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MedKoo Cat#: 563032 | Name: CFM-4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CFM-4 is a CARP-1 mimetic. It acts by enhancing CARP-1 expression and inducing G2/M cell cycle arrest.

Chemical Structure

CFM-4
CFM-4
CAS#331458-02-7

Theoretical Analysis

MedKoo Cat#: 563032

Name: CFM-4

CAS#: 331458-02-7

Chemical Formula: C22H16ClN3OS

Exact Mass: 405.0703

Molecular Weight: 405.90

Elemental Analysis: C, 65.10; H, 3.97; Cl, 8.73; N, 10.35; O, 3.94; S, 7.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CFM-4; CFM 4; CFM4;
IUPAC/Chemical Name
1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
InChi Key
PMADITKBVODKSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H16ClN3OS/c23-18-12-6-4-10-16(18)14-26-19-13-7-5-11-17(19)22(21(26)27)25-24-20(28-22)15-8-2-1-3-9-15/h1-13,25H,14H2
SMILES Code
O=C1N(CC2=CC=CC=C2Cl)C3=C(C=CC=C3)C14SC(C5=CC=CC=C5)=NN4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cheriyan VT, Alsaab HO, Sekhar S, Stieber C, Kesharwani P, Sau S, Muthu M, Polin LA, Levi E, Iyer AK, Rishi AK. A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma. Oncotarget. 2017 Sep 5;8(62):104928-104945. doi: 10.18632/oncotarget.20650. eCollection 2017 Dec 1. PubMed PMID: 29285223; PubMed Central PMCID: PMC5739610. 2: Cheriyan VT, Muthu M, Patel K, Sekhar S, Rajeswaran W, Larsen SD, Polin L, Levi E, Singh M, Rishi AK. CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers. Oncotarget. 2016 Nov 8;7(45):73370-73388. doi: 10.18632/oncotarget.12333. PubMed PMID: 27687593; PubMed Central PMCID: PMC5341985. 3: Muthu M, Somagoni J, Cheriyan VT, Munie S, Levi E, Ashour AE, Yassin AE, Alafeefy AM, Sochacki P, Polin LA, Reddy KB, Larsen SD, Singh M, Rishi AK. Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers. J Biomed Nanotechnol. 2015 Sep;11(9):1608-27. PubMed PMID: 26485930; PubMed Central PMCID: PMC5090172. 4: Chukkapalli S, Levi E, Rishi AK, Datta NS. PTHrP attenuates osteoblast cell death and apoptosis induced by a novel class of anti-cancer agents. Endocrine. 2016 Mar;51(3):534-44. doi: 10.1007/s12020-015-0699-2. Epub 2015 Aug 11. PubMed PMID: 26260694. 5: Muthu M, Cheriyan VT, Rishi AK. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6(9):6499-510. Review. PubMed PMID: 25894788; PubMed Central PMCID: PMC4466629. 6: Muthu M, Cheriyan VT, Munie S, Levi E, Frank J, Ashour AE, Singh M, Rishi AK. Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics. PLoS One. 2014 Jul 17;9(7):e102567. doi: 10.1371/journal.pone.0102567. eCollection 2014. PubMed PMID: 25033461; PubMed Central PMCID: PMC4102511. 7: Jamal S, Cheriyan VT, Muthu M, Munie S, Levi E, Ashour AE, Pass HI, Wali A, Singh M, Rishi AK. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. PLoS One. 2014 Mar 5;9(3):e89146. doi: 10.1371/journal.pone.0089146. eCollection 2014. PubMed PMID: 24598827; PubMed Central PMCID: PMC3943785. 8: Ashour AE, Jamal S, Cheryan VT, Muthu M, Zoheir KM, Alafeefy AM, Abd-Allah AR, Levi E, Tarca AL, Polin LA, Rishi AK. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8(6):e66733. doi: 10.1371/journal.pone.0066733. Print 2013. PubMed PMID: 23826121; PubMed Central PMCID: PMC3691183. 9: Puliyappadamba VT, Wu W, Bevis D, Zhang L, Polin L, Kilkuskie R, Finley RL Jr, Larsen SD, Levi E, Miller FR, Wali A, Rishi AK. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-17. doi: 10.1074/jbc.M111.222398. Epub 2011 Sep 8. PubMed PMID: 21903591; PubMed Central PMCID: PMC3207393. 10: Rizzo M, De Sarro G, Zappalà M, Chimirri A. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):207-15. PubMed PMID: 10510773. 11: De Sarro G, Rizzo M, Spagnolo C, Gitto R, De Sarro A, Scotto G, Zappala M, Chimirri A. Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol Biochem Behav. 1999 Aug;63(4):621-7. PubMed PMID: 10462191.

View History

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CFLZ-567