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MedKoo Cat#: 558132 | Name: Potassium gluconate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Potassium gluconate is a mineral supplement used to treat or prevent low amounts of potassium in the blood. Potassium gluconate was used to replace the more harmful reactants that are conventionally used in Cu(2)O production.

Chemical Structure

Potassium gluconate
Potassium gluconate
CAS#299-27-4

Theoretical Analysis

MedKoo Cat#: 558132

Name: Potassium gluconate

CAS#: 299-27-4

Chemical Formula: C6H11KO7

Exact Mass: 234.0142

Molecular Weight: 234.25

Elemental Analysis: C, 30.77; H, 4.73; K, 16.69; O, 47.81

Price and Availability

Size Price Availability Quantity
100g USD 400.00 2 Weeks
500g USD 625.00 2 Weeks
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Related CAS #
No Data
Synonym
HSDB 3165; K-Iao; Kalium Gluconate; Kalium-beta; Kaon; Kaon elixir;
IUPAC/Chemical Name
D-Gluconic acid, monopotassium salt
InChi Key
HLCFGWHYROZGBI-JJKGCWMISA-M
InChi Code
InChI=1S/C6H12O7.K/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C([O-])=O.[K+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Potassium Gluconate (Potassium D-gluconate) is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties.
In vitro activity:
Cultures were treated with either potassium gluconate or the sodium-potassium pump blocker ouabain and evaluated for proliferation, DNA content using propidum iodide staining, and differentiation. Cell proliferation measurements showed a modest stimulatory effect at certain concentration ranges for each agent, but higher concentrations of potassium gluconate strongly inhibited growth in a dose dependent manner. Cell cycle analysis with flow cytometry demonstrated an increase in the number of cells in S phase, but increasing concentrations of potassium gluconate arrested cells at G1. Immunostaining, Western blot analysis and light microscopy revealed that potassium gluconate exposure delayed cell fusion and maintained a higher population of cells expressing the muscle stem cell marker Pax7. Reference: Stem Cell Rev Rep. 2016 Dec;12(6):634-644. https://pubmed.ncbi.nlm.nih.gov/27696329/
In vivo activity:
Increasing concentrations of KGluc (potassium gluconate) also inhibited differentiation into myofibroblasts, suggesting that local KGluc treatment might reduce fibrosis. KGluc delivery was confirmed via loading into collagen hydrogels and used to treat a full thickness skin wound in mice. KGluc qualitatively slowed initial closure of the wounds and resulted in tissue that more closely resembled mature, healthy skin (epidermal thickness and dermal-epidermal morphology) when compared to unloaded collagen hydrogels. KGluc treatment significantly reduced the number of myofibroblasts within the dermis while upregulated blood vessel density with respect to unloaded hydrogels, likely a result of disruption of TGFβ1 signaling. Reference: ACS Biomater Sci Eng. 2019 Oct 14;5(10):5327-5336. https://pubmed.ncbi.nlm.nih.gov/32440531/
Solvent mg/mL mM comments
Solubility
DMSO 1.3 5.34
Water 100.0 426.90
