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MedKoo Cat#: 597008 | Name: Fibrostatin C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fibrostatin C is a prolyl 4-hydroxylase (PH) inhibitor produced by Streptomyces catenulae subsp. griseospora.

Chemical Structure

Fibrostatin C
Fibrostatin C
CAS#91776-47-5

Theoretical Analysis

MedKoo Cat#: 597008

Name: Fibrostatin C

CAS#: 91776-47-5

Chemical Formula: C18H19NO8S

Exact Mass: 409.0831

Molecular Weight: 409.40

Elemental Analysis: C, 52.81; H, 4.68; N, 3.42; O, 31.26; S, 7.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Fibrostatin C;
IUPAC/Chemical Name
N-acetyl-S-((1-hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl)-L-cysteine
InChi Key
PBMJDDQAEYEYKK-NSHDSACASA-N
InChi Code
InChI=1S/C18H19NO8S/c1-8(20)19-11(18(24)25)7-28-6-10-13(26-2)4-9-15(17(10)23)12(21)5-14(27-3)16(9)22/h4-5,11,23H,6-7H2,1-3H3,(H,19,20)(H,24,25)/t11-/m0/s1
SMILES Code
O=C(O)[C@H](CSCC(C(O)=C1C2=O)=C(OC)C=C1C(C(OC)=C2)=O)NC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saika S, Ooshima A, Yamanaka O, Okada Y, Tanaka S, Ohnishi Y. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. PubMed PMID: 8871177. 2: Kawaguchi Y, Harigai M, Kitani A, Suzuki K, Kawakami M, Ishizuka T, Hidaka T, Hara M, Kawagoe M, Nakamura H. Effect of prolyl 4-hydroxylase inhibitor on fibroblast collagen production in vitro: an approach to the treatment of systemic sclerosis. J Rheumatol. 1992 Nov;19(11):1710-5. PubMed PMID: 1337110. 3: Ishimaru T, Kanamaru T, Takahashi T, Okazaki H. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. PubMed PMID: 2848793. 4: Ohta K, Kasahara F, Ishimaru T, Wada Y, Kanamaru T, Okazaki H. Structures of fibrostatins, new inhibitors of prolyl hydroxylase. J Antibiot (Tokyo). 1987 Sep;40(9):1239-48. PubMed PMID: 2824420. 5: Ishimaru T, Kanamaru T, Ohta K, Okazaki H. Fibrostatins, new inhibitors of prolyl hydroxylase. I. Taxonomy, isolation and characterization. J Antibiot (Tokyo). 1987 Sep;40(9):1231-8. PubMed PMID: 2824419.