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MedKoo Cat#: 596976 | Name: TP 9201

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TP 9201 is a platelet integrin alphaIIbbeta3 (GPIIb/IIIa) antagonist; a synthetic RGD-containing cyclic peptide; may be effective in prevention of re-thrombosis after thromolytic therapy without adversely affecting hemostasis.

Chemical Structure

TP 9201
TP 9201
CAS#138297-15-1

Theoretical Analysis

MedKoo Cat#: 596976

Name: TP 9201

CAS#: 138297-15-1

Chemical Formula: C45H69N17O14S2

Exact Mass: 1135.4651

Molecular Weight: 1136.27

Elemental Analysis: C, 47.57; H, 6.12; N, 20.96; O, 19.71; S, 5.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TP 9201; TP-9201; TP9201;
IUPAC/Chemical Name
2-((3R,9R,12S,15R,18S,23R,26R,31aR)-23-acetamido-26-(2-amino-2-oxoethyl)-18-carbamoyl-3,15-bis(3-guanidinopropyl)-12-(4-methoxybenzyl)-1,4,7,10,13,16,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-v][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosin-9-yl)acetic acid
InChi Key
RRPUNOOJZOAZNU-GDMCLWAISA-N
InChi Code
InChI=1S/C45H69N17O14S2/c1-22(63)55-31-21-78-77-20-30(36(47)68)61-38(70)26(7-4-14-53-45(50)51)57-39(71)27(16-23-9-11-24(76-2)12-10-23)59-40(72)28(18-35(66)67)56-34(65)19-54-37(69)25(6-3-13-52-44(48)49)58-42(74)32-8-5-15-62(32)43(75)29(17-33(46)64)60-41(31)73/h9-12,25-32H,3-8,13-21H2,1-2H3,(H2,46,64)(H2,47,68)(H,54,69)(H,55,63)(H,56,65)(H,57,71)(H,58,74)(H,59,72)(H,60,73)(H,61,70)(H,66,67)(H4,48,49,52)(H4,50,51,53)/t25-,26-,27+,28-,29-,30-,31+,32-/m1/s1
SMILES Code
O=C(N)C[C@@H]1C(N2CCC[C@@H]2C(N[C@H](CCCNC(N)=N)C(NCC(N[C@H](CC(O)=O)C(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@H](CSSC[C@H](NC(C)=O)C(N1)=O)C(N)=O)=O)=O)Cc3ccc(OC)cc3)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,136.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF, Pierschbacher MD, del Zoppo GJ. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke. 2000 Jun;31(6):1402-09; discussion 1409-10. PubMed PMID: 10835463. 2: TP 9201. Drugs R D. 1999 May;1(5):390-1. PubMed PMID: 10566073. 3: Rebello SS, Driscoll EM, Lucchesi BR. TP-9201, a glycoprotein IIb/IIIa platelet receptor antagonist, prevents rethrombosis after successful arterial thrombolysis in the dog. Stroke. 1997 Sep;28(9):1789-96. PubMed PMID: 9303027. 4: Modi NB, Reynolds T, Baughman SA, Thomas DA, Paasch BD, Smith SY. Pharmacokinetics and pharmacodynamics of TP-9201, a gpIIbIIIa antagonist, administered in combination with recombinant tissue-type plasminogen activator, heparin, and aspirin in beagles. J Cardiovasc Pharmacol. 1996 Jan;27(1):105-12. PubMed PMID: 8656642. 5: Woltman SJ, Chen JG, Weber SG, Tolley JO. Determination of the pharmaceutical peptide TP9201 by post-column reaction with copper(II) followed by electrochemical detection. J Pharm Biomed Anal. 1995 Dec;14(1-2):155-64. PubMed PMID: 8833978. 6: Modi NB, Baughman SA, Paasch BD, Celniker A, Smith SY. Pharmacokinetics and pharmacodynamics of TP-9201, a GPIIbIIIa antagonist, in rats and dogs. J Cardiovasc Pharmacol. 1995 Jun;25(6):888-97. PubMed PMID: 7564333. 7: Mazur C, Tschopp JF, Faliakou EC, Gould KE, Diehl JT, Pierschbacher MD, Connolly RJ. Selective alpha IIb beta 3 receptor blockage with peptide TP9201 prevents platelet uptake on Dacron vascular grafts without significant effect on bleeding time. J Lab Clin Med. 1994 Oct;124(4):589-99. PubMed PMID: 7523555. 8: Collen D, Lu HR, Stassen JM, Vreys I, Yasuda T, Bunting S, Gold HK. Antithrombotic effects and bleeding time prolongation with synthetic platelet GPIIb/IIIa inhibitors in animal models of platelet-mediated thrombosis. Thromb Haemost. 1994 Jan;71(1):95-102. PubMed PMID: 8165652. 9: Tschopp JF, Craig WS, Tolley J, Blevitt J, Mazur C, Pierschbacher MD. Therapeutic application of matrix biology. Methods Enzymol. 1994;245:556-69. PubMed PMID: 7760751. 10: Tschopp JF, Driscoll EM, Mu DX, Black SC, Pierschbacher MD, Lucchesi BR. Inhibition of coronary artery reocclusion after thrombolysis with an RGD-containing peptide with no significant effect on bleeding time. Coron Artery Dis. 1993 Sep;4(9):809-17. PubMed PMID: 8287215. a

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