K-8012 | CAS#1346513-17-4 | RXR inhibitor

MedKoo Cat#: 558217 | Name: K-8012

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K-8012 is an inhibitor of the interaction of the N-terminally truncated RXR.

Chemical Structure

K-8012

CAS#1346513-17-4

Theoretical Analysis

MedKoo Cat#: 558217

Name: K-8012

CAS#: 1346513-17-4

Chemical Formula: C23H23FN4

Exact Mass: 374.1907

Molecular Weight: 374.46

Elemental Analysis: C, 73.77; H, 6.19; F, 5.07; N, 14.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

K-8012; K 8012; K8012;

IUPAC/Chemical Name

(Z)-5-(2-(5-Fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)ethyl)-1Htetrazole

InChi Key

XBRDZHUUARVXDN-MTJSOVHGSA-N

InChi Code

InChI=1S/C23H23FN4/c1-14(2)17-6-4-16(5-7-17)12-21-15(3)19(10-11-23-25-27-28-26-23)22-13-18(24)8-9-20(21)22/h4-9,12-14H,10-11H2,1-3H3,(H,25,26,27,28)/b21-12-

SMILES Code

CC(/C1=C/C2=CC=C(C(C)C)C=C2)=C(CCC3=NN=NN3)C4=C1C=CC(F)=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y. Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site. Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3. PubMed PMID: 24704507; PubMed Central PMCID: PMC4035439.