Tripterifordin | CAS#139122-81-9 | anti-AIDS agent

MedKoo Cat#: 558156 | Name: Tripterifordin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tripterifordin is an anti-AIDS agent from Trypterygium wilfordii.

Chemical Structure

Tripterifordin

CAS#139122-81-9

Theoretical Analysis

MedKoo Cat#: 558156

Name: Tripterifordin

CAS#: 139122-81-9

Chemical Formula: C20H30O3

Exact Mass: 318.2200

Molecular Weight: 318.46

Elemental Analysis: C, 75.43; H, 9.50; O, 15.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

IUPAC/Chemical Name

(4S,4aS,6aS,8R,9S,11aR,11bR)-8-hydroxy-4,8-dimethyldodecahydro-1H-6a,9-methano-4,11b-(methanooxymethano)cyclohepta[a]naphthalen-14-one

InChi Key

KLMZPLYXGZZBCX-CXICKFFISA-N

InChi Code

InChI=1S/C20H30O3/c1-17-7-3-8-20(12-23-16(17)21)14(17)6-9-19-10-13(4-5-15(19)20)18(2,22)11-19/h13-15,22H,3-12H2,1-2H3/t13-,14+,15+,17-,18+,19-,20-/m0/s1

SMILES Code

(4S,4aS,6aS,8R,9S,11aR,11bR)-8-hydroxy-4,8-dimethyldodecahydro-1H-6a,9-methano-4,11b-(methanooxymethano)cyclohepta[a]naphthalen-14-one

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 318.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Luo H, Wu X, Huang H, Chen S, Yang W, Zhang L, Cui H, Yang J, Yang A. Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid chromatography-triple quadrupole mass spectrometry. J Pharm Biomed Anal. 2016 Jan 5;117:195-204. doi: 10.1016/j.jpba.2015.08.043. Epub 2015 Sep 3. PubMed PMID: 26363489. 2: Chen K, Shi QA, Fujioka T, Zhang DC, Hu CQ, Jin JQ, Kilkuskie RE, Lee KH. Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation. J Nat Prod. 1992 Jan;55(1):88-92. PubMed PMID: 1602302. 3: Duan H, Takaishi Y, Momota H, Ohmoto Y, Taki T, Jia Y, Li D. Immunosuppressive diterpenoids from Tripterygium wilfordii. J Nat Prod. 1999 Nov;62(11):1522-5. PubMed PMID: 10579865. 4: Kobayashi S, Shibukawa K, Hamada Y, Kuruma T, Kawabata A, Masuyama A. Syntheses of (-)-Tripterifordin and (-)-Neotripterifordin from Stevioside. J Org Chem. 2018 Feb 2;83(3):1606-1613. doi: 10.1021/acs.joc.7b02916. Epub 2018 Jan 12. PubMed PMID: 29328659. 5: Zhang L, Zhang ZX, Sheng LS, An DK, Lu Y, Zheng QT, Wang SC. [Study on the chemical constituents of Tripterygium hypoglaucum (Lévl.) Hutch]. Yao Xue Xue Bao. 1993;28(1):32-4. Chinese. PubMed PMID: 8328267. 6: Su P, Guan H, Zhang Y, Wang X, Gao L, Zhao Y, Hu T, Zhou J, Ma B, Tu L, Tong Y, Huang L, Gao W. Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent-Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii. Front Plant Sci. 2017 Oct 13;8:1756. doi: 10.3389/fpls.2017.01756. eCollection 2017. PubMed PMID: 29081786; PubMed Central PMCID: PMC5645531.