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 234.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Fennelly C, Wang Z, Criswell T, Soker S. Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Properties In Vitro. Stem Cell Rev Rep. 2016 Dec;12(6):634-644. doi: 10.1007/s12015-016-9687-z. PMID: 27696329. 2. De Marchi U, Checchetto V, Zanetti M, Teardo E, Soccio M, Formentin E, Giacometti GM, Pastore D, Zoratti M, Szabò I. ATP-sensitive cation-channel in wheat (Triticum durum Desf.): identification and characterization of a plant mitochondrial channel by patch-clamp. Cell Physiol Biochem. 2010;26(6):975-82. doi: 10.1159/000324010. Epub 2011 Jan 4. PMID: 21220928. 3. Grasman JM, Williams MD, Razis CG, Bonzanni M, Golding AS, Cairns DM, Levin M, Kaplan DL. Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation. ACS Biomater Sci Eng. 2019 Oct 14;5(10):5327-5336. doi: 10.1021/acsbiomaterials.9b00810. Epub 2019 Sep 18. PMID: 32440531; PMCID: PMC7241611.
In vitro protocol:
1. Fennelly C, Wang Z, Criswell T, Soker S. Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Properties In Vitro. Stem Cell Rev Rep. 2016 Dec;12(6):634-644. doi: 10.1007/s12015-016-9687-z. PMID: 27696329. 2. De Marchi U, Checchetto V, Zanetti M, Teardo E, Soccio M, Formentin E, Giacometti GM, Pastore D, Zoratti M, Szabò I. ATP-sensitive cation-channel in wheat (Triticum durum Desf.): identification and characterization of a plant mitochondrial channel by patch-clamp. Cell Physiol Biochem. 2010;26(6):975-82. doi: 10.1159/000324010. Epub 2011 Jan 4. PMID: 21220928.
In vivo protocol:
1. Grasman JM, Williams MD, Razis CG, Bonzanni M, Golding AS, Cairns DM, Levin M, Kaplan DL. Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation. ACS Biomater Sci Eng. 2019 Oct 14;5(10):5327-5336. doi: 10.1021/acsbiomaterials.9b00810. Epub 2019 Sep 18. PMID: 32440531; PMCID: PMC7241611.
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Anoxybacillus karvacharensis sp. nov., a novel thermophilic bacterium isolated from the Karvachar geothermal spring in Nagorno-Karabakh. Int J Syst Evol Microbiol. 2021 Oct;71(10):005035. doi: 10.1099/ijsem.0.005035. PMID: 34596507; PMCID: PMC8604165. 4: Gutierrez-Albanchez E, García-Villaraco A, Lucas JA, Horche I, Ramos-Solano B, Gutierrez-Mañero FJ. Pseudomonas palmensis sp. nov., a Novel Bacterium Isolated From Nicotiana glauca Microbiome: Draft Genome Analysis and Biological Potential for Agriculture. Front Microbiol. 2021 Aug 20;12:672751. doi: 10.3389/fmicb.2021.672751. PMID: 34489881; PMCID: PMC8417607. 5: Stone MS, Martin BR, Weaver CM. Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults. Nutrients. 2021 May 11;13(5):1610. doi: 10.3390/nu13051610. PMID: 34064968; PMCID: PMC8151047. 6: Shimizu Y, Taga M, Takahashi Y, Tada I, Takase F, Niwa O, Masauji T. Study of the More Suitable Drugs and Dosage Forms for Administration to Newborn Infants via Feeding Tube Using the Collection Rate as an Indicator. Chem Pharm Bull (Tokyo). 2020;68(8):802-805. doi: 10.1248/cpb.c20-00154. PMID: 32741923. 7: Gao Y, He Y, Ivanov I, Yang X, Tian H, Liu X. Expression and functional study of VpV262 Pol, a moderately halophilic DNA polymerase from the Vibrio parahaemolyticus phage VpV262. Enzyme Microb Technol. 2020 Sep;139:109588. doi: 10.1016/j.enzmictec.2020.109588. Epub 2020 Jun 5. PMID: 32732037. 8: Grasman JM, Williams MD, Razis CG, Bonzanni M, Golding AS, Cairns DM, Levin M, Kaplan DL. Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation. ACS Biomater Sci Eng. 2019 Oct 14;5(10):5327-5336. doi: 10.1021/acsbiomaterials.9b00810. Epub 2019 Sep 18. PMID: 32440531; PMCID: PMC7241611. 