MedKoo Cat#: 563033 | Name: L524-0366

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L524-0366 is an inhibitor of the TWEAK-Fn14 signaling cascade.

Chemical Structure

L524-0366
L524-0366
CAS#951612-19-4

Theoretical Analysis

MedKoo Cat#: 563033

Name: L524-0366

CAS#: 951612-19-4

Chemical Formula: C13H13ClN4OS

Exact Mass: 308.0499

Molecular Weight: 308.78

Elemental Analysis: C, 50.57; H, 4.24; Cl, 11.48; N, 18.14; O, 5.18; S, 10.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L524-0366; L524 0366; L5240366;
IUPAC/Chemical Name
[1-(3-Chloro-phenyl)-1H-[1,2,3]triazol-4-yl]-thiomorpholin-4-yl-methanone
InChi Key
ZOBDTKWDYMRKPF-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H13ClN4OS/c14-10-2-1-3-11(8-10)18-9-12(15-16-18)13(19)17-4-6-20-7-5-17/h1-3,8-9H,4-7H2
SMILES Code
O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xia Y, Campbell SR, Broder A, Herlitz L, Abadi M, Wu P, Michaelson JS, Burkly LC, Putterman C. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol. 2012 Nov;145(2):108-21. doi: 10.1016/j.clim.2012.08.008. Epub 2012 Aug 20. PubMed PMID: 22982296; PubMed Central PMCID: PMC3483377.