Synonym
Cysteine isopropyl ester; Cysteine isopropylester; CIPE;
IUPAC/Chemical Name
isopropyl L-cysteinate
InChi Key
HXHFZINLHDNRTP-YFKPBYRVSA-N
InChi Code
InChI=1S/C6H13NO2S/c1-4(2)9-6(8)5(7)3-10/h4-5,10H,3,7H2,1-2H3/t5-/m0/s1
SMILES Code
N[C@@H](CS)C(OC(C)C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
163.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Langenberg JP, van der Schans GP, Spruit HE, Kuijpers WC, Mars-Groenendijk RH, van Dijk-Knijnenburg HC, Trap HC, van Helden HP, Benschop HP. Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig. Drug Chem Toxicol. 1998;21 Suppl 1:131-47. PubMed PMID: 10028407.
2: Hobbs MJ, Williams NE, Patel SK, Upshall DG. Elevation of endogenous nucleophiles in rat lung by cysteine and glutathione esters in vitro. Biochem Pharmacol. 1998 May 15;55(10):1573-84. PubMed PMID: 9633993.
3: Langford AM, Hobbs MJ, Upshall DG, Blain PG, Williams FM. The effect of sulphur mustard on glutathione levels in rat lung slices and the influence of treatment with arylthiols and cysteine esters. Hum Exp Toxicol. 1996 Aug;15(8):619-24. PubMed PMID: 8863055.
4: Butterworth M, Upshall DG, Cohen GM. A novel role for carboxylesterase in the elevation of cellular cysteine by esters of cysteine. Biochem Pharmacol. 1993 Oct 5;46(7):1131-7. PubMed PMID: 8216362.
5: Butterworth M, Upshall DG, Hobbs M, Cohen GM. Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors. Biochem Pharmacol. 1993 May 5;45(9):1769-74. PubMed PMID: 8494535.
6: Hobbs MJ, Butterworth M, Cohen GM, Upshall DG. Structure-activity relationships of cysteine esters and their effects on thiol levels in rat lung in vitro. Biochem Pharmacol. 1993 Apr 22;45(8):1605-12. PubMed PMID: 8484801.
7: Butterworth M, Upshall DG, Smith LL, Cohen GM. Cysteine isopropylester protects against paracetamol-induced toxicity. Biochem Pharmacol. 1992 Feb 4;43(3):483-8. PubMed PMID: 1540206.
8: Lailey AF, Hill L, Lawston IW, Stanton D, Upshall DG. Protection by cysteine esters against chemically induced pulmonary oedema. Biochem Pharmacol. 1991 Dec 11;42 Suppl:S47-54. PubMed PMID: 1768285.