9: Erndt-Marino J, Yeisley DJ, Chen H, Levin M, Kaplan DL, Hahn MS. Interferon- Gamma Stimulated Murine Macrophages In Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications. Bioelectricity. 2020 Mar 1;2(1):48-58. doi: 10.1089/bioe.2019.0032. Epub 2020 Mar 18. PMID: 32292895; PMCID: PMC7107958. 10: Gómez de la F CL, Novoa P JM, Caviedes R N. Bartter syndrome: An infrequent tubulopathy of prenatal onset. Rev Chil Pediatr. 2019 Aug;90(4):437-442. English, Spanish. doi: 10.32641/rchped.v90i4.932. PMID: 31859717. 11: McWilliams S, Flynn CD, McWilliams J, Arnold DC, Wahyuono RA, Undisz A, Rettenmayr M, Ignaszak A. Nanostructured Cu2O Synthesized via Bipolar Electrochemistry. Nanomaterials (Basel). 2019 Dec 15;9(12):1781. doi: 10.3390/nano9121781. PMID: 31847448; PMCID: PMC6956072. 12: Wang C, Wu W, Wei L, Feng Y, Kang M, Xie Y, Zong Z. Enterobacter wuhouensis sp. nov. and Enterobacter quasihormaechei sp. nov. recovered from human sputum. Int J Syst Evol Microbiol. 2020 Feb;70(2):874-881. doi: 10.1099/ijsem.0.003837. PMID: 31702537. 13: Sieberg LG, Quimby JM. Retrospective study of the efficacy of oral potassium supplementation in cats with kidney disease. J Feline Med Surg. 2020 Jun;22(6):539-543. doi: 10.1177/1098612X19862084. Epub 2019 Jul 15. PMID: 31304869; PMCID: PMC10814345. 14: Wu W, Wei L, Feng Y, Kang M, Zong Z. Enterobacter huaxiensis sp. nov. and Enterobacter chuandaensis sp. nov., recovered from human blood. Int J Syst Evol Microbiol. 2019 Mar;69(3):708-714. doi: 10.1099/ijsem.0.003207. PMID: 30614784. 15: Dai X, Shi K, Wang X, Fan J, Wang R, Zheng S, Wang G. Paenibacillus flagellatus sp. nov., isolated from selenium mineral soil. Int J Syst Evol Microbiol. 2019 Jan;69(1):183-188. doi: 10.1099/ijsem.0.003125. Epub 2018 Nov 21. PMID: 30461376. 16: Keller AS, Diederich L, Panknin C, DeLalio LJ, Drake JC, Sherman R, Jackson EK, Yan Z, Kelm M, Cortese-Krott MM, Isakson BE. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C593-C603. doi: 10.1152/ajpcell.00178.2017. Epub 2017 Aug 30. PMID: 28855161; PMCID: PMC5814586. 17: Bailey SJ, Blackwell JR, Wylie LJ, Emery A, Taylor E, Winyard PG, Jones AM. Influence of iodide ingestion on nitrate metabolism and blood pressure following short-term dietary nitrate supplementation in healthy normotensive adults. Nitric Oxide. 2017 Feb 28;63:13-20. doi: 10.1016/j.niox.2016.12.008. Epub 2016 Dec 23. PMID: 28024935. 18: Fennelly C, Wang Z, Criswell T, Soker S. Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Properties In Vitro. Stem Cell Rev Rep. 2016 Dec;12(6):634-644. doi: 10.1007/s12015-016-9687-z. PMID: 27696329. 19: Macdonald-Clarke CJ, Martin BR, McCabe LD, McCabe GP, Lachcik PJ, Wastney M, Weaver CM. Bioavailability of potassium from potatoes and potassium gluconate: a randomized dose response trial. Am J Clin Nutr. 2016 Aug;104(2):346-53. doi: 10.3945/ajcn.115.127225. Epub 2016 Jul 13. PMID: 27413123. 20: Rezzonico F, Smits THM, Born Y, Blom J, Frey JE, Goesmann A, Cleenwerck I, de Vos P, Bonaterra A, Duffy B, Montesinos E. Erwinia gerundensis sp. nov., a cosmopolitan epiphyte originally isolated from pome fruit trees. Int J Syst Evol Microbiol. 2016 Mar;66(3):1583-1592. doi: 10.1099/ijsem.0.000920. Epub 2016 Jan 26. PMID: 26813696.