose isomerase (ECAI; EC 5.3.1.4) catalyzes the isomerization of L-arabinose to L-ribulose in vivo. The crystal structure of ECAI forms a basis for identifying molecular determinants responsible for isomerization of arabinose to ribulose in vivo. Reference: J Mol Biol. 2006 Jul 7;360(2):297-309. https://pubmed.ncbi.nlm.nih.gov/16756997/

Preparing Stock Solutions

The following data is based on the product molecular weight 150.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Chen J, Wu H, Zhang W, Mu W. Recent advances in properties, production, and applications of L-ribulose. Appl Microbiol Biotechnol. 2020 Jul;104(13):5663-5672. doi: 10.1007/s00253-020-10637-5. Epub 2020 May 5. PMID: 32372201. 2. Chen D, Chen J, Liu X, Guang C, Zhang W, Mu W. Biochemical identification of a hyperthermostable l-ribulose 3-epimerase from Labedella endophytica and its application for d-allulose bioconversion. Int J Biol Macromol. 2021 Oct 31;189:214-222. doi: 10.1016/j.ijbiomac.2021.08.131. Epub 2021 Aug 21. PMID: 34428486. 3. Manjasetty BA, Chance MR. Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production. J Mol Biol. 2006 Jul 7;360(2):297-309. doi: 10.1016/j.jmb.2006.04.040. Epub 2006 May 5. PMID: 16756997.
In vitro protocol:
1. Chen J, Wu H, Zhang W, Mu W. Recent advances in properties, production, and applications of L-ribulose. Appl Microbiol Biotechnol. 2020 Jul;104(13):5663-5672. doi: 10.1007/s00253-020-10637-5. Epub 2020 May 5. PMID: 32372201. 2. Chen D, Chen J, Liu X, Guang C, Zhang W, Mu W. Biochemical identification of a hyperthermostable l-ribulose 3-epimerase from Labedella endophytica and its application for d-allulose bioconversion. Int J Biol Macromol. 2021 Oct 31;189:214-222. doi: 10.1016/j.ijbiomac.2021.08.131. Epub 2021 Aug 21. PMID: 34428486.
In vivo protocol:
1. Manjasetty BA, Chance MR. Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production. J Mol Biol. 2006 Jul 7;360(2):297-309. doi: 10.1016/j.jmb.2006.04.040. Epub 2006 May 5. PMID: 16756997.
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PubMed PMID: 29538315; PubMed Central PMCID: PMC5877713. 4: Fleming EJ, Woyke T, Donatello AR, Kuypers MMM, Sczyrba A, Littmann S, Emerson D. Insights into the fundamental physiology of the uncultured Fe-oxidizing bacterium Leptothrix ochracea. Appl Environ Microbiol. 2018 Feb 16. pii: AEM.02239-17. doi: 10.1128/AEM.02239-17. [Epub ahead of print] PubMed PMID: 29453262; PubMed Central PMCID: PMC5930342. 5: Yeo IS, Shim WY, Kim JH. Construction of genetically engineered Candida tropicalis for conversion of l-arabinose to l-ribulose. J Biotechnol. 2018 May 20;274:9-14. doi: 10.1016/j.jbiotec.2018.01.019. Epub 2018 Jan 31. PubMed PMID: 29407417. 6: Valegård K, Hasse D, Andersson I, Gunn LH. Structure of Rubisco from Arabidopsis thaliana in complex with 2-carboxyarabinitol-1,5-bisphosphate. Acta Crystallogr D Struct Biol. 2018 Jan 1;74(Pt 1):1-9. doi: 10.1107/S2059798317017132. Epub 2018 Jan 1. 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PubMed PMID: 29054811. 10: Agafonova NV, Kaparullina EN, Trotsenko YA, Doronina NV. Ancylobacter sonchi sp. nov., a novel methylotrophic bacterium frоm roots of Sonchus arvensis L. Int J Syst Evol Microbiol. 2017 Nov;67(11):4552-4558. doi: 10.1099/ijsem.0.002330. Epub 2017 Oct 6. PubMed PMID: 28984222. 11: Fusaro L, Palma A, Salvatori E, Basile A, Maresca V, Asadi Karam E, Manes F. Functional indicators of response mechanisms to nitrogen deposition, ozone, and their interaction in two Mediterranean tree species. PLoS One. 2017 Oct 3;12(10):e0185836. doi: 10.1371/journal.pone.0185836. eCollection 2017. PubMed PMID: 28973038; PubMed Central PMCID: PMC5626521. 12: Verma P, Khan SA, Masood N, Manika N, Sharma A, Verma N, Luqman S, Mathur AK. Differential rubisco content and photosynthetic efficiency of rol gene integrated Vinca minor transgenic plant: Correlating factors associated with morpho-anatomical changes, gene expression and alkaloid productivity. 